Results 61 to 70 of about 146,116 (296)

Virome and Experimental Analysis Reveal Tryptophan‐Like Dissolved Organic Matter Contributes to the Persistence of Plant Viruses in River Water

Advanced Science, Volume 12, Issue 22, June 12, 2025.
Tryptophan‐like dissolved organic matter (Try‐like DOM), a key component of organic matter in river ecosystems, demonstrates significant protective effects against plant viruses. The protective mechanism operates via a “swimming firewall” mode, whereby free Try‐like DOM attenuates ultraviolet (UV) radiation and scavenges reactive oxygen species ...
Yujie Wang, Ming Chen, Liu Yang, Jun Ma, Jian Tang, Shengjun Wu, Chi He, J. Paul Chen   +7 more
wiley   +1 more source

Quantitative Imaging of Single, Unstained Viruses with Coherent X-rays

, 2008
Since Perutz, Kendrew and colleagues unveiled the structure of hemoglobin and myoglobin based on X-ray diffraction analysis in the 1950s, X-ray crystallography has become the primary methodology used to determine the 3D structure of macromolecules ...
A. C. Steven, Adrian Mancuso, Bagrat Amirbekian, Changyong Song, Huaidong Jiang, J. Kirz, Jianwei Miao, Li Peng, Ren Sun, Sanket S. Shah, Tetsuya Ishikawa, Z. Hong Zhou   +11 more
core   +1 more source

Integrative omics analysis of Pseudomonas aeruginosa virus PA5oct highlights the molecular complexity of jumbo phages [PDF]

, 2020
Pseudomonas virus vB_PaeM_PA5oct is proposed as a model jumbo bacteriophage to investigate phage-bacteria interactions and is a candidate for phage therapy applications.
Blasdel, Bob G., Briers, Yves, Danis‐Wlodarczyk, Katarzyna, Drulis‐Kawa, Zuzanna, Jang, Ho Bin, Lavigne, Rob, Lood, Cédric, Noben, Jean‐Paul, Noort, Vera, Vandenheuvel, Dieter   +9 more
core   +1 more source

Isolation and characterization of Septuagintavirus; a novel clade of Escherichia coli phages within the subfamily Vequintavirinae

Microbiology Spectrum
Escherichia coli is a commensal inhabitant of the mammalian gut microbiota, frequently associated with various gastrointestinal diseases. There is increasing interest in comprehending the variety of bacteriophages (phages) that target this bacterium, as ...
Adrián Cortés-Martín, Colin Buttimer, Nadiia Pozhydaieva, Frank Hille, Hiba Shareefdeen, Andrei S. Bolocan, Lorraine A. Draper, Andrey N. Shkoporov, Charles M. A. P. Franz, Katharina Höfer, R. Paul Ross, Colin Hill   +11 more
doaj   +1 more source

Identifying Phage Virion Proteins by Using Two-Step Feature Selection Methods

Molecules, 2018
Accurate identification of phage virion protein is not only a key step for understanding the function of the phage virion protein but also helpful for further understanding the lysis mechanism of the bacterial cell. Since traditional experimental methods
Jiu-Xin Tan, Fu-Ying Dao, Hao Lv, Peng-Mian Feng, Hui Ding   +4 more
doaj   +1 more source

Dynamic Cap‐Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease

Advanced Science, EarlyView.
The first crystal structure of MPXV I7L protease, revealing its unique dimeric form is resolved. The structures and MD simulations uncovered a dynamic cap region that regulates substrate access to the active site. The structural basis of substrate recognition and the catalytic mechanism are elucidated, which led to the development of a FRET‐based assay
Haixia Su, Guoqing Wu, Muya Xiong, Yuhang Wang, Junyuan Cao, Mengyuan You, Yingchun Xiang, Tianqing Nie, Minjun Li, Gengfu Xiao, Leike Zhang, Qiang Shao, Yechun Xu   +12 more
wiley   +1 more source

Viral Genome Segmentation Can Result from a Trade-Off between Genetic Content and Particle Stability [PDF]

, 2011
The evolutionary benefit of viral genome segmentation is a classical, yet unsolved question in evolutionary biology and RNA genetics. Theoretical studies anticipated that replication of shorter RNA segments could provide a replicative advantage over ...
Arias, Armando, Domingo, Esteban, Escarmís, Cristina, Garcia Mateu, Mauricio, García-Arriaza, Juan, Manrubia, Susanna C., Ojosnegros, Samuel, Perales, Celia   +7 more
core   +3 more sources

Centrifugation-Based Purification Protocol Optimization Enhances Structural Preservation of Nucleopolyhedrovirus Budded Virion Envelopes

Insects
The structural integrity of viral envelopes is a critical determinant of infectivity for enveloped viruses, directly influencing vector stability, functional accuracy of surface-displayed epitopes, and preservation of native conformational states ...
Yong Pan, Jiming Yan, Yinong Zhang, Jiasheng Lin, Zhiquan Liang, Jingchen Sun   +5 more
doaj   +1 more source

Influenza A Virus Hemagglutinin is Required for the Assembly of Viral Components Including Bundled vRNPs at the Lipid Raft

Viruses, 2016
The influenza glycoproteins, hemagglutinin (HA) and neuraminidase (NA), which are associated with the lipid raft, have the potential to initiate virion budding. However, the role of these viral proteins in infectious virion assembly is still unclear.
Naoki Takizawa, Fumitaka Momose, Yuko Morikawa, Akio Nomoto   +3 more
doaj   +1 more source

Potent Cross‐neutralizing Antibodies Reveal Vulnerabilities of Henipavirus Fusion Glycoprotein

Advanced Science, EarlyView.
Hendra and Nipah viruses (HNVs) pose significant threats to global health. This work reports potent cross‐neutralizing antibodies targeting the fusion glycoprotein (F) and reveals shared features of these antibodies and vulnerabilities of F, thereby guiding the rational design of countermeasures against HNVs and similar pathogens.
Yi Ren, Pengfei Fan, Xinghai Zhang, Ting Fang, Zhengshan Chen, Yanfeng Yao, Xiangyang Chi, Guanying Zhang, Xiaofan Zhao, Bingjie Sun, Fangxu Li, Zixuan Liu, Zhenwei Song, Baoyue Zhang, Cheng Peng, Entao Li, Yilong Yang, Jianmin Li, Sandra Chiu, Changming Yu   +19 more
wiley   +1 more source