Limited evolution of inferred HIV-1 tropism while viremia is undetectable during standard HAART therapy. [PDF]
PLoS ONE, 2014 BACKGROUND:HIV patients on suppressive antiretroviral therapy have undetectable viremia making it impossible to screen plasma HIV tropism if regimen change is required during suppression.
Guinevere Q Lee +8 more
doaj +1 more source
Unique Tropism and Entry Mechanism of Mumps Virus
Viruses, 2021 Mumps virus (MuV) is an important human pathogen that causes parotitis, orchitis, oophoritis, meningitis, encephalitis, and sensorineural hearing loss. Although mumps is a vaccine-preventable disease, sporadic outbreaks have occurred worldwide, even in ...
Marie Kubota, Takao Hashiguchi
doaj +1 more source
Viral chimeras decrypt the role of enterovirus capsid proteins in viral tropism, acid sensitivity and optimal growth temperature [PDF]
PLoS Pathogens, 2018 Caroline Tapparel +2 more
exaly +2 more sources
Type I interferon shapes brain distribution and tropism of tick-borne flavivirus
Nature Communications, 2023 Viral tropism within the brain and the role(s) of vertebrate immune response to neurotropic flaviviruses infection is largely understudied. We combine multimodal imaging (cm-nm scale) with single nuclei RNA-sequencing to study Langat virus in wildtype ...
Nunya Chotiwan +15 more
doaj +1 more source
Accelerated in vivo proliferation of memory phenotype CD4+ T-cells in human HIV-1 infection irrespective of viral chemokine co-receptor tropism. [PDF]
, 2013 CD4(+) T-cell loss is the hallmark of HIV-1 infection. CD4 counts fall more rapidly in advanced disease when CCR5-tropic viral strains tend to be replaced by X4-tropic viruses.
de Lara, C +27 more
core +1 more source
Progress in the use of adeno-associated viral vectors for gene therapy [PDF]
, 2004 The development of safe and efficient gene transfer vectors is crucial for the success of gene therapy trials. A viral vector system promising to meet these requirements is based on the apathogenic adeno-associated virus (AAV-2), a member of the ...
Markus Braun-Falco +7 more
core +1 more source
Block of death-receptor apoptosis protects mouse cytomegalovirus from macrophages and is a determinant of virulence in immunodeficient hosts. [PDF]
, 2012 The inhibition of death-receptor apoptosis is a conserved viral function. The murine cytomegalovirus (MCMV) gene M36 is a sequence and functional homologue of the human cytomegalovirus gene UL36, and it encodes an inhibitor of apoptosis that binds to ...
Ebermann, L. +37 more
core +2 more sources
Adipose Tissue in SARS-CoV-2 Viral Tropism, Viral Replication, and the Concept of a Viral Reservoir: An Update. [PDF]
Obesity (Silver Spring)ABSTRACT Since the onset of the COVID‐19 pandemic, obesity has been consistently associated with worse clinical outcomes. In 2020, we hypothesized that adipose tissue (AT) might serve as a viral reservoir and amplifier of immune responses in SARS‐CoV‐2 infection. Five years on, accumulating evidence supports this hypothesis.
Maher LC, Ryan PM, Caplice NM.
europepmc +3 more sources
HCMV spread and cell tropism are determined by distinct virus populations. [PDF]
, 2011 Human cytomegalovirus (HCMV) can infect many different cell types in vivo. Two gH/gL complexes are used for entry into cells. gH/gL/pUL(128,130,131A) shows no selectivity for its host cell, whereas formation of a gH/gL/gO complex only restricts the ...
Ulrich H Koszinowski +10 more
core +2 more sources
How EBV Infects: The Tropism and Underlying Molecular Mechanism for Viral Infection
, 2022 The Epstein–Barr virus (EBV) is associated with a variety of human malignancies, including Burkitt’s lymphoma, Hodgkin’s disease, nasopharyngeal carcinoma and gastric cancers.
Xie, Chu +9 more
core +1 more source