Results 41 to 50 of about 11,979 (257)
The Hitchhiker's Guide to Virotherapy
Oncotarget, 2012 In contrast to most other cancer therapies, early research with oncolytic viruses (OV) tended to use direct or intratumoural routes of administration, initially motivated by concerns that the major limitation of intravenous delivery would be immune attack against the viruses, whether by complement, cytokine or most critically neutralising antibodies ...
Alan Melcher +4 more
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Vaccines, 2020 Myxoma virus (MYXV) is the prototypic member of the Leporipoxvirus genus of the Poxviridae family of viruses. In nature, MYXV is highly restricted to leporids and causes a lethal disease called myxomatosis only in European rabbits (Oryctologous cuniculus)
Masmudur M. Rahman, Grant McFadden
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Stochastic Analysis of Nonlinear Cancer Disease Model through Virotherapy and Computational Methods
Mathematics, 2022 Cancer is a common term for many diseases that can affect anybody. A worldwide leading cause of death is cancer, according to the World Health Organization (WHO) report. In 2020, ten million people died from cancer.
A. Raza +4 more
semanticscholar +1 more source
Syncytia Formation in Oncolytic Virotherapy [PDF]
Molecular Therapy - Oncolytics, 2019 Oncolytic virotherapy uses replication-competent virus as a means of treating cancer. Whereas this field has shown great promise as a viable treatment method, the limited spread of these viruses throughout the tumor microenvironment remains a major challenge. To overcome this issue, researchers have begun looking at syncytia formation as a novel method
Eric Bartee, Chase Burton
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Intraarterial delivery of virotherapy for glioblastoma [PDF]
Neurosurgical Focus, 2021 Oncolytic viruses (OVs) have been used in the treatment of cancer, in a focused manner, since the 1990s. These OVs have become popular in the treatment of several cancers but are only now gaining interest in the treatment of glioblastoma (GBM) in recent clinical trials.
Frederick F. Lang +2 more
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Viruses, 2023 Oncolytic virotherapy constitutes a promising treatment option for many solid cancers, including peritoneal carcinomatosis (PC), which still represents a terminal stage of many types of tumors.
Jana Koch +12 more
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Implications of MicroRNAs in Oncolytic Virotherapy [PDF]
Frontiers in Oncology, 2017 MicroRNAs (miRNAs) are an abundant class of small non-coding RNA molecules (~22 nt) that can repress gene expression. Deregulation of certain miRNAs is widely recognized as a robust biomarker for many neoplasms, as well as an important player in tumorigenesis and the establishment of tumoral microenvironments.
Xavier Bofill-De Ros +5 more
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Pharmaceutics, 2020 Complex dermal wounds represent major medical and financial burdens, especially in the context of comorbidities such as diabetes, infection and advanced age.
Jordan R. Yaron +10 more
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Progress of oncolytic virotherapy for neuroblastoma
Frontiers in Pediatrics, 2022 As a neuroendocrine tumor derived from the neural crest, neuroblastoma (NB) is the most common extracranial solid tumor in children. The prognosis in patients with low- and intermediate-risk NB is favorable while that in high-risk patients is often detrimental.
Xiao-Tong Chen +7 more
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Nature Communications, 2022 Immunotherapies directly enhancing anti-tumor CD8^+ T cell responses have yielded measurable but limited success, highlighting the need for alternatives.
J. Svensson-Arvelund +15 more
semanticscholar +1 more source