Results 131 to 140 of about 45,169 (292)

Pharmacy refill adherence outperforms self-reported methods in predicting HIV therapy outcome in resource-limited settings [PDF]

, 2014
BACKGROUND: Optimal adherence to antiretroviral therapy is critical to prevent HIV drug resistance (HIVDR) epidemic. The objective of the study was to investigate the best performing adherence assessment method for predicting virological failure in ...
Anne-Mieke Vandamme, Eligius F Lyamuya, Eric Van Wijngaerden, Fausta Mosha, Jurgen Vercauteren, Mattia Prosperi, Raphael Z Sangeda, Ricardo J Camacho, Said Aboud   +8 more
core   +1 more source

Predictors of virological treatment failure among adult HIV patients on first-line antiretroviral therapy in Woldia and Dessie hospitals, Northeast Ethiopia: a case-control study

BMC Infectious Diseases, 2019
Background Virological treatment failure is a problem that a Human Immune Virus patient faces after starting treatment due to different factors. However, there were few studies done on the predictors of virological treatment failure among adult patients ...
Mohammed Ahmed, Hailu Merga, Habtemu Jarso   +2 more
doaj   +1 more source

Impact of HIV-1 Reverse Transcriptase Polymorphism F214L on Virological Response to Thymidine Analogue—Based Regimens in Antiretroviral Therapy (ART)—Naive and ART-Experienced Patients [PDF]

, 2017
Background.#160;A negative association between the polymorphism F214L and type 1 thymidine analogue (TA) mutations (TAMs) has been observed. However, the virological response to TAs according to the detection of F214L has not been evaluated.
Ceccherini-Silberstein, Francesca, Clotet, Bonaventura, Cozzi-Lepri, Alessandro, Gatell, Jose M., Günthard, Huldrych F., Lundgren, Jens D., Mocroft, Amanda, Olsen, Christian Holkmann, Perno, Carlo Federico, Phillips, Andrew N., Reiss, Peter, Ruiz, Lidia   +11 more
core  

"I take my pills every day, but then it goes up, goes down. I don't know what's going on": Perceptions of HIV virological failure in a rural context in Mozambique. A qualitative research study.

PLoS ONE, 2019
BackgroundHIV prevalence in Mozambique is estimated to be 13.2%. Routine viral load for HIV monitoring was first implemented in the rural area of Tete in 2014.
Ivan Alejandro Pulido Tarquino, Emilie Venables, Jose Manuel de Amaral Fidelis, Ruggero Giuliani, Tom Decroo   +4 more
doaj   +1 more source

SPARK: A webserver for comprehensive search and analysis of testicular single‐cell transcriptomic data covering full lifecycle and pathology

iMetaOmics, EarlyView.
SPARK is an interactive platform hosting 189,232 human testicular single‐cell transcriptomes across normal and infertile conditions. It enables automated, code‐free analysis and visualization, providing a powerful resource to explore cellular and molecular dynamics in male reproduction and infertility.
Lina Cui, Xiaojian Lu, Hui Cai, Ziyan Zhuang, Yifei Guo, Qiaoling Jiang, Zhe Zhang, Hui Jiang, Xiaoyan Wang, Jingtao Guo   +9 more
wiley   +1 more source

Low level of virological failure and drug resistance among patients receiving antiretroviral treatment under programme conditions in Maputo, Mozambique [PDF]

, 2008
Mexico AIDS Conference ...
Anapenge, M, Arendt, V, Bastos, R, Biot, M, Chuquela, H C, Maldonado, F, Masquelier, C, Roman, F, Schmit, J C, Zachariah, R   +9 more
core   +1 more source

HIV-1 subtype-specific drug resistance on dolutegravir-based antiretroviral therapy: protocol for a multicentre study (DTG RESIST)

BMJ Open
Introduction HIV drug resistance poses a challenge to the United Nation’s goal of ending the HIV/AIDS epidemic. The integrase strand transfer inhibitor (InSTI) dolutegravir, which has a higher resistance barrier, was endorsed by the WHO in 2019 for first-
Stefanie Hossmann, Antoine Jaquet, Matthias Egger, Richard Lessells, Jeremy Ross, Mamatha Sauermann, Tom Loosli, Selma Riedo, Niko Beerenwinkel, Albert Minga, Jennifer Giandhari, Roger D Kouyos   +11 more
doaj   +1 more source

Metabolomic and lipidomic signatures of Helicobacter pylori infection: Unveiling biochemical pathways associated with neurodegeneration

iMetaOmics, EarlyView.
Our study employed an integrated lipidomics and metabolomics approach to elucidate Helicobacter pylori‐driven metabolic perturbations along the gut–brain axis. H. pylori infection was established in gastric epithelial (AGS) cells, and the resulting conditioned media (secretome) was collected and exposed to neuronal (IMR‐32) cells.
Meenakshi Kandpal, Tarun Prakash Verma, Siddharth Singh, Hamendra Parmar, Hem Chandra Jha   +4 more
wiley   +1 more source

Progress of metabolomics‐centric multi‐omics research in medicine

iMetaOmics, EarlyView.
The graphical abstract illustrates a holistic roadmap for metabolomics‐centric multi‐omics integration in medical research. The upper panel depicts the technological transition from traditional bulk analysis to high‐resolution single‐cell and spatial methodologies, specifically addressing inherent challenges such as molecular complexity and dynamic ...
Ziyi Wang, Shiwen Deng, Xiaoxu Wang, Xiao Chang, Na Guo, Peng Chen, Hongjun Yang   +6 more
wiley   +1 more source

Predictors of Virological Failure after Adherence-Enhancement Counseling among First-Line Adults Living with HIV/AIDS in Kombolcha Town, Northeast Ethiopia

HIV/AIDS: Research and Palliative Care, 2021
Getachew Bisetegn,1 Mastewal Arefaynie,2 Anissa Mohammed,3 Zinabu Fentaw,3 Amare Muche,3 Reta Dewau,3 Yimer Seid1 1Dessie City Zonal Health Department, CDC-Ethiopia, Dessie, Ethiopia; 2Department of Reproductive and Family Health, School of Public Health,
Bisetegn G, Arefaynie M, Mohammed A, Fentaw Z, Muche A, Dewau R, Seid Y   +6 more
doaj