Results 41 to 50 of about 3,105,782 (329)

HIV Treatment Adherence, Drug Resistance, Virologic Failure: Evolving Concepts [PDF]

Infectious Disorders - Drug Targets, 2011
Poor adherence to combined antiretroviral therapy (cART) has been shown to be a major determinant of virologic failure, emergence of drug resistant virus, disease progression, hospitalizations, mortality, and health care costs. While high adherence levels can be achieved in both resource-rich and resource-limited settings following initiation of cART ...
Nachega J.B., Marconi V.C., van Zyl G.U., Gardner E.M., Preiser W., Hong S.Y., Mills E.J., Gross R.   +7 more
openaire   +2 more sources

Virological failure of patients on maraviroc-based antiretroviral therapy [PDF]

Journal of Antimicrobial Chemotherapy, 2015
Abstract Objectives Virological failure (VF) in patients on maraviroc-based treatment has been associated with altered HIV tropism and resistance to maraviroc. This multicentre study aimed to characterize VF in patients treated with maraviroc. Methods
Stéphanie Raymond, Anne Maillard, Corinne Amiel, Gilles Peytavin, Mary Anne Trabaud, Delphine Desbois, Pantxika Bellecave, Constance Delaugerre, Cathia Soulie, Anne Geneviève Marcelin, Diane Descamps, Jacques Izopet, S. Reigadas, P. Bellecave, P. Pinson-Recordon, H. Fleury, B. Masquelier, A. Signori-Schmuck, P. Morand, L. Bocket, L. Mouna, P. André, J. C. Tardy, M. A. Trabaud, D. Descamps, C. Charpentier, G. Peytavin, F. Brun-Vézinet, S. Haim-Boukobza, A. M. Roques, C. Soulié, S. Lambert-Niclot, I. Malet, M. Wirden, S. Fourati, A. G. Marcelin, V. Calvez, P. Flandre, L. Assoumou, D. Costagliola, L. Morand-Joubert, C. Delaugerre, V. Schneider, C. Amiel, G. Giraudeau, A. Maillard, F. Nicot, J. Izopet   +47 more
openaire   +3 more sources

Diagnosis and management of antiretroviral-therapy failure in resource-limited settings in sub-Saharan Africa: challenges and perspectives. [PDF]

, 2010
Despite the enormous progress made in scaling up antiretroviral therapy (ART) in sub-Saharan Africa, many challenges remain, not least of which are the identification and management of patients who have failed first-line therapy. Less than 3% of patients
Akileswaran, Andreas Jahn, Anthony D Harries, Badri, Bierman, Boulle, Boulle, Colebunders, Elliott, Erik J Schouten, Ferradini, Gazzard, Gupta, Hammer, Harries, Harries, Hosseinipour, Joep J van Oosterhout, Johannessen, Johnson, Kamya, Kantor, Keiser, Kelita Kamoto, Kitahata, Kouanfack, Kuhn, Lawn, Lawn, Ledergerber, Libamba, Lockman, Maldonado, Mee, Mills, Mina C Hosseinipour, Moore, Mwaba, Orrell, Phillips, Pujades-Rodriguez, Reynolds, Rony Zachariah, Samb, Sawe, Steven D Reid, Swindells, Tuboi, Uy, van Oosterhout, Vic Arendt, Walmsley, Weiser, Wester, Wilson, Yu, Zachariah, Zengani Chirwa   +57 more
core   +2 more sources

The virological durability of first-line ART among HIV-positive adult patients in resource limited settings without virological monitoring: a retrospective analysis of DART trial data [PDF]

, 2017
BACKGROUND: Few low-income countries have virological monitoring widely available. We estimated the virological durability of first-line antiretroviral therapy (ART) after five years of follow-up among adult Ugandan and Zimbabwean patients in the DART ...
Chirara, M, DART Virology Group, ., Dolling, DI, Dunn, DT, Eram, D, Gilks, CF, Goodall, RL, Hakim, J, Kaleebu, P, Munderi, P, Nkurunziza, P, Pillay, D, Spyer, MJ, Tumukunde, D   +13 more
core   +6 more sources

Effect of a differentiated service delivery model on virological failure in adolescents with HIV in Zimbabwe (Zvandiri): a cluster-randomised controlled trial.

Lancet Global Health, 2020
BACKGROUND Adolescents living with HIV face challenges to their wellbeing and antiretroviral therapy adherence and have poor treatment outcomes. We aimed to evaluate a peer-led differentiated service delivery intervention on HIV clinical and psychosocial
W. Mavhu, Nicola Willis, J. Mufuka, S. Bernays, M. Tshuma, C. Mangenah, H. Maheswaran, W. Mangezi, T. Apollo, R. Araya, H. Weiss, F. Cowan   +11 more
semanticscholar   +1 more source

Challenges and Opportunities for the Implementation of Virological Testing in resource-limited settings [PDF]

, 2012
Though the advantages of routine virological monitoring for patients on anti-retroviral therapy have been established, cost and complexity limit its full implementation.
Bartlett, Department of Health and Human Services, Emmanuel Fajardo, Hamers, Hamers, Helen Bygrave, Jani, Kerschberger, Laurent, Murtagh, Médecins Sans Frontières, Médecins Sans Frontières, Nathan Ford, Orrell, Orrell, Orrell, Oyomopito, Teri Roberts, UNAIDS, Médecins Sans Frontières, World Health Organization, World Health Organization, World Health Organization, World Health Organization, UNAIDS   +22 more
core   +3 more sources

Virological failure, HIV-1 drug resistance, and early mortality in adults admitted to hospital in Malawi: an observational cohort study

The Lancet HIV, 2020
Summary Background Antiretroviral therapy (ART) scale-up in sub-Saharan Africa combined with weak routine virological monitoring has driven increasing HIV drug resistance.
A. Gupta-Wright, K. Fielding, J. V. van Oosterhout, Melanie Alufandika, D. Grint, E. Chimbayo, J. Heaney, M. Byott, E. Nastouli, H. Mwandumba, E. Corbett, Ravindra K. Gupta   +11 more
semanticscholar   +1 more source

Detecting virological failure in HIV-infected Tanzanian children

South African Medical Journal, 2014
The performance of clinical and immunological criteria to predict virological failure in HIV-infected children receiving antiretroviral therapy (ART) is not well documented.To determine the validity of clinical and immunological monitoring in detecting virological failure in children on ART.A total of 218 children were included in the study.
Mgelea, E M, Kisenge, R, Aboud, S
openaire   +5 more sources

Determinants of virological failure among adults on first-line highly active antiretroviral therapy at public health facilities in Kombolcha town, Northeast, Ethiopia: a case–control study

BMJ Open, 2020
Objective To identify determinants of virological failure among HIV-infected adults on first-line highly active antiretroviral therapy at public health facilities in Kombolcha town, Northeast, Ethiopia, in 2019.
Habtamu Mengist Meshesha, Z. Nigussie, Anemaw Asrat, Kebadnew Mulatu   +3 more
semanticscholar   +1 more source

Effectiveness of dolutegravir-based regimens as either first-line or switch antiretroviral therapy: data from the Icona cohort [PDF]

, 2019
Introduction: Concerns about dolutegravir (DTG) tolerability in the real-life setting have recently arisen. We aimed to estimate the risk of treatment discontinuation and virological failure of DTG-based regimens from a large cohort of HIV-infected ...
Abeli C., Acinapura R., alungo A., Andreoni M., Angarano G., Antinori A., aracino A., atini A., azzarin A., Bagella P., Bai F., Baldelli F., Baldin G., Balotta C., Bandera A., Barocci V., Bassetti M., Blanc P., Bobbio N., Bonfanti P., Bonora S., Borderi M., Borgia G., Cacopardo B., Calcagno A., Capetti A., Capobianchi M. R., Capozzi M., Caramello P., Carletti F., Carrara S., Cascio A., Cassola G., Castagna A., Castelli F., Castelnuovo F., Cattelan A. M., Cauda R., Ceccherini-Silberstein F., Ceccherini-Silberstein F., Cecchetto M., Celesia B., Chiodera A., Cicalini S., Cingolani A., Cinque P., Colomba C., Costantini A., Cozzi-Lepri A., Cozzi-Lepri A., Cristaudo A., d'Arminio Monforte A., De Luca A., Di Biagio A., Di Caro A., Di Giuli C., Di Martino F., Di Perri G., Esposito V., Fabrizio C., Falasca K., Fanti I., Fontana Del Vecchio R., Francisci D., Galli L., Galli M., Gentile I., Giacometti I. A., Gianotti N., Girardi E., Gori A., Graziano S., Guaraldi G., i V., Iaiani G., Iardino R., Ippolito G., Lapadula G., lessandrini A., Lichtner M., Lo Caputo S., Lorenzini P., Lorenzotti S., Macchia M., Maddaloni L., Madeddu G., Maggiolo F., Maggiolo F., Magnani G., Manfrin V., Marchetti G., Marinello S., Mastrorosa I., Mazzarello G., Menzaghi B., Migliorino C., Milini P., Minardi C., Moioli M. C., Molteni C., Mondi A., Monno L., Mussini C., Nozza S., Nunnari G., ondero A., Orofino G. C., Pan A., Parruti G., Pellicano G., Pellizzer G., Perno C. F., Petrone F., Piolini R., Plazzi M. M., Pozzetto I., Prota G., Puoti M., Puzzolante C., Quartu S., Quiros Roldan E., Rezza G., Ridolfo A. L., Rivano Capparucia M., Rizzardini G., Rodano' A., Rossetti B., Rossotti R., Rusconi S., Rusconi S., Salpietro S., Sangiovanni V., Santoro M. M., Sarmati L., Savinelli S., Schiaroli E., Sciandra M., Segala D., Sighinolfi L., Sozio F., Starnini G., Suardi C., Tavelli A., Tavelli A., Tincati C., Truffa S., Ursitti M. A., Vecchiet J., Vergori A., Verucchi G., Viale P., Vichi F., Viscoli C., Viviani F., von Schloesser F., Vullo V.   +155 more
core   +4 more sources