Results 31 to 40 of about 13,459 (185)
Pharmaceutics, 2020 Complex dermal wounds represent major medical and financial burdens, especially in the context of comorbidities such as diabetes, infection and advanced age.
Jordan R. Yaron +10 more
doaj +1 more source
CXCL12 retargeting of an adenovirus vector to cancer cells using a bispecific adapter [PDF]
, 2016 Ad vectors are promising delivery vehicles for cancer therapeutic interventions. However, their application is limited by promiscuous tissue tropism and hepatotoxicity. This limitation can be avoided by altering the native tropism of Ads so that they can
Bhatia, Shilpa +4 more
core +3 more sources
Frontiers in Immunology, 2021 Immune checkpoint inhibitors such as anti-PD-1 have revolutionized the field of oncology over the past decade. Nevertheless, the majority of patients do not benefit from them.
Victor Cervera-Carrascon +21 more
doaj +1 more source
Oncolytic Viruses and the Immune System: The Dynamic Duo
Molecular Therapy: Methods & Clinical Development, 2020 Oncolytic viruses (OVs) constitute a new and promising immunotherapeutic approach toward cancer treatment. This therapy takes advantage of the natural propensity of most tumor cells to be infected by specific OVs.
Ana Lemos de Matos +2 more
doaj +1 more source
Personalizing Oncolytic Virotherapy?
Molecular Therapy, 2007 raditionally, cancer therapies have been based on the empiric discovery of drugs and/or biological agents that act selectively against tumor cells. Recently, however, a generation of rationally discov-ered drugs and agents has been developed that shows encouraging benefi t in treating cancers.
Kaur, Balveen, Chiocca, E Antonio
openaire +2 more sources
Lung cancer and oncolytic virotherapy——enemy's enemy
Translational Oncology, 2023 Lung cancer is one of the malignant tumors that seriously threaten human health worldwide, while the covid-19 virus has become people's nightmare after the coronavirus pandemic. There are too many similarities between cancer cells and viruses, one of the
Zhang Li +3 more
doaj +1 more source
Measles virus causes immunogenic cell death in human melanoma [PDF]
, 2011 Oncolytic viruses (OV) are promising treatments for cancer, with several currently undergoing testing in randomised clinical trials. Measles virus (MV) has not yet been tested in models of human melanoma.
Bond, Jacquelyn +14 more
core +1 more source
Frontiers in Immunology, 2020 Therapeutics based on fusing a protein of interest to the IgG Fc domain have been enormously successful, though fewer studies have investigated the vaccine potential of IgG fusions.
Andrew G. Diamos +13 more
doaj +1 more source
Frontiers in Cardiovascular Medicine, 2021 Diffuse alveolar hemorrhage (DAH) is one of the most serious clinical complications of systemic lupus erythematosus (SLE). The prevalence of DAH is reported to range from 1 to 5%, but while DAH is considered a rare complication there is a reported 50–80%
Qiuyun Guo +13 more
doaj +1 more source
Virotherapy – cancer targeted pharmacology
Drug Discovery Today, 2012 Building on their success in vaccination, many groups are now exploring the use of viruses as anticancer agents. In general, viral therapeutics provide the possibility to express anticancer proteins directly at the tumour site, decreasing exposure to normal tissue during delivery and maximising therapeutic index.
Tedcastle, A +4 more
openaire +3 more sources