Results 211 to 220 of about 614,007 (276)
ABSTRACT Background and Aims Pathogenic viruses represent a principal etiology of acute respiratory tract disease. Concurrent detection of multiple respiratory pathogens has been associated with diagnostic challenges, therapeutic complications, and unfavorable outcomes in patients with COVID‐19. This investigation aimed to characterize the frequency of
Ardalan Maleki Chegeni +4 more
wiley +1 more source
Emerging CCR5-Based Therapeutic Potential of JAK/STAT Inhibitors and CCR5Δ32 Hematopoietic Stem Cell Transplantation. [PDF]
Khalid K +6 more
europepmc +1 more source
ABSTRACT Background Pancreatic cancer (PC) is on the rise worldwide, with significant improvements in survival rates still awaited. Most patients are diagnosed at an advanced stage, often with liver metastases (LM), associated with poor prognosis and immunosuppression.
Laura K. Kjær +6 more
wiley +1 more source
A naturally occurring feline leukaemia virus subgroup A variant exhibits broad mammalian cellular tropism and utilizes canine thiamine transporter 1. [PDF]
Kanemura Y, Nakagawa S, Miyazawa T.
europepmc +1 more source
ABSTRACT Patients in intensive care units (ICU) under mechanical ventilation, particularly those with SARS‐CoV‐2 infection, are highly susceptible to Herpes simplex virus (HSV) reactivation. Given the lack of data on the SARS‐CoV‐2 Omicron and Delta variants, this study aimed to assess the prevalence of pulmonary HSV reactivation in mechanically ...
Bastien Zarlenga +14 more
wiley +1 more source
• EV content maintains cellular homeostasis and is involved in several disease onset and progression. • miRNA export in EVs depends on: RNA‐binding proteins recognizing motif sequences and on epitranscriptomic modifications. • The disclosure of delivery mechanisms is crucial for developing personalized EV‐based therapeutic tools. ABSTRACT Extracellular
Sabrina Garbo +4 more
wiley +1 more source
Hyperglycemia in Cats Infected by SARS-CoV-2: Pancreatic Alterations and Potential Antiviral Therapeutics. [PDF]
Onodera T, Seo S, Sakudo A, Toniolo A.
europepmc +1 more source
Organoids: Current Applications and Future Directions
Organoids are three‐dimensional multicellular structures derived from stem cells or primary tissues that recapitulate key structural and functional features of native organs. Advances in stem cell biology, biomaterials, and bioengineering have established organoids as powerful platforms for studying human development and disease mechanisms, drug ...
Yueqi Leng +14 more
wiley +1 more source
Our study reveals a novel mechanism by which MSC‐derived EVs alleviate NaIO3‐induced dry AMD‐like pathology. MSC‐EVs deliver miR‐486‐3p into retinal cells to directly inhibit the ferroptosis‐promoting target gene Lcn2. Concurrently, downregulated Lcn2 restores intracellular Gpx4 expression, thereby suppressing ferroptosis and rescuing retinal ...
Zheng Li +6 more
wiley +1 more source
CCR5 as a Therapeutic Target in HIV Disease: From CRISPR/Cas9 Gene Editing to Maraviroc-Mediated Inhibition. [PDF]
Iqbal U +4 more
europepmc +1 more source

