Results 171 to 180 of about 2,747,170 (398)
Advanced Healthcare Materials, EarlyView.This review highlights recent advances in microfluidic technologies for modeling human aging and age‐related diseases. It explores how organ‐on‐chip platforms improve physiological relevance, enable rejuvenation strategies, facilitate drug screening, detect senescent cells, and identify biomarkers.
Limor Zwi‐Dantsis +5 more
wiley +1 more source
A helper-dependent adenovirus vector system: Removal of helper virus by Cre-mediated excision of the viral packaging signal [PDF]
, 1996 Robin J. Parks +5 more
openalex +1 more source
Advanced Healthcare Materials, EarlyView.Hybrid NPs are developed as efficient, scalable nanocarriers for in vitro microRNA delivery, ensuring high loading efficiency, controlled release, physiological and long‐term storage stability. They outperform commercial lipid‐based reagents in terms of transfection efficiency and biocompatibility.
Letizia Nicoletti +11 more
wiley +1 more source
Tumour modelling using viral vectors
Oncotarget, 2015 Human tumours typically harbour multiple mutations in tumour suppressor genes and oncogenes. Histologically identical tumours in different patients often exhibit different combinations of genetic alterations and it is now also evident that considerable genetic heterogeneity can exist between cells within individual tumours.
openaire +3 more sources
Viral Vectors Engineered for Gene Therapy
, 2023 Gene therapy has seen major progress in recent years. Viral vectors have made a significant contribution through efficient engineering for improved delivery and safety. A large variety of indications such as cancer, cardiovascular, metabolic, hematological, neurological, muscular, ophthalmological, infectious diseases, and immunodeficiency have been ...
openaire +2 more sources
Retroviral vectors preloaded with a viral receptor-ligand bridge protein are targeted to specific cell types [PDF]
, 1999 Adrienne L. Boerger +2 more
openalex +1 more source
Advanced Healthcare Materials, EarlyView.A mechanically active OsteoChondral Unit (OCU)‐on‐Chip platform mimicking the OCU's functional anatomy and the strain gradient across the osteochondral interface is presented. Upon compartment‐specific hyperphysiological compression, the model replicates mechanisms observed in osteoarthritis (OA) progression, such as calcium crystal accumulation ...
Andrea Mainardi +10 more
wiley +1 more source
Converging Paths of Viral and Non-viral Vector Engineering
Molecular Therapy, 2008 Vector design is the dominant technical domain of gene therapy research. Diverse ideas and strategies exist for engineering an ideal vector, because vector requirements are specific to particular gene therapy applications. However, these divergent starting points and design directions have begun to converge on one another to promote the entire vector ...
openaire +3 more sources
Gene delivery to in situ veins: Differential effects of adenovirus and adeno-associated viral vectors [PDF]
, 2000 Mohammad H. Eslami +5 more
openalex +2 more sources
Viruses mobilize plant immunity to deter nonvector insect herbivores. [PDF]
, 2019 A parasite-infected host may promote performance of associated insect vectors; but possible parasite effects on nonvector insects have been largely unexplored. Here, we show that Begomovirus, the largest genus of plant viruses and transmitted exclusively
Cai, Congxi +12 more
core +1 more source