Results 221 to 230 of about 614,007 (276)

Advancing In Vivo Chimeric Antigen Receptor T‐Cell Engineering to Accelerate Clinical Translation

MedComm, Volume 7, Issue 10, October 2026.
In vivo CAR‐T cell generation directly engineers endogenous T cells using pre‐manufactured gene delivery vectors that target T cells and deliver CAR‐encoding genetic material. The resulting CAR‐T cells expand in vivo and mediate antigen‐specific cytotoxicity.
Zhenxin Bai, Ming Yi, Shengtao Hu, Dixuan Xue, Luxin Wei, Lifeng Zhang, Zhijun Dai   +6 more
wiley   +1 more source

Intratumoral Microbiota in Fueling Cancer and Steering Treatment Response

MedComm, Volume 7, Issue 10, October 2026.
Emerging research underscores the tumor‐specific colonization of microbiota and the role of intratumoral microbiota in cancer development and treatment resistance across multiple malignancies. Here, we provide a systematic review exploring the latest biotechnological advancements for studying low‐abundance intratumoral microbiota, their origins ...
Minhui Xu, Jie Yu, Ying Chen, Shengfang Ge, Lin Ye, Yefei Wang, Yixiong Zhou, Renbing Jia   +7 more
wiley   +1 more source

Co-receptor usage in distinct phylogenetic clusters of HIV-1 CRF01_AE is associated with differential immune reconstitution after antiretroviral therapy. [PDF]

Microbiol Spectr
Liu Y, Lu J, Qiu T, Hu Z, Li W, Li X, Du G, Zhao M, Ma H, Wei P, Yang D, Ge Y.   +11 more
europepmc   +1 more source

mRNA Therapeutics for Skin Rejuvenation: From Aging Atlases to Clinical Translation

Experimental Dermatology, Volume 35, Issue 10, October 2026.
ABSTRACT Skin aging is a multifactorial process characterized by the progressive decline of tissue structure, function and regenerative capacity. Although numerous interventions have been developed to improve the clinical manifestations of aging, most primarily alleviate downstream consequences rather than directly targeting the molecular mechanisms ...
Fabiana Boncimino, Stefano Sol, Kristina Todorova, Anna Mandinova   +3 more
wiley   +1 more source

Expanding the Fish‐Brain Invitrome With the Senegalese Sole SsB‐1 Cell Line—A Versatile Model for Neurotropic Virus Research

Journal of Fish Diseases, Volume 49, Issue 10, October 2026.
ABSTRACT Cell lines are essential tools for studying animal physiology and immunopathology, reducing the use of live animals and supporting the 3Rs principle of reduction, refinement, and replacement. The Senegalese sole (Solea senegalensis), a relevant species for Spanish aquaculture diversification, lacks established in vitro models. We developed SsB‐
Yulema Valero, Alberto Cuesta
wiley   +1 more source

Powassan Virus Infects Mouse Testes and Reveals a Protective Role for Phagocytic Cells. [PDF]

Viruses
Hager-Soto EE, Arroyave E, Eyzaguirre E, Saldarriaga OA, Freiberg AN, Rossi SL.   +5 more
europepmc   +1 more source

Fish Poxviruses on the Rise: Prospects for Aquatic Health

Journal of Fish Diseases, Volume 49, Issue 10, October 2026.
ABSTRACT Fish poxviruses are increasingly recognised as emerging pathogens of fish and should be considered in cases of unexplained gill or skin pathology. Carp edema virus (CEV), the causative agent of koi sleepy disease in common carp and koi (Cyprinus carpio), represents the first known example.
Mikolaj Adamek, Marek Matras, Oluwaseun Christianah Ojelade, Motohiko Sano, Mona C. Gjessing, Tomas Korytar, Alberto Falco, Krzysztof Rakus, Verena Jung‐Schroers, Andor Doszpoly   +9 more
wiley   +1 more source

Assessment of influenza virus and coronavirus tropism, replication competence and disease severity in <i>ex vivo</i> and <i>in vitro</i> cultures of the human respiratory tract. [PDF]

J Gen Virol
Kuok DIT, Ma APY, Ching RHH, Ng KC, Lee JW, Matthay MA, Guan Y, Nicholls JM, Poon LLM, Peiris JSM, Hui KPY, Chan MCW.   +11 more
europepmc   +1 more source

In Situ Hybridization and RT‐PCR Detection of Nervous Necrosis Virus in Fourfinger Threadfin, Eleutheronema tetradactylum, in Taiwan

Journal of Fish Diseases, Volume 49, Issue 10, October 2026.
ABSTRACT Between April and July 2020, suspected outbreaks of nervous necrosis virus (NNV) infection were observed in fourfinger threadfin (Eleutheronema tetradactylum) fingerling hatcheries in Pingtung County, southern Taiwan. Affected fish exhibited spiral swimming behaviour and abdominal distension, resulting in mortality rates between 50% and 100 ...
Chia‐Yu Hsieh, Shang‐Ting Wu, Chun‐Ying Lin   +2 more
wiley   +1 more source

Ad5/52s fiber substitution alters Ad5 tropism, bioavailability, and plasma sensitivity. [PDF]

Mol Ther Adv
Garcia-Moure M, Rodríguez E, Barriga FM, Chillón G, Rey JD, Batlle E, Bosch A, Chillón M.   +7 more
europepmc   +1 more source