Results 71 to 80 of about 6,591 (162)

Biotechnological Interventions for the Production of Subunit Vaccines Against Group A Rotavirus

Cell Biochemistry and Function, Volume 42, Issue 8, December 2024.
ABSTRACT Group A rotavirus (RVA) is a major cause of severe gastroenteritis in infants and young children globally, despite the availability of live‐attenuated vaccines. Challenges such as limited efficacy in low‐income regions, safety concerns for immunocompromised individuals, and cold‐chain dependency necessitate alternative vaccine strategies ...
Mukta Prajapati, Pooja Malik, Astha Sinha, Honey Yadav, Yachna K. Jaiwal, Yogesh K. Ahlawat, Darshna Chaudhary, Ranjana Jaiwal, Nisha Sharma, Pawan K. Jaiwal, Vijay K. Chattu   +10 more
wiley   +1 more source

Transmission Electron Microscopy of Coral Tissue

Current Protocols, Volume 4, Issue 11, November 2024.
Abstract Coral reefs are invaluable ecosystems that are under threat from various anthropogenic stressors. There has been a recent increase in the diagnostic tools utilized to understand how these threats impact coral reef health. Unfortunately, the application of diagnostic tools like transmission electron microscopy (TEM) is not as standardized or ...
Erin Papke, Grace E. Kennedy, Elizabeth Elliott, Alison Taylor, Bradley B. Tolar, Blake Ushijima   +5 more
wiley   +1 more source

Association of rotavirus viroplasms with microtubules through NSP2 and NSP5

Memorias do Instituto Oswaldo Cruz, 2006
Rotavirus replication and virus assembly take place in electrodense spherical structures known as viroplasms whose main components are the viral proteins NSP2 and NSP5.
Claudio Cabral-Romero, Luis Padilla-Noriega   +1 more
doaj   +1 more source

Rotavirus-Mediated DGAT1 Degradation: A Pathophysiological Mechanism of Viral-Induced Malabsorptive Diarrhea [PDF]

, 2023
Gastroenteritis is among the leading causes of mortality globally in infants and young children, with rotavirus (RV) causing ~258 million episodes of diarrhea and ~128,000 deaths annually in infants and children.
Crawford, Sue E, Criglar, Jeanette M, Estes, Mary K, Karandikar, Umesh, Liu, Zheng, Smith, Hunter, Valentin, Antonio J, Zeng, Xi-Lei   +7 more
core   +2 more sources

The C4 photosynthesis bifunctional enzymes, PDRPs, of maize are co‐opted to cytoplasmic viral replication complexes to promote infection of a prevalent potyvirus sugarcane mosaic virus

Plant Biotechnology Journal, Volume 22, Issue 7, Page 1812-1832, July 2024.
Summary In maize, two pyruvate orthophosphate dikinase (PPDK) regulatory proteins, ZmPDRP1 and ZmPDRP2, are respectively specific to the chloroplast of mesophyll cells (MCs) and bundle sheath cells (BSCs). Functionally, ZmPDRP1/2 catalyse both phosphorylation/inactivation and dephosphorylation/activation of ZmPPDK, which is implicated as a major rate ...
Jipeng Xie, Xiaohong Fei, Qin Yan, Tong Jiang, Zhifang Li, Hui Chen, Baichen Wang, Qing Chao, Yueqiu He, Zaifeng Fan, Lijin Wang, Meng Wang, Liang Shi, Tao Zhou   +13 more
wiley   +1 more source

Conserved rotavirus NSP5 and VP2 domains interact and affect viroplasm [PDF]

, 2020
One step of the life cycle common among all rotaviruses (RV) studied so far is the formation of viroplasms, membrane-less cytosolic inclusions providing a microenvironment for early morphogenesis and RNA replication.
Ackermann, Mathias, Buttafuoco, Antonino, Eichwald, Catherine, Fraefel, Cornel, Michaelsen, Kevin, Tobler, Kurt   +5 more
core   +1 more source

Lipid Droplets in Virus Replication

FEBS Letters, Volume 598, Issue 10, Page 1299-1300, May 2024.
Intracellular pathogens rely on host metabolic networks for multiplication. Enveloped viruses need lipids for formation of the viral envelope and positive sense RNA viruses that replicate in membranous inclusions require lipids for formation of the replication compartments.
Eva Herker
wiley   +1 more source

Ultrastructural study on experimental infection of rotavirus in a murine heterologous model

Memorias do Instituto Oswaldo Cruz, 1994
Viral replication, histopathological and ultrastructural changes were observed for a period of nine days in the small intestine of suckling mice infected with a simian rotavirus (SA11).
Selma Majerowicz, Claire Fernandes Kubelka, Paulo Stephens, Ortrud Monika Barth   +3 more
doaj   +1 more source

Experimental pathways towards developing a rotavirus reverse genetics system: synthetic full length rotavirus ssRNAs are neither infectious nor translated in permissive cells. [PDF]

PLoS ONE, 2013
At present the ability to create rationally engineered mutant rotaviruses is limited because of the lack of a tractable helper virus-free reverse genetics system. Using the cell culture adapted bovine RV RF strain (G6P6 [1]), we have attempted to recover
James E Richards, Ulrich Desselberger, Andrew M Lever   +2 more
doaj   +1 more source

Host Factors interacting with the Pestivirus N terminal protease, Npro are Components of the Ribonucleoprotein Complex [PDF]

, 2014
The viral N-terminal protease N(pro) of pestiviruses counteracts cellular antiviral defenses through inhibition of IRF3. Here we used mass spectrometry to identify a new role for N(pro) through its interaction with over 55 associated proteins, mainly ...
A. Donaszi-Ivanov, Anderson, Aratani, Ariumi, Barsnes, Bauhofer, Beckham, Belsham, Bensaude, Borghese, Chatel-Chaix, Chatel-Chaixa, Costa-Mattioli, Cox, Dixit, Doceul, Eisinger-Mathason, Ettema, Fiebach, Fullam, G. Saalbach, Garcia, Gilks, Gorchakov, Haasnoot, Isken, Jefferson, Johns, Kato, Kok, La Rocca, Lawrence, Leung, Li, Liu, Lloyd, M. Jefferson, Meyers, Müller-McNicoll, Netherton, Onishi, P. P. Powell, Panas, Paranjape, Peterhans, Pichlmair, Piotrowska, Robb, Rümenapf, S. Pollen, Sadler, Saunders, Schröder, Szymanski, T. Dalmay, Taylor, Tetsuka, Tetsuka, Tratschin, White, White, Zhang, Zögg   +62 more
core   +1 more source