Results 131 to 140 of about 22,731 (252)

Immunovirological treatment out- comes after 2 years of antiretroviral therapy in children living with the human immune deficiency virus in Lagos Nigeria

open access: yesNigerian Journal of Paediatrics
Background/objective: The World Health Organization (WHO) recommends routine assessment of antiretroviral treatment outcomes to detect treatment failure early and prevent the development of drug resistance. The aim of this study was to describe treatment
Nwaiwu O   +3 more
doaj  

Mapping the Conformational Landscape of DNA Minicircles Through Atomic Force Microscopy and Shape Space Analysis

open access: yesSmall, EarlyView.
An automated framework is presented for quantifying DNA conformational variability from atomic force microscopy (AFM) images. DNA backbones are reduced to spline representations and analyzed using cyclic Procrustes analysis to measure shape similarity across ensembles.
Laura Wiggins   +7 more
wiley   +1 more source

Large‐Scale Structural Dynamics in the Tail Fiber Modulate the Infective Transition of the T7 Bacteriophage

open access: yesSmall, EarlyView.
During host recognition, the fibers of T7 bacteriophages transition from a capsid bound state to an extended conformation, which requires some level of fiber flexibility. By using high‐speed atomic force microscopy, we show that the fibers have an internal molecular hinge and a torsionally compliant coiled‐coil region.
Luca Elizabet Kosik   +16 more
wiley   +1 more source

Assessment of Oxidative Stress, Vitellogenin, and Human Health Risks Derived From Nile Tilapia Exposed to Metals and Metalloids in Southeastern Brazil

open access: yesEnvironmental Toxicology, EarlyView.
ABSTRACT Urban coastal lagoons are highly vulnerable ecosystems increasingly affected by metal contamination, as well as multiple anthropogenic stressors. This study evaluated ecotoxicological and human health risks associated with chronic metal exposure in Nile tilapia (Oreochromis niloticus) from an anthropogenically impacted lagoon in southeastern ...
Julia Araújo Alves   +8 more
wiley   +1 more source

rDNAmine: A New Tool for the Analysis of Long Repetitive Sequences

open access: yesYeast, EarlyView.
This work introduces a novel approach for analysing long repetitive genomic sequences, combining a method to isolate large DNA molecules from individual chromosomes. We also describe the bioinformatics tool rDNAmine, which enables the isolation of long‐repeat sequences from reads obtained using the Oxford Nanopore method, as well as their preliminary ...
Agnieszka Czarnocka‐Cieciura   +1 more
wiley   +1 more source

Field performance and cost-effectiveness of a point-of-care triage test for HIV virological failure in Southern Africa. [PDF]

open access: yesJ Int AIDS Soc, 2023
Saura-Lázaro A   +14 more
europepmc   +1 more source

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