Results 41 to 50 of about 79 (71)

Expanding the Antimicrobial Toolbox with Therapeutic Viruses: Mechanisms, Pharmaceutical Formulation, and Translational Outlook

Pharmaceuticals
Infectious diseases continue to represent one of the most persistent challenges in human health and agricultural productivity. These diseases are caused by a wide range of pathogenic microorganisms, including bacteria, fungi, viruses, and parasites ...
Margarita Strimaite, Holly A. Bailey, Diba Keyhanfar, Roxy Lee, Gareth R. Williams   +4 more
doaj   +1 more source

Genome and Environmental Activity of a Chrysochromulina parva Virus and Its Virophages

Frontiers in Microbiology, 2019
Some giant viruses are ecological agents that are predicted to be involved in the top-down control of single-celled eukaryotic algae populations in aquatic ecosystems.
Joshua M. A. Stough, Natalya Yutin, Yuri V. Chaban, Mohammed Moniruzzaman, Eric R. Gann, Helena L. Pound, Morgan M. Steffen, Jenna N. Black, Eugene V. Koonin, Steven W. Wilhelm, Steven M. Short   +10 more
doaj   +1 more source

Sputnik virophage disrupts the transcriptional regulation of its host giant virus

Journal of Virology
Sputnik virophages are small double-stranded DNA (dsDNA) viruses that replicate only inside host amoebae infected with giant dsDNA viruses, mimiviruses.
Jingjie Chen, Hiroyuki Ogata, Hiroyuki Hikida   +2 more
doaj   +1 more source

Diversity, evolution, and classification of virophages uncovered through global metagenomics

Microbiome, 2019
Background Virophages are small viruses with double-stranded DNA genomes that replicate along with giant viruses and co-infect eukaryotic cells. Due to the paucity of virophage reference genomes, a collective understanding of the global virophage ...
David Paez-Espino, Jinglie Zhou, Simon Roux, Stephen Nayfach, Georgios A. Pavlopoulos, Frederik Schulz, Katherine D. McMahon, David Walsh, Tanja Woyke, Natalia N. Ivanova, Emiley A. Eloe-Fadrosh, Susannah G. Tringe, Nikos C. Kyrpides   +12 more
doaj   +1 more source

Giant virus vs amoeba: fight for supremacy

Virology Journal, 2019
Since the discovery of mimivirus, numerous giant viruses associated with free-living amoebae have been described. The genome of giant viruses can be more than 2.5 megabases, and virus particles can exceed the size of many bacteria.
Graziele Oliveira, Bernard La Scola, Jônatas Abrahão   +2 more
doaj   +1 more source

Conserved tripartite tail proteins mediate virophage-host interactions through Synechococcus lipopolysaccharide binding

Journal of Virology
Virophages are small double-stranded DNA viruses that parasitize giant viruses and play crucial roles in microbial ecosystem dynamics. In this study, we investigate three evolutionarily conserved tail proteins in Dishui Lake Virophage 2 (DSLV2) that ...
Ting Chu, Qinran Wang, Chen Hu, Zexian Zhou, Bo Li, Yesheng Yan, Xiang Li, Aohan Wang, Qianglin Fang, Shuling Yan, Lanming Chen, Yongxin Yu, Yongjie Wang   +12 more
doaj   +1 more source

Role of the R349 Gene and Its Repeats in the MIMIVIRE Defense System

Frontiers in Microbiology, 2019
MIMIVIRE is a defense system described in lineage A Mimivirus (Mimiviridae family) that mediates resistance against Zamilon virophage. It is composed of putative helicase and nuclease associated with a gene of unknown function called R349, which contains
Said Mougari, Jonatas Abrahao, Jonatas Abrahao, Graziele P. Oliveira, Jacques Y. Bou Khalil, Bernard La Scola   +5 more
doaj   +1 more source

Pantanal virophage: a new virophage species associated with a moumouvirus and a transpoviron, expanding the genus Sputnikvirus

Journal of Virology
Amoeba-infecting giant viruses, such as mimiviruses, challenged paradigms of virology since their discovery. Their extensive and complex genomes and particle structures can interact with virophages and transpovirons, revealing unique aspects of the viral
Bruna Luiza de Azevedo, Nidia Esther Colquehuanca Arias, Talita Bastos Machado, João Pessoa Araújo Júnior, Ana Karoline da Nóbrega Nunes Alves, Luiz Carlos Junior Alcantara, Frank O. Aylward, Luiz Henrique Rosa, Rodrigo Araújo Lima Rodrigues, Jônatas Santos Abrahão   +9 more
doaj   +1 more source

Structural and Mechanistic Analyses Reveal a Unique Cas4-like Protein in the Mimivirus Virophage Resistance Element System

iScience, 2018
Summary: A clustered regularly interspaced short palindromic repeats (CRISPR)-like “mimivirus virophage resistance element” (MIMIVIRE) system, which contains specific cascade genes and a CRISPR array against virophages, was reported in mimiviruses.
Chao Dou, Mingjing Yu, Yijun Gu, Jinjing Wang, Kun Yin, Chunlai Nie, Xiaofeng Zhu, Shiqian Qi, Yuquan Wei, Wei Cheng   +9 more
doaj   +1 more source

Biological Trajectory of Virophage Research and the Emergence of Marine Virophages: A Scoping Review

Viruses
Virophages are satellite viruses that depend on the replication machinery of giant double-stranded DNA viruses and influence the structure and dynamics of viral communities through multilayered interactions among giant viruses, their hosts, and ...
Min-Jeong Kim, Yu Jin Kim, Hyun Ju Ha, Joon Sang Park, Ika Agus Rini, Sukchan Lee, Taek-Kyun Lee   +6 more
doaj   +1 more source