Results 141 to 150 of about 3,105,782 (329)

Pharmacy refill adherence outperforms self-reported methods in predicting HIV therapy outcome in resource-limited settings [PDF]

, 2014
BACKGROUND: Optimal adherence to antiretroviral therapy is critical to prevent HIV drug resistance (HIVDR) epidemic. The objective of the study was to investigate the best performing adherence assessment method for predicting virological failure in ...
Anne-Mieke Vandamme, Eligius F Lyamuya, Eric Van Wijngaerden, Fausta Mosha, Jurgen Vercauteren, Mattia Prosperi, Raphael Z Sangeda, Ricardo J Camacho, Said Aboud   +8 more
core   +1 more source

In Vitro Live Cell Imaging Reveals Nuclear Dynamics and Role of the Cytoskeleton During Asymmetric Division of Pollen Mitosis I in Nicotiana Benthamiana

Cytoskeleton, EarlyView.
ABSTRACT Pollen is a male gametophyte of angiosperms. Following meiosis, the microspore undergoes an asymmetric division called pollen mitosis I (PMI), which produces two cells of different sizes: a large vegetative cell and a small generative cell. Polarized nuclear migration and positioning during PMI are important for successful pollen development ...
Yoko Mizuta, Masako Igarashi, Tomomi Shinagawa, Ikuma Kaneshiro, Haoto Anan, Daisuke Kurihara   +5 more
wiley   +1 more source

PREVALENCE AND RISK FACTORS OF VIROLOGICAL FAILURE AMONG CHILDREN ON ANTIRETROVIRAL THERAPY

BMJ Global Health, 2017
Background An unprecedented global effort at scaling up universal access to antiretroviral therapy has decreased the progression of HIV. However, due to challenges with supplies and adherence to intermittent antiretroviral therapy (ART) for mothers ...
M. Owusu, Eric Mensah, A. Enimil, M. Mutocheluh   +3 more
semanticscholar   +1 more source

Virological failure to raltegravir in Spain: incidence, prevalence and clinical consequences

Journal of Antimicrobial Chemotherapy, 2015
The objective of this study was to evaluate the incidence, prevalence and clinical consequences of virological failure (VF) to raltegravir-based regimens in Spain.A multicentre, retrospective, observational study was performed in 10 tertiary hospitals (January 2006 to June 2013).
Santos, José R., Blanco, José Luis, Masiá, Mar, Gutiérrez, Félix, Pérez-Elías, María Jesús, Iribarren, José Antonio, Force, Lluis, Antela, Antonio, Knobel, Hernando, Salavert, Miquel, López Bernaldo de Quirós, Juan Carlos, Pino, Maria, Paredes, Roger, Clotet, Bonaventura   +13 more
openaire   +6 more sources

Viral suppression in adolescents on antiretroviral treatment: review of the literature and critical appraisal of methodological challenges. [PDF]

, 2016
OBJECTIVE: Medication adherence is often suboptimal for adolescents with HIV, and establishing correct weight-based antiretroviral therapy dosing is difficult, contributing to virological failure.
Armstrong, Alice, Briggs, Datonye, Ferguson, Jane, Ferrand, Rashida A, Kranzer, Katharina, MacPherson, Peter, Penazzato, Martina, Ross, David A   +7 more
core   +2 more sources

Cardiovascular‐Kidney‐Metabolic Syndrome in People With HIV: An Emerging Frontier for Clinical Pharmacology

Clinical Pharmacology &Therapeutics, EarlyView.
As antiretroviral therapy (ART) prolongs lifespans, people with HIV (PWH) face a new syndemic: Cardiovascular‐Kidney‐Metabolic (CKM) syndrome. Yet CKM in PWH is poorly characterized. Inflammation, complex pharmacokinetic (PK) alterations, ART‐associated metabolic effects, and gut dysbiosis amplify risk. Managing CKM increases medication burden, thereby
Aaron S. Devanathan, Thomas D. Nolin
wiley   +1 more source

Accelerating Generic Long‐Acting Antiretrovirals for Global HIV Treatment: Workshop Findings and a Roadmap to Access

Clinical Pharmacology &Therapeutics, EarlyView.
The global HIV response aims for widespread availability of affordable, quality‐assured long‐acting antiretroviral (LA ARV) drugs to achieve sustained epidemic control, particularly in low‐ and middle‐income countries. This report summarizes key discussion points, findings, and outcomes from an international workshop on generic LA ARVs, held in ...
Usman Arshad, Lobna Gaayeb, Henry Pertinez, Rajith K. R. Rajoli, Melynda Watkins, Parag Nimbolkar, Simone Perazzolo, Bharat Pagi, Annemarie Wensing, Saye Khoo, Marta Boffito, René Holm, Zack Panos, Imelda Mahaka, Francois Venter, Benny Kottiri, Keith W. Crawford, Rodney J. Y. Ho, Polly Clayden, Paul Domanico, Kimberly Struble, Andrew Owen, Charles Flexner   +22 more
wiley   +1 more source

Clinical Pharmacology Quality Assurance Program for Global HIV and Co‐Infection Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
When the acquired immunodeficiency syndrome emerged in the 1980s, the United States National Institutes of Health established research networks to conduct clinical trials with the pharmaceutical industry to identify effective antiretroviral therapeutics.
Robin DiFrancesco, Troy D. Wood, Raymond Cha, Jill S. Hochreiter, Susan L. Rosenkranz, Mona Farhad, Kyle R. Whitson, Connor E. Gould, Lauren E. Hill, Linda L. Hale, Philip H. Lindhorst, Diala Ghazal, Charlene R. Taylor, Madiha Quraishi, Suzanne M. Siminski, Yoninah Cramer, Heather L. Sprenger, Gene D. Morse   +17 more
wiley   +1 more source

Directly observed antiretroviral therapy: a systematic review and meta-analysis of randomised clinical trials. [PDF]

, 2009
BACKGROUND: Directly observed therapy has been recommended to improve adherence for patients with HIV infection who are on highly active antiretroviral therapy, but the benefit and cost-effectiveness of this approach has not been established conclusively.
Altice, Bayer, Berlin, Bussmann, Detsky, Edward J Mills, Farmer, Fleiss, Gross, Gross, Harrigan, Hedges, Hogg, Hozo, Jean B Nachega, Liechty, Lucas, Macalino, Maher, Mark E Engel, Maru, Maru, Maskew, Meade, Mills, Nachega, Nathan Ford, Osterberg, Page-Shipp, Pearson, Pearson, Pogue, Rigsby, Robert, Sackett, Sarna, Sherer, Simoni, Tam, Verma, Volmink, Wohl   +41 more
core   +3 more sources

"I take my pills every day, but then it goes up, goes down. I don't know what's going on": Perceptions of HIV virological failure in a rural context in Mozambique. A qualitative research study.

PLoS ONE, 2019
BackgroundHIV prevalence in Mozambique is estimated to be 13.2%. Routine viral load for HIV monitoring was first implemented in the rural area of Tete in 2014.
Ivan Alejandro Pulido Tarquino, Emilie Venables, Jose Manuel de Amaral Fidelis, Ruggero Giuliani, Tom Decroo   +4 more
doaj   +1 more source