Results 241 to 250 of about 614,007 (276)

From Organoids to Organ-on-Chip: Advancing Human-Relevant Models for Viral Pathogenesis and Antiviral Drug Discovery. [PDF]

Cells
Tiwari V, Choe J, Vora A, Kataki I, Roujouleh SAL, Allenspach K, Swanson-Mungerson M, Volin MV, Sundaresan S.   +8 more
europepmc   +1 more source

SARS-CoV-2 Omicron BA.2.86 and JN.1 expand tropism in human proximal intestinal epithelium. [PDF]

Nat Commun
Hui KP, Ho JC, Ng KC, Chan JC, Ho TW, Ching RH, Poon LL, Peiris M, Nicholls JM, Chan MC.   +9 more
europepmc   +1 more source

Cytokine determinants of viral tropism

Nature Reviews Immunology, 2009
The specificity of a given virus for a cell type, tissue or species - collectively known as viral tropism - is an important factor in determining the outcome of viral infection in any particular host. Owing to the increased prevalence of zoonotic infections and the threat of emerging and re-emerging pathogens, gaining a better understanding of the ...
Diana L. Thomas, Mohamed R Mohamed, Eric Bartee   +2 more
exaly   +4 more sources

Tuft-cell-intrinsic and -extrinsic mediators of norovirus tropism regulate viral immunity [PDF]

Cell Reports, 2022
Murine norovirus (MNoV) is a model for human norovirus and for interrogating mechanisms of viral tropism and persistence. We previously demonstrated that the persistent strain MNoV(CR6) infects tuft cells, which are dispensable for the non-persistent ...
Madison S Strine, Craig B Wilen
exaly   +2 more sources

The SIV Envelope Glycoprotein, Viral Tropism, and Pathogenesis: Novel Insights from Nonhuman Primate Models of AIDS

Current HIV Research, 2018
Background: Cellular tropism of human immunodeficiency virus (HIV-1) is closely linked to interactions between the viral envelope glycoprotein (Env) with CD4 and chemokine receptor family members, CCR5 and CXCR4.
Claire Deleage, James A Hoxie, Adrienne E Swanstrom   +2 more
exaly   +2 more sources

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Viral Determinants of Cellular Tropism

Pathobiology, 2008
Cells of mononuclear phagocyte lineage are the predominant cell type producing human immunodeficiency virus type 1 (HIV-1) in extravascular tissues; HIV-1 infection of mononuclear phagocytes may be directly related to primary disease manifestations and also appears to contribute to the immune deficiency of AIDS. Whereas peripheral blood lymphocytes are
openaire   +2 more sources

Viral tropism for tuft cells

Nature Reviews Immunology, 2018
Norovirus infection of tuft cells in the intestinal epithelium can be promoted by type 2 cytokines.
openaire   +2 more sources

Viral tropisms in mouse brain cell cultures

Medical Microbiology and Immunology, 1982
Fourteen-day-old cultures of dissociated newborn mouse brain cells were infected separately with different strains of vaccinia virus and a strain of measles virus. Using the indirect immunofluorescence technique we found that under the experimental conditions in these cultures both measles and the neurotropic strain of vaccinia infected ...
C F, Beranek, R, Schäfer, L, Bologa, N, Herschkowitz   +3 more
openaire   +2 more sources

The effective factors in human‐specific tropism and viral pathogenicity in orthopoxviruses

Cell Biology International, 2022
AbstractThe orthopoxvirus (OPV) genus includes several species that infect humans, including variola, monkeypox, vaccinia, and cowpox. Variola and monkeypox are often life‐threatening diseases, while vaccinia and cowpox are usually associated with local lesions. The epidemic potential for OPVs may be lower than respiratory‐borne viruses or RNA viruses.
Soad Ghabeshi, Sorayya Ghasemi, Leila Mousavizadeh   +2 more
openaire   +2 more sources