Results 1 to 10 of about 14,083 (192)
Exploiting tumor epigenetics to improve oncolytic virotherapy [PDF]
, 2013 Oncolytic viruses (OVs) comprise a versatile and multi-mechanistic therapeutic platform in the growing arsenal of anticancer biologics. These replicating therapeutics find favorable conditions in the tumor niche, characterized among others by increased ...
Hesham Abdelbary +4 more
core +3 more sources
The 16th international oncolytic virotherapy conference: from in vitro to clinical studies, novel approaches in cancer therapy meeting report [PDF]
Frontiers in ImmunologyThe 16th International Oncolytic Virotherapy Conference, which was held in the vibrant city of Rotterdam, Netherlands, on 27-30th November 2024, featured a variety of novel strategies for improving oncolytic virus therapy.
Elena Ekrami +4 more
doaj +2 more sources
Small Hero with Great Powers: Vaccinia Virus E3 Protein and Evasion of the Type I IFN Response
Biomedicines, 2022 Poxviridae have developed a plethora of strategies to evade innate and adaptive immunity. In this review, we focused on the vaccinia virus E3 protein, encoded by the E3L gene. E3 is present within the Chordopoxvirinae subfamily (with the exception of the
Mateusz Szczerba +5 more
doaj +1 more source
Evaluation of a toxoid fusion protein vaccine produced in plants to protect poultry against necrotic enteritis [PDF]
PeerJ, 2019 Background Necrotic enteritis (NE) is caused by type A strains of the bacterium Clostridium perfringens. Total global economic losses to the poultry industry due to NE is estimated to be over two billion dollars annually.
Joseph G.L. Hunter +7 more
doaj +2 more sources
Oncolytic Measles Virus Encoding MicroRNA for Targeted RNA Interference
Viruses, 2023 Virotherapy is a promising, novel form of cancer immunotherapy currently being investigated in pre-clinical and clinical settings. While generally well-tolerated, the anti-tumor potency of oncolytic virus-based monotherapies needs to be improved further.
Sophie C. Anker +7 more
doaj +1 more source
Oncolytic Virotherapy for Melanoma Brain Metastases, a Potential New Treatment Paradigm?
Brain Sciences, 2021 Introduction: Melanoma brain metastases remain a devastating disease process with poor prognosis. Recently, there has been a surge in studies demonstrating the efficacy of oncolytic virotherapy for brain tumor treatment.
Sauson Soldozy +12 more
doaj +1 more source
Vaccines, 2022 The Omicron SARS-CoV-2 variant has been designated as a variant of concern because its spike protein is heavily mutated. In particular, the Omicron spike is mutated at five positions (K417, N440, E484, Q493, and N501) that have been associated with ...
Karen V. Kibler +9 more
doaj +1 more source
npj Biofilms and Microbiomes, 2021 While sequencing technologies have revolutionized our knowledge of microbial diversity, little is known about the dynamic emergent phenotypes that arise within the context of mixed-species populations, which are not fully predicted using sequencing ...
Jiseon Yang +6 more
doaj +1 more source
Case report: Immunovirotherapy as a novel add-on treatment in a patient with thoracic NUT carcinoma
Frontiers in Oncology, 2022 NUT carcinoma (NC) is a rare and extremely aggressive form of cancer, usually presenting with intrathoracic or neck manifestations in adolescents and young adults.
Linus D. Kloker +25 more
doaj +1 more source
mAbs, 2021 Cancer therapeutics approved for clinical application include oncolytic viruses and antibodies, which evolved by nature, but were improved by molecular engineering.
Roland E. Kontermann +2 more
doaj +1 more source