Results 41 to 50 of about 858,835 (303)

Structural Transition and Antibody Binding of EBOV GP and ZIKV E Proteins from Pre-Fusion to Fusion-Initiation State

Biomolecules, 2018
Membrane fusion proteins are responsible for viral entry into host cells—a crucial first step in viral infection. These proteins undergo large conformational changes from pre-fusion to fusion-initiation structures, and, despite differences in viral
Anna Lappala, Wataru Nishima, Jacob Miner, Paul Fenimore, Will Fischer, Peter Hraber, Ming Zhang, Benjamin McMahon, Chang-Shung Tung   +8 more
doaj   +1 more source

Characterisation of a rare, reassortant human G10P[14] rotavirus strain detected in Honduras

Memorias do Instituto Oswaldo Cruz
BACKGROUND Although first detected in animals, the rare rotavirus strain G10P[14] has been sporadically detected in humans in Slovenia, Thailand, United Kingdom and Australia among other countries. Earlier studies suggest that the strains found in humans
Osbourne Quaye, Sunando Roy, Kunchala Rungsrisuriyachai, Mathew D Esona, Ziqian Xu, Ka Ian Tam, Dina J Castro Banegas, Gloria Rey-Benito, Michael D Bowen   +8 more
doaj   +1 more source

Glycosylation of viral proteins: Implication in virus–host interaction and virulence

Virulence, 2022
Glycans are among the most important cell molecular components. However, given their structural diversity, their functions have not been fully explored. Glycosylation is a vital post-translational modification for various proteins.
Tingting Feng, Jinyu Zhang, Zhiqiang Chen, Wen Pan, Zhengrong Chen, Yongdong Yan, Jianfeng Dai   +6 more
semanticscholar   +1 more source

HIV-1 Structural Proteins or Cell-Signaling Factors? That Is the Question!

Current Issues in Molecular Biology
The biological activity of structural HIV-1 proteins is not limited to ensuring a productive viral infection but also interferes with cellular homeostasis through intra- and extracellular signaling activation.
Michele Pellegrino, Francesca Giordano, Francesca De Amicis, Maria Marra, Paola Tucci, Stefania Marsico, Stefano Aquaro   +6 more
doaj   +1 more source

Spatiotemporal Coupling of the Hepatitis C Virus Replication Cycle by Creating a Lipid Droplet- Proximal Membranous Replication Compartment

Cell Reports, 2019
Summary: The hepatitis C virus (HCV) is a major cause of chronic liver disease, affecting around 71 million people worldwide. Viral RNA replication occurs in a membranous compartment composed of double-membrane vesicles (DMVs), whereas virus particles ...
Ji-Young Lee, Mirko Cortese, Uta Haselmann, Keisuke Tabata, Inés Romero-Brey, Charlotta Funaya, Nicole L. Schieber, Yu Qiang, Marie Bartenschlager, Stephanie Kallis, Christian Ritter, Karl Rohr, Yannick Schwab, Alessia Ruggieri, Ralf Bartenschlager   +14 more
doaj   +1 more source

Integrated analysis to study the interplay between post-translational modifications (PTM) in hepatitis C virus proteins and hepatocellular carcinoma (HCC) development

Scientific Reports, 2022
Many PTMs dysregulation is known to be the major cause of many cancers including HCV induced HCC. PTMs of hepatitis C virus (HCV) regions NS3/4A, NS5A and NS5B are crucial for proper protein functions and replication that directly affect the generation ...
Aqsa Ikram, Bisma Rauff, Badr Alzahrani, Faryal Mehwish Awan, Ayesha Obaid, Anam Naz, Salik Javed Kakar, Hussnain Ahmed Janjua   +7 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Towards a Universal Translator: Decoding the PTMs That Regulate Orthoflavivirus Infection

Viruses
Post-translational modifications (PTMs) serve as critical regulators of protein function across biological systems, including during viral infection. For orthoflaviviruses, including human pathogens like dengue, Zika, and West Nile viruses, PTMs on viral
Hannah M. Schmidt, Stacy M. Horner
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

A novel defective recombinant porcine enterovirus G virus carrying a porcine torovirus papain-like cysteine protease gene and a putative anti-apoptosis gene in place of viral structural protein genes

bioRxiv, 2019
Enterovirus G (EV-G) belongs to the family of Picornaviridae. Two types of recombinant porcine EV-Gs carrying papain-like cysteine protease (PLCP) gene of porcine torovirus, a virus in Coronaviridae, are reported. Type 1 recombinant EV-Gs are detected in
Ryo Imai, M. Nagai, M. Oba, Shoichi Sakaguchi, M. Ujike, Ruka Kimura, Moeko Kida, Tsuneyuki Masuda, Moegi Kuroda, Rongduo Wen, Kaixin Li, Y. Katayama, Y. Naoi, S. Tsuchiaka, T. Omatsu, Hiroshi Yamazato, S. Makino, T. Mizutani   +17 more
semanticscholar   +1 more source