Results 41 to 50 of about 246,650 (312)

The structure of viral coat protein and its role in disease

Trends in Microbiology, 1993
Because the structure of the tobacco mosaic virus capsid protein is known, mutations that alter the phenotype of the virus-plant interaction can be correlated with structural changes in this protein. These mutations affect the disease symptoms caused by the virus and recognition of the virus by a plant resistance gene product.
S. Chapman, A.G.C. Lindbeck and W.O. Dawson are in the University of Florida, Citrus Research and Education Center Experiment Station Road, Lake Alfred, FL 33850, USA ( host institution ), Chapman, Sean, Lindbeck, Alwyn G.C., Dawson, William O.   +3 more
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Structure and Role of O-Linked Glycans in Viral Envelope Proteins

Annual Review of Virology, 2023
N- and O-glycans are both important constituents of viral envelope glycoproteins. O-linked glycosylation can be initiated by any of 20 different human polypeptide O-acetylgalactosaminyl transferases, resulting in an important functional O-glycan heterogeneity.
Olofsson, Sigvard, Bally, Marta, Trybala, Edward, Bergström, Tomas   +3 more
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Characterisation of a rare, reassortant human G10P[14] rotavirus strain detected in Honduras

Memorias do Instituto Oswaldo Cruz
BACKGROUND Although first detected in animals, the rare rotavirus strain G10P[14] has been sporadically detected in humans in Slovenia, Thailand, United Kingdom and Australia among other countries. Earlier studies suggest that the strains found in humans
Osbourne Quaye, Sunando Roy, Kunchala Rungsrisuriyachai, Mathew D Esona, Ziqian Xu, Ka Ian Tam, Dina J Castro Banegas, Gloria Rey-Benito, Michael D Bowen   +8 more
doaj   +1 more source

LUJO HEMORRHAGIC FEVER

Вопросы вирусологии, 2017
Lujo hemorrhagic fever (LHF) is a viral disease accompanied with fever, headache, vomiting, diarrhea, arthralgia, myalgia and numerous signs of hemorrhagic syndrome. LHF causes a clinical syndrome remarkably similar to Lassa hemorrhagic fever.
T. E. Sizikova, V. N. Lebedev, S. I. Syromyatnikova, S. V. Borisevich   +3 more
doaj   +1 more source

The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins [PDF]

Nature Communications, 2019
AbstractLipid membrane fusion is an essential function in many biological processes. Detailed mechanisms of membrane fusion and the protein structures involved have been mainly studied in eukaryotic systems, whereas very little is known about membrane fusion in prokaryotes.
Eduardo A Bignon, F Hurtado, Pentti Somerharju, Karl Harlos, Daniel K. Clare, F. de Haas, M Molin, Abhay Kotecha, Elina Roine, Sai Li, Sai Li, Thomas S. Walter, Jonathan M. Grimes, Meng Jung Li, Nicole D. Tischler, Juha T. Huiskonen, Juha T. Huiskonen, Dennis H. Bamford, David I. Stuart, K. El Omari   +19 more
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Structures of viral membrane proteins by high-resolution cryoEM [PDF]

Current Opinion in Virology, 2014
Cryo electron microscopy (cryoEM) has emerged as an excellent tool for resolving high-resolution three-dimensional structures of membrane proteins in a lipid-containing environment with interacting partners. The near atomic resolution structures of Venezuelan equine encephalitis virus and dengue virus revealed transmembrane helices in lipid bilayers ...
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HIV-1 Structural Proteins or Cell-Signaling Factors? That Is the Question!

Current Issues in Molecular Biology
The biological activity of structural HIV-1 proteins is not limited to ensuring a productive viral infection but also interferes with cellular homeostasis through intra- and extracellular signaling activation.
Michele Pellegrino, Francesca Giordano, Francesca De Amicis, Maria Marra, Paola Tucci, Stefania Marsico, Stefano Aquaro   +6 more
doaj   +1 more source

Integrated analysis to study the interplay between post-translational modifications (PTM) in hepatitis C virus proteins and hepatocellular carcinoma (HCC) development

Scientific Reports, 2022
Many PTMs dysregulation is known to be the major cause of many cancers including HCV induced HCC. PTMs of hepatitis C virus (HCV) regions NS3/4A, NS5A and NS5B are crucial for proper protein functions and replication that directly affect the generation ...
Aqsa Ikram, Bisma Rauff, Badr Alzahrani, Faryal Mehwish Awan, Ayesha Obaid, Anam Naz, Salik Javed Kakar, Hussnain Ahmed Janjua   +7 more
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Recognition of mRNA cap structures by viral and cellular proteins

Journal of General Virology, 2005
Most cellular and eukaryotic viral mRNAs have a cap structure at their 5′ end that is critical for efficient translation. Cap structures also aid in mRNA transport from nucleus to cytoplasm and, in addition, protect the mRNAs from degradation by 5′ exonucleases.
George G. Brownlee, Pierre Fechter
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Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source