Results 31 to 40 of about 8,443,463 (315)

Detection of low-load Epstein-Barr virus in blood samples by enriched recombinase aided amplification assay

AMB Express, 2022
Key points 1. The RAA with an enrichment step that utilizes magnetic beads coated with M1 protein. 2. A very effective method for detecting low-load virus in blood samples. 3. The first report describing virus detection using this method.
Jing-yi Li, Xiao-ping Chen, Yan-qing Tie, Xiu-li Sun, Rui-qing Zhang, An-na He, Ming-zhu Nie, Guo-hao Fan, Feng-yu Li, Feng-yu Tian, Xin-xin Shen, Zhi-shan Feng, Xue-jun Ma   +12 more
doaj   +1 more source

MiRNA expression profiles in the brains of mice infected with scrapie agents 139A, ME7 and S15

Emerging Microbes and Infections, 2016
MicroRNA (miRNA) is a class of non-coding endogenous small-molecule single-stranded RNA that regulates complementary mRNA through degradation or translation of the mRNA targets. Usually, miRNAs show remarkable cell and tissues specificity.
Chen Gao, Jing Wei, Bao-Yun Zhang, Qiang Shi, Cao Chen, Jing Wang, Qi Shi, Xiao-Ping Dong   +7 more
doaj   +1 more source

Therapeutic implications of prion diseases

Biosafety and Health, 2021
Prions are unconventional infectious agents that cause lethal transmissible neurodegenerative diseases in human and animals. Prions can be distinguished from other known pathogens by their lack of nucleic acids.
Cao Chen, Xiaoping Dong
doaj   +1 more source

A multi-variant, viral dynamic model of genotype 1 HCV to assess the in vivo evolution of protease-inhibitor resistant variants [PDF]

, 2010
Variants resistant to compounds specifically targeting HCV are observed in clinical trials. A multi-variant viral dynamic model was developed to quantify the evolution and in vivo fitness of variants in subjects dosed with monotherapy of an HCV protease ...
Stefan Zeuzem, Randle, John C. R., Randle John C. R., Lin, Chao, Kwong Ann D., Bambang S Adiwijaya, John C. R. Randle, Sarrazin, Christoph, Paul R. Caron, Herrmann Eva, Zeuzem Stefan, Christoph Sarrazin, Garg Varun, Kieffer, Tara, Brian Hare, Hare, Brian, Varun Garg, Lin Chao, Kieffer Tara, Herrmann, Eva, Caron, Paul R., Kwong, Ann D., Tara Kieffer, Ann D Kwong, Sarrazin Christoph, Chao Lin, Bambang S. Adiwijaya, Adiwijaya, Bambang S., Hare Brian, Paul R Caron, Caron Paul R., Garg, Varun, Eva Herrmann, Ann D. Kwong, John C R Randle, Adiwijaya Bambang S., Zeuzem, Stefan   +36 more
core   +2 more sources

Non-Structural Protein 2B of Human Rhinovirus 16 Activates Both PERK and ATF6 Rather Than IRE1 to Trigger ER Stress

Viruses, 2019
To understand the underlying mechanisms of endoplasmic reticulum (ER) stress caused by human rhinovirus (HRV) 16 and non-structural transmembrane protein 2B, the expressions of ER chaperone glucose-regulated protein 78 (GRP78) and three signal ...
Juan Song, Miaomiao Chi, Xiaonuan Luo, Qinqin Song, Dong Xia, Bingtian Shi, Jun Han   +6 more
doaj   +1 more source

Hepatitis C viral evolution in genotype 1 treatment-naïve and treatment-experienced patients receiving telaprevir-based therapy in clinical trials [PDF]

, 2012
Background: In patients with genotype 1 chronic hepatitis C infection, telaprevir (TVR) in combination with peginterferon and ribavirin (PR) significantly increased sustained virologic response (SVR) rates compared with PR alone.
Bambang Adiwijaya, Joan Spanks, Ann Tigges (171451), Ann Tigges, Joan Spanks (171460), Zhang Eileen Z., Maria Beumont, Bartels Doug J., De Meyer, Sandra, Jacobson, Ira M., Ira M. Jacobson (171497), Kieffer Tara L., Ghys Anne, Min Jiang, Sullivan James C., James C Sullivan, Doug J Bartels, Beumont, Maria, Dorrian Jennifer, Dierynck, Inge, Nathalie Adda, Adiwijaya, Bambang, Kauffman, Robert S., Kwong, Ann D., Min Jiang (56794), Jennifer Dorrian (171464), James C. Sullivan (13811), Bambang Adiwijaya (171470), Sherman, Kenneth E., Dierynck Inge, Ann D. Kwong (171515), Ghys, Anne, Tara L Kieffer, Gaston Picchio, Maria Beumont (171481), Spanks Joan, Inge Dierynck, Kenneth E Sherman, Robert S Kauffman, Adda Nathalie, Sherman Kenneth E., Stefan Zeuzem (22856), Stefan Zeuzem, Inge Dierynck (171456), Jiang, Min, Robert S. Kauffman (171487), Gaston Picchio (171523), Kwong Ann D., Zhang, Eileen Z., Sandra De Meyer (171427), Tigges, Ann, Zeuzem Stefan, Dorrian, Jennifer, Kenneth E. Sherman (171505), Sandra De Meyer, Nathalie Adda (171493), Jacobson Ira M., Adiwijaya Bambang, Ira M Jacobson, Bartels, Doug J., Doug J. Bartels (171434), Eileen Z Zhang, Jennifer Dorrian, De Meyer Sandra, Tigges Ann, Sullivan, James C., Picchio, Gaston, Ann D Kwong, Anne Ghys (171476), Adda, Nathalie, Eileen Z. Zhang (171445), Kieffer, Tara L., Spanks, Joan, Picchio Gaston, Kauffman Robert S., Anne Ghys, Tara L. Kieffer (171419), Jiang Min, Zeuzem, Stefan, Beumont Maria   +79 more
core   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

Sharing CD4+ T Cell Loss: When COVID-19 and HIV Collide on Immune System

Frontiers in Immunology, 2020
COVID-19 is a distinctive infection characterized by elevated inter-human transmission and presenting from absence of symptoms to severe cytokine storm that can lead to dismal prognosis.
Xiaorong Peng, Xiaorong Peng, Xiaorong Peng, Jing Ouyang, Stéphane Isnard, Stéphane Isnard, Stéphane Isnard, John Lin, John Lin, Brandon Fombuena, Brandon Fombuena, Biao Zhu, Jean-Pierre Routy, Jean-Pierre Routy, Jean-Pierre Routy   +14 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The rate of viral rebound after attainment of an HIV load < 50 copies/mL according to specific antiretroviral drugs in use: Results from a multicenter cohort study [PDF]

, 2005
Background. Relatively few data are available on the association between the use of specific antiretroviral drugs and the rate of viral rebound in those attaining a viral load (VL) 500 copies/ mL).
Smith, CJ, Smith, C J, Phillips, AN, Porter, K, Scullard, G, Hill, T, Fisher, M, Phillips, A N, Easterbrook, P, Johnson, MA, Gilson, R, Sabin, C A, Gazzard, B, United Kingdom HIV Cohort Study, Matthias, R, Sabin, CA, Johnson, M A   +16 more
core   +1 more source