Rotavirus-Mediated DGAT1 Degradation: A Pathophysiological Mechanism of Viral-Induced Malabsorptive Diarrhea [PDF]
, 2023 Gastroenteritis is among the leading causes of mortality globally in infants and young children, with rotavirus (RV) causing ~258 million episodes of diarrhea and ~128,000 deaths annually in infants and children.
Crawford, Sue E +7 more
core +2 more sources
Deconstructing virus condensation.
PLoS Pathogens, 2021 Viruses have evolved precise mechanisms for using the cellular physiological pathways for their perpetuation. These virus-driven biochemical events must be separated in space and time from those of the host cell.
Nora Lopez +7 more
doaj +1 more source
Forkhead box transcription factor regulation and lipid accumulation by hepatitis C virus [PDF]
, 2014 We have previously shown that hepatitis C virus (HCV) infection modulates the expression of forkhead box transcription factors, including FoxO1 and FoxA2, which play key roles in gluconeogenesis and β-oxidation of fatty acid, respectively. The aim of the
Bose, Sandip K +5 more
core +2 more sources
Virus factories, double membrane vesicles and viroplasm generated in animal cells
Current Opinion in Virology, 2011 Many viruses reorganise cellular membrane compartments and the cytoskeleton to generate subcellular microenvironments called virus factories or 'viroplasm'. These create a platform to concentrate replicase proteins, virus genomes and host proteins required for replication and also protect against antiviral defences.
Netherton, Christopher L, Wileman, Tom
openaire +3 more sources
Rotavirus NSP4 Induces a Novel Vesicular Compartment Regulated by Calcium and Associated with Viroplasms [PDF]
Journal of Virology, 2006 ABSTRACTRotavirus is a major cause of infantile viral gastroenteritis. Rotavirus nonstructural protein 4 (NSP4) has pleiotropic properties and functions in viral morphogenesis as well as pathogenesis. Recent reports show that the inhibition of NSP4 expression by small interfering RNAs leads to alteration of the production and distribution of other ...
Z, Berkova +5 more
openaire +2 more sources
Scientific Opinion on the pest categorisation of Strawberry latent C virus [PDF]
, 2014 The Panel on Plant Health performed a pest categorisation of Strawberry latent C virus (SLCV) for the European Union (EU) territory. SLCV is defined only by symptoms in strawberry indicators.
Baker, Richard +19 more
core +1 more source
Rotavirus NSP5: Mapping Phosphorylation Sites and Kinase Activation and Viroplasm Localization Domains [PDF]
Journal of Virology, 2002 ABSTRACT Rotavirus NSP5 is a nonstructural protein that localizes in cytoplasmic viroplasms of infected cells. NSP5 interacts with NSP2 and undergoes a complex posttranslational hyperphosphorylation, generating species with reduced polyacrylamide gel electrophoresis mobility.
Catherine, Eichwald +3 more
openaire +2 more sources
The cell biology of Tobacco mosaic virus replication and movement [PDF]
, 2013 Successful systemic infection of a plant by Tobacco mosaic virus (TMV) requires three processes that repeat over time: initial establishment and accumulation in invaded cells, intercellular movement and systemic transport.
Chengke Liu, Richard S. Nelson
core +2 more sources
Identification of putative viroplasms within banana cells infected by banana streak MY virus
Journal of General Virology, 2020 The badnavirus replication cycle is poorly understood and most knowledge is based on extrapolations from model viruses such as Cauliflower mosaic virus (CaMV). However, in contrast to CaMV, badnaviruses are thought not to produce viroplasms and therefore it has been a mystery as to where virion assembly occurs.
Thu Ha Ngo +5 more
openaire +3 more sources
The CaMV transactivator/viroplasmin interferes with RDR6-dependent trans-acting and secondary siRNA pathways in Arabidopsis [PDF]
, 2008 Several RNA silencing pathways in plants restrict viral infections and are suppressed by distinct viral proteins. Here we show that the endogenous trans-acting (ta)siRNA pathway, which depends on Dicer-like (DCL) 4 and RNA-dependent RNA polymerase (RDR ...
Padubidri V. Shivaprasad +57 more
core +1 more source