Results 61 to 70 of about 1,666,541 (346)
Viral degradasome hijacks mitochondria to suppress innate immunity [PDF]
Cell Research, 2013 The balance between the innate immunity of the host and the ability of a pathogen to evade it strongly influences pathogenesis and virulence. The two nonstructural (NS) proteins, NS1 and NS2, of respiratory syncytial virus (RSV) are critically required for RSV virulence.
Ramansu, Goswami +7 more
openaire +2 more sources
Journal of the International AIDS Society, 2020 Mental health problems are prevalent in adolescents living with HIV (ALHIV), often remain untreated, and may negatively affect antiretroviral therapy (ART) adherence and viral suppression.
A. Haas +11 more
semanticscholar +1 more source
A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins
FEBS Letters, EarlyView.We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue +6 more
wiley +1 more source
Reduction in time to viral suppression among persons living with HIV in Jamaica between 2017-2019.
PLOS Global Public HealthIntroductionHIV viral suppression is important for effective treatment and for reducing new infections. In 2019, only 66% of persons on antiretroviral treatment (ART) in Jamaica were virally suppressed.
Anya Cushnie +3 more
doaj +1 more source
BMC Public Health, 2021 Background The East Central (EC) region of Uganda has the least viral suppression rate despite having a relatively low prevalence of human immunodeficiency virus (HIV).
Geoffrey Ndikabona +3 more
doaj +1 more source
Science Translational Medicine, 2020 In virally suppressed HIV-infected individuals on antiretroviral drug therapy, platelets harboring HIV correlate with poor immunological recovery. Hidden in plain sight Human platelets carry out several immune functions as well as hemostasis and interact
F. Real +18 more
semanticscholar +1 more source
Viral suppression of RNA silencing in plants
Molecular Plant Pathology, 2004 SUMMARY RNA silencing is a conserved eukaryotic pathway involved in suppression of gene expression via sequence‐specific interactions that are mediated by nt 21–24‐long RNA molecules. In plants, cell‐autonomous and noncell‐autonomous steps of RNA silencing form the basis of an elaborate immune system that is activated by, and targeted
Guillaume, Moissiard, Olivier, Voinnet
openaire +2 more sources
Hematopoietic (stem) cells—The elixir of life?
FEBS Letters, EarlyView.The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source
HIV-1 nef suppression by virally encoded microRNA [PDF]
Retrovirology, 2004 Abstract Background MicroRNAs (miRNAs) are 21~25-nucleotides (nt) long and interact with mRNAs to trigger either translational repression or RNA cleavage through RNA interference (RNAi), depending on the degree of complementarity with the target mRNAs.
Brisibe Ebiamadon +7 more
openaire +3 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source