Results 21 to 30 of about 17,431 (301)

Oncolytic Virotherapy in Glioma Tumors [PDF]

International Journal of Molecular Sciences, 2020
Glioma tumors are one of the most devastating cancer types. Glioblastoma is the most advanced stage with the worst prognosis. Current therapies are still unable to provide an effective cure. Recent advances in oncolytic immunotherapy have generated great expectations in the cancer therapy field. The use of oncolytic viruses (OVs) in cancer treatment is
Angel Ayuso-Sacido, Antonia García, Sergio Rius-Rocabert, Sergio Rius-Rocabert, Estanislao Nistal-Villán, Estanislao Nistal-Villán, Noemí García-Romero   +6 more
openaire   +5 more sources

Oncolytic virotherapy in cancer treatment: challenges and optimization prospects

Frontiers in Immunology, 2023
Oncolytic viruses (OVs) are emerging cancer therapeutics that offer a multifaceted therapeutic platform for the benefits of replicating and lysing tumor cells, being engineered to express transgenes, modulating the tumor microenvironment (TME), and ...
Lingjuan Chen, Mengsi Zuo, Qin Zhou, Yang Wang   +3 more
semanticscholar   +1 more source

Systemic delivery of glycosylated-PEG-masked oncolytic virus enhances targeting of antitumor immuno-virotherapy and modulates T and NK cell infiltration

Theranostics, 2023
Rationale: Immuno-virotherapy has emerged as a promising approach for cancer treatment, as it directly and cytotoxically eliminates tumors with systemic immune stimulation.
Yuzhi Liang, Bing Wang, Qingjing Chen, Xingyue Fu, Chenwei Jiang, Zhiwen Lin, Q. Zhuang, Yongyi Zeng, Xiaolong Liu, Da Zhang   +9 more
semanticscholar   +1 more source

Cytokines in oncolytic virotherapy

Cytokine & Growth Factor Reviews, 2020
Tumors represent a hostile environment for the effector cells of cancer immunosurveillance. Immunosuppressive receptors and soluble or membrane-bound ligands are abundantly exposed and released by malignant entities and their stromal accomplices. As a consequence, executioners of antitumor immunity inefficiently navigate across cancer tissues and fail ...
Pol, Jonathan, Workenhe, Samuel, Konda, Prathyusha, Gujar, Shashi, Kroemer, Guido   +4 more
openaire   +4 more sources

Oncolytic virotherapy evolved into the fourth generation as tumor immunotherapy

Journal of Translational Medicine, 2023
Background Oncolytic virotherapy (OVT) is a promising anti-tumor modality that utilizes oncolytic viruses (OVs) to preferentially attack cancers rather than normal tissues.
Xianwang Wang, Yihua Shen, X. Wan, Xiaoqing Hu, Wen-Qi Cai, Zijun Wu, Qiang Xin, Xiaoqing Liu, Jingang Gui, Hong-Yi Xin, H. Xin   +10 more
semanticscholar   +1 more source

Blockade of innate inflammatory cytokines TNFα, IL-1β, or IL-6 overcomes virotherapy-induced cancer equilibrium to promote tumor regression

Immunotherapy Advances, 2023
Summary Cancer therapeutics can lead to immune equilibrium in which the immune response controls tumor cell expansion without fully eliminating the cancer.
Michael J. Walsh, Lestat R. Ali, P. Lenehan, Courtney T S Kureshi, R. Kureshi, M. Dougan, D. Knipe, S. Dougan   +7 more
semanticscholar   +1 more source

Viral anti‐inflammatory serpin reduces immuno‐coagulopathic pathology in SARS‐CoV‐2 mouse models of infection

EMBO Molecular Medicine, 2023
SARS‐CoV‐2 acute respiratory distress syndrome (ARDS) induces uncontrolled lung inflammation and coagulopathy with high mortality. Anti‐viral drugs and monoclonal antibodies reduce early COVID‐19 severity, but treatments for late‐stage immuno‐thrombotic ...
Liqiang Zhang, Yize Henry Li, Karen Kibler, Simona Kraberger, Arvind Varsani, Julie Turk, Nora Elmadbouly, Emily Aliskevich, Laurel Spaccarelli, Bereket Estifanos, Junior Enow, Isabela Rivabem Zanetti, Nicholas Saldevar, Efrem Lim, Jessika Schlievert, Kyle Browder, Anjali Wilson, Fernando Arcos Juan, Aubrey Pinteric, Aman Garg, Henna Monder, Rohan Saju, Savanah Gisriel, Bertram Jacobs, Timothy L Karr, Esther Borges Florsheim, Vivek Kumar, John Wallen, Masmudur Rahman, Grant McFadden, Brenda G Hogue, Alexandra R Lucas   +31 more
doaj   +1 more source

An Unconventional Case Study of Neoadjuvant Oncolytic Virotherapy for Recurrent Breast Cancer. [PDF]

Vaccines (Basel)
Intratumoural oncolytic virotherapy may have promise as a means to debulk and downstage inoperable tumours in preparation for successful surgery. Here, we describe the unique case of a 50-year-old self-experimenting female virologist with locally ...
Forčić D, Mršić K, Perić-Balja M, Kurtović T, Ramić S, Silovski T, Pedišić I, Milas I, Halassy B.   +8 more
europepmc   +2 more sources

Current Status and Challenges of Oncolytic Virotherapy for the Treatment of Glioblastoma

Pharmaceuticals, 2023
Despite decades of research and numerous clinical trials, the prognosis of patients diagnosed with glioblastoma (GBM) remains dire with median observed survival at 8 months.
M. Webb, U. Sener, R. Vile
semanticscholar   +1 more source

Emerging trends and research foci of oncolytic virotherapy for central nervous system tumors: A bibliometric study

Frontiers in Immunology, 2022
Background Central nervous system tumor (CNST) is one of the most complicated and lethal forms of human tumors with very limited treatment options. In recent years, growing evidence indicates that oncolytic virotherapy (OVT) has emerged as a promising ...
Kunming Cheng, Huan Zhang, Q. Guo, P. Zhai, Yan Zhou, Weiguang Yang, Yulin Wang, Yanqiu Lu, Zefeng Shen, Haiyang Wu   +9 more
semanticscholar   +1 more source