Conditional repression of the E2 transcription unit in E1-E3-deleted adenovirus vectors is correlated with a strong reduction in viral DNA replication and late gene expression in vitro [PDF]
, 1997 Karola Rittner +3 more
openalex +1 more source
Advanced Materials, EarlyView.Convergence drawing is used to create flexible, microscale, multifunctional fiber‐based neural probes. Optimized materials selection enables individual devices to perform neural recording, electrical stimulation, optogenetics, fiber photometry, fluid delivery, and voltammetric neurotransmitter detection in rodents.
Nicolette Driscoll +16 more
wiley +1 more source
Frontiers in ImmunologyHigh levels of pre-existing antibodies are a major challenge for the application of viral vectors since they can severely limit their efficacy. To identify promising candidates among adeno-associated virus (AAV) based vectors for future gene therapies ...
Xiaoyan Wang +13 more
doaj +1 more source
Advanced Materials, EarlyView.This work explores the MOF landscape to select a single, optimal candidate for successfully delivering cancer drugs (gemcitabine, paclitaxel, SN‐38) into tough pancreatic tumors. Machine learning and simulations guide this search, demonstrating colloidal stability, excellent biocompatibility, cellular uptake, and sustained release.
Francesca Melle +9 more
wiley +1 more source
Fibronectin improves transduction of reconstituting hematopoietic stem cells by retroviral vectors: evidence of direct viral binding to chymotryptic carboxy-terminal fragments [PDF]
, 1996 Tassilo Moritz +6 more
openalex +1 more source
Machine‐Learning‐Aided Advanced Electrochemical Biosensors
Advanced Materials, EarlyView.Electrochemical biosensors are highly sensitive, portable, and versatile. Advanced nanomaterials enhance their performance, while machine learning (ML) improves data analysis, minimizes interference, and optimizes sensor design. Despite progress in both fields, their combined potential in diagnostics remains underexplored.
Andrei Bocan +9 more
wiley +1 more source
Evaluation of the Effect of β-Wrapin AS69 in a Mouse Model Based on Alpha-Synuclein Overexpression
BiomoleculesAggregation of the protein α-Synuclein (αSyn) is a hallmark of Parkinson’s disease (PD), dementia with Lewy bodies (DLB) and multiple systems atrophy, and alleviating the extent of αSyn pathology is an attractive strategy against neurodegeneration.
Lennart Höfs +7 more
doaj +1 more source
Engineering a serum-resistant and thermostable vesicular stomatitis virus G glycoprotein for pseudotyping retroviral and lentiviral vectors. [PDF]
, 2013 Vesicular stomatitis virus G glycoprotein (VSV-G) is the most widely used envelope protein for retroviral and lentiviral vector pseudotyping; however, serum inactivation of VSV-G pseudotyped vectors is a significant challenge for in vivo gene delivery ...
Hwang, B-Y, Schaffer, DV
core
Overexpression of the Glucose Transporter Gene with a Herpes Simplex Viral Vector Protects Striatal Neurons against Stroke [PDF]
, 1996 Matthew S Lawrence +7 more
openalex +1 more source
Topology in Biological Piezoelectric Materials
Advanced Materials, EarlyView.This review summarizes the topological structures in biological piezoelectric materials, covering morphology evolution, spatial arrangement, and biomimetic strategies. These topologies modulate structure‐property relationships across multiple scales, enabling performance enhancement and multifunctional integration.
Chen Chen +7 more
wiley +1 more source