Results 11 to 20 of about 614,007 (276)

Viral interferon antagonism shapes host tropism.

PLoS Pathogens
Outbreaks of zoonotic viruses in human populations highlight the need to understand the molecular factors that influence viral host tropism and interspecies transmission.
Felix Streicher, Amandine Chantharath, Nolwenn Jouvenet   +2 more
doaj   +6 more sources

A Neonatal Murine Model for Caprine Enterovirus Infection and the Viral Tissue Tropism

Viruses, 2023
As the first caprine enterovirus identified from goat herds characterized by severe diarrhea with a high morbidity and mortality rate, the underlying pathogenesis and tissue tropism for CEV-JL14 remains largely unknown.
Qun Zhang, Fan Zhang, Xiaoran Chang, Junying Hu, Zhiyuan Zhang, Xuyuan Cui, Xuebo Zheng, Xinping Wang   +7 more
doaj   +2 more sources

Filovirus tropism: Cellular molecules for viral entry [PDF]

Frontiers in Microbiology, 2012
In human and nonhuman primates, filoviruses (Ebola and Marburg viruses) cause severe hemorrhagic fever．Recently, other animals such as pigs and some species of fruit bats have also been shown to be susceptible to these viruses. While having a preference
Ayato eTakada
doaj   +3 more sources

Oxygen sensing and viral replication: implications for tropism and pathogenesis [PDF]

Viruses, 2020
The ability to detect and respond to varying oxygen tension is an essential prerequisite to life. Several mechanisms regulate the cellular response to oxygen including the prolyl hydroxylase domain (PHD) /factor inhibiting HIF (FIH)-hypoxia inducible ...
Liu, Jian Rui, Balfe, Peter, Peter Balfe, Schilling, Mirjam, Peter Jianrui Liu, McKeating, Jane, Jane A McKeating, Mirjam Schilling   +7 more
core   +5 more sources

LCMV glycosylation modulates viral fitness and cell tropism. [PDF]

PLoS ONE, 2013
The glycoprotein (GP) of arenaviruses is glycosylated at 11 conserved N-glycosylation sites. We constructed recombinant lymphocytic choriomeningitis virus (rLCMV) featuring either additions or deletions of these N-glycans to investigate their role in the
Cyrille J Bonhomme, Kristeene A Knopp, Lydia H Bederka, Megan M Angelini, Michael J Buchmeier   +4 more
doaj   +6 more sources

Species tropism of HIV-1 modulated by viral accessory proteins [PDF]

Frontiers in Microbiology, 2012
Human immunodeficiency virus type 1 (HIV-1) is tropic and pathogenic only for humans, and does not replicate in macaque monkeys routinely used for experimental infections.
Naoya Doi, Sachi Fujiwara, Yui eMatsumoto, Yui Matsumoto, Sachi eFujiwara, Yosuke Sakai, Akio eAdachi, Masako Nomaguchi, Masako eNomaguchi, Yosuke eSakai, Akio Adachi, Naoya eDoi   +11 more
core   +5 more sources

Modulation of Cellular Tropism and Innate Antiviral Response by Viral Glycans [PDF]

Journal of Innate Immunity, 2009
Arthropod-borne viruses (arboviruses) are a significant cause of human and animal disease worldwide. Multiple interactions between virus and the host innate immune system ultimately determine the pathogenesis and clinical outcome of the infection ...
Heise, Mark, Rogers, Kristin M.
core   +4 more sources

Revisiting endothelial tropism of SARS-CoV-2 using a cell-specific hACE2 mouse model [PDF]

Microbiology Spectrum
Severe COVID-19 is frequently associated with vascular complications, raising ongoing debate about whether SARS-CoV-2 can directly infect endothelial cells and thereby contribute to disease pathogenesis.
Sahine Lameire, Nincy Debeuf, Julie Deckers, Caroline De Wolf, Manon Vanheerswynghels, Wendy Toussaint, Lize De Vlieger, Lien Van Hoecke, Arnout Bruggeman, Sieglinde De Cae, Bert Schepens, Stijn Vanhee, Bart N. Lambrecht   +12 more
doaj   +2 more sources

Early Permissiveness of Central Nervous System Cells to Measles Virus Infection Is Determined by Hyperfusogenicity and Interferon Pressure

Viruses, 2023
The cessation of measles virus (MeV) vaccination in more than 40 countries as a consequence of the COVID-19 pandemic is expected to significantly increase deaths due to measles.
Marion Ferren, Alexandre Lalande, Mathieu Iampietro, Lola Canus, Didier Decimo, Denis Gerlier, Matteo Porotto, Cyrille Mathieu   +7 more
doaj   +1 more source

Host–Pathogen Interactions Influencing Zoonotic Spillover Potential and Transmission in Humans

Viruses, 2023
Emerging infectious diseases of zoonotic origin are an ever-increasing public health risk and economic burden. The factors that determine if and when an animal virus is able to spill over into the human population with sufficient success to achieve ...
Beatriz Escudero-Pérez, Alexandre Lalande, Cyrille Mathieu, Philip Lawrence   +3 more
doaj   +1 more source