Results 91 to 100 of about 614,007 (276)

Critical Roles of O‐Acetylation Revealed by Synthetic Trisaccharide Antigens for a Broad‐Spectrum Anti‐Salmonella Vaccine

Advanced Science, EarlyView.
A synthetic glycoconjugate vaccine based on a diacetylated Salmonella trisaccharide elicits broadly protective antibodies against four major human pathogenic serovars. Mechanistic studies identify 2,3‐di‐O‐acetylation of rhamnose as a critical determinant of antigen recognition and breadth of protection, establishing a new strategy for broad‐spectrum ...
Xingling Pan, Soham Maity, Herbert Kavunja, Yuvarani Murali, Ting‐An Chen, Chang‐xin Huo, Scott M. Baliban, Xuefei Huang   +7 more
wiley   +1 more source

Detaching Photosensitive Nanoparticles from Cells Prevents Them from Remaining in Cells after Photoporation

Advanced Science, EarlyView.
Phenylboronic acid‐functionalized gold nanoparticles reversibly attach to cell‐surface glycans, enhancing photoporation‐mediated intracellular delivery. After irradiation, ATP competitively disrupts the boronic ester interactions and removes cell‐associated nanoparticles, markedly reducing residual gold.
Tao Lu, Mina Nikolić, Baihao Huang, Deep Punj, Herlinde De Keersmaecker, Thibaut Van Acker, Wenjia Xie, Florian Vanlauwe, Phillip Blondeel, Liesl De Graeve, Félix Sauvage, Ranhua Xiong, Chaobo Huang, Frank Vanhaecke, Kevin Braeckmans, Stefaan C. De Smedt   +15 more
wiley   +1 more source

H4K12 Lactylation Regulates NDUFS7 to Drive Microglia Reverse Electron Transport in Spinal Cord Injury

Advanced Science, EarlyView.
Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong, Zhichen Jiang, Zhouwei Wu, Chenyu Wu, Jiang Liu, Kaijie Guo, Yihui Liang, Shaobo Xu, Yuchen Jin, Yong Xiao, Lei Guo, Hui Xu, Sunren Sheng, Chenggui Wang   +13 more
wiley   +1 more source

Correlating HIV tropism with immunological response under combination antiretroviral therapy [PDF]

, 2016
Objectives A significant percentage of patients infected with HIV-1 experience only suboptimal CD4 cell recovery while treated with combination therapy (cART).
Böni, J, Gorgievski-Hrisoho, M., Gorgievski-Hrisoho, M, Martinetti, G., Martinetti, G, Bader, J., Klimkait, T, Swiss HIV Cohort, Study, Boni, J., Klimkait, T., Böni, Jürg, Battegay, M., Bader, J, Schöni-Affolter, F, Schoni-Affolter, F., Battegay, M, Gorgievski, Meri, Swiss, H. I. V. Cohort Study   +17 more
core   +2 more sources

CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells

Advanced Science, EarlyView.
AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu, Xinyu Zhang, Fang Dong, Nenghao Shen, Jun Zhou, Zihan Xi, Zhenghao Wu   +6 more
wiley   +1 more source

Infectious bronchitis-virus-like QX strain transmission, pathogenesis, replication, and host miRNA biogenesis pathway hijacking mechanism

Frontiers in Cellular and Infection Microbiology
The infectious bronchitis virus (IBV) is an acute, highly contagious, single-stranded RNA (ssRNA) gammacoronavirus mainly transmitted to chickens through the intranasal route. Positive-sense ssRNA viruses primarily act on mRNA and enhance the replication
Asad Khan, Asad Khan, Asad Khan, Iftikhar Ali Khan, Chao Huang, Chao Huang, Qihui Luo, Qihui Luo, Abdul Qadeer, Lanlan Jia, Lanlan Jia, Mourad A. M. Aboul-Soud, Noorah A. Alkubaisi, Zhengli Chen, Zhengli Chen   +14 more
doaj   +1 more source

Kyasanur Forest disease virus non-mouse animal models: a pilot study

BMC Research Notes, 2020
Objectives Mouse models have delivered variable recapitulation of Kyasanur Forest disease (KFD) pathology and consistently demonstrated neurological involvement which may be a limited feature of human disease.
A. M. Nikiforuk, K. Tierny, T. A. Cutts, D. K. Kobasa, S. S. Theriault, B. W. M. Cook   +5 more
doaj   +1 more source

Cellular tropism of HIV-1 mediated and contrained by coreceptor dependencies [PDF]

, 2005
The ability of cells to migrate to specific sites is critical for the proper functioning of both innate and adaptive immune responses in primates. This selective responsiveness is largely orchestrated by small proteins known as chemokines, which direct ...
Nolan, D., Gaudieri, S., Lucas, A.D., Rauch, A., Mallal, S.   +4 more
core  

Validation of replicative phenotyping to detect and assign HIV-1 resistance in clinical specimens [PDF]

, 2009
The ability of HIV-1 to develop resistance to antiretroviral drugs has limited the overall efficacy of combination therapy to suppress viral replication.
Louvel, Séverine
core   +1 more source

A Biomimetic cRGDyk‐Engineered Platelet Nanoplatform for ACAD11 Delivery to Trigger Pyroptosis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A biomimetic platelet nanoplatform (OE‐ACAD11@R‐PLT) is developed for targeted hepatocellular carcinoma immunotherapy. By selectively delivering therapeutic plasmids, this system induces mitochondrial dysfunction and triggers robust NLRP3/Caspase‐1/GSDMD‐mediated pyroptosis in tumor cells.
Hongyi Bao, Wei Feng, Wei Zong, Yi Li, Xinyue Qin, Xinyue Wang, Yubo Yang, Guanhua Chen, Yiting Hou, Xuan Tan, Lin Chen, Ming Zhang, Feng Wang   +12 more
wiley   +1 more source