Results 121 to 130 of about 437,772 (353)

A method for facile production of variable lymphocyte receptors using SHuffle Escherichia coli

open access: yesBiotechnology Progress, EarlyView.
Abstract Variable lymphocyte receptors (VLRs) are the antigen receptors of jawless vertebrates such as lamprey. VLRs are of growing biotechnological interest for their ability to bind certain antigenic targets with higher affinity than traditional immunoglobulins.
Elizabeth A. Appelt   +9 more
wiley   +1 more source

Tissue‐resident CD69+CXCR6+ Natural Killer cells with exhausted phenotype accumulate in human non‐small cell lung cancer

open access: yesEuropean Journal of Immunology, Volume 52, Issue 12, Page 1993-2005, December 2022., 2022
This study identified a CD69+CXCR6+ tissue‐resident NK (trNK) subset specifically accumulated in the tumor microenvironment of human non‐small cell lung cancer patients. CD69+CXCR6+ trNK cells showed an immunomodulatory‐like and exhaustion phenotype, and secreted IFN‐γ and TNF‐α rapidly. Abstract Natural killer (NK) cells with tissue‐residency features
Xiaoke Chen   +10 more
wiley   +1 more source

The dictionary of virology [PDF]

open access: yesThe Lancet Infectious Diseases, 2009
Recently we have witnessed an explosion in virus discovery. The highest profi le of these “new” viruses is the severe acute respiratory syndrome coronavirus, which made its debut in 2001 with an alarming pandemic that infected 8000 people around the world and claimed 800 victims before it was brought under control.
openaire   +2 more sources

Pre‐folding purification procedures for inclusion body‐derived non‐tagged cationic recombinant proteins with multiple disulfide bonds for efficient refolding

open access: yesBiotechnology Progress, EarlyView.
Abstract The production of disulfide‐containing recombinant proteins often requires refolding of inclusion bodies before purification. A pre‐refolding purification step is crucial for effective refolding because impurities in the inclusion bodies interfere with refolding and subsequent purification.
Shuichiro Kimura   +4 more
wiley   +1 more source

Flt3L, LIF, and IL‐10 combination promotes the selective in vitro development of ESAMlow cDC2B from murine bone marrow

open access: yesEuropean Journal of Immunology, Volume 52, Issue 12, Page 1946-1960, December 2022., 2022
In vitro culture of murine bone marrow cells in Flt3L + LIF + IL‐10 promotes CD11b+ ESAMlow cDC2B subset generation from CDP but blocks cDC1 and pDC development. Flt3L alone or combined does not induce cDC2A generation in vitro. Abstract The development of two conventional dendritic cells (DC) subsets (cDC1 and cDC2) and the plasmacytoid DC (pDC) in ...
Laura Cyran   +8 more
wiley   +1 more source

Creating E.coli Library of Diagnostic Gene for Influenza B Virus Using Molecular Cloning Technique [PDF]

open access: yes, 2014
Influenza viruses cause seasonal epidemics associated with high morbidity, especially in immunocompromised and extreme age group individuals. Many strategies for combating these viruses are in practice; however, developing and maintaining sensitive ...
Chinbat, Oyunsuvd
core  

A design space for the filtration of challenging monoclonal antibodies using Planova™ S20N, a new regenerated cellulose virus removal filter

open access: yesBiotechnology Progress, EarlyView.
Abstract Virus removal by filtration is a crucial step in ensuring the safety of therapeutic antibodies and other biopharmaceutical products by mitigating the risk of endogenous and adventitious viral contamination. However, there are monoclonal antibodies (mAb) that are difficult to filter effectively using virus removal filters (i.e., challenging ...
Asami Inoue   +4 more
wiley   +1 more source

Targeting B cells and plasma cells in autoimmune diseases: From established treatments to novel therapeutic approaches

open access: yesEuropean Journal of Immunology, Volume 53, Issue 1, January 2023., 2023
B lineage cells have been identified as therapeutic targets in autoimmune diseases. In the current review article, we provide an overview of novel strategies to target B lineage cells in autoimmune diseases, with a focus on inflammatory rheumatic diseases.
Ana Merino‐Vico   +3 more
wiley   +1 more source

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