Results 71 to 80 of about 17,431 (301)

Oncolytic virotherapy for pancreatic cancer [PDF]

Expert Reviews in Molecular Medicine, 2011
Within the past decade, many oncolytic viruses (OVs) have been studied as potential treatments for pancreatic cancer and some of these are currently under clinical trials. The applicability of certain OVs, such as adenoviruses, herpesviruses and reoviruses, for the treatment of pancreatic cancer has been intensively studied for several years, whereas ...
Grant McFadden, Shoudong Li, Sonia Wennier   +2 more
openaire   +3 more sources

Efficient Prodrug Activator Gene Therapy by Retroviral Replicating Vectors Prolongs Survival in an Immune-Competent Intracerebral Glioma Model. [PDF]

, 2020
Prodrug activator gene therapy mediated by murine leukemia virus (MLV)-based retroviral replicating vectors (RRV) was previously shown to be highly effective in killing glioma cells both in culture and in vivo.
Chang, Deching, Chang, Hao-Fang, Chen, Bing-Mao, Chen, Shih-Han, Chen, Thomas C, Collins, Sara, Kasahara, Noriyuki, Lin, Sheng-Che, Lu, Yin-Che, Sun, Jui-Ming, Tai, Chien-Kuo, Wang, Hsin-Ell, Wang, Weijun, Wu, Shu-Fen   +13 more
core   +2 more sources

Oncolytic Virotherapy: A New Paradigm in Cancer Immunotherapy

International Journal of Molecular Sciences
Oncolytic viruses (OVs) are emerging as potential treatment options for cancer. Natural and genetically engineered viruses exhibit various antitumor mechanisms.
S. Volovat, D. Scripcariu, I. Vasilache, C. Stolniceanu, C. Volovăț, I. Augustin, C. Volovăț, Mădălina-Raluca Ostafe, Slevoacă-Grigore Andreea-Voichița, Toni Bejusca-Vieriu, C. Lungulescu, D. Sur, Diana Boboc   +12 more
semanticscholar   +1 more source

The Complex Role of Infectious Agents in Human Cutaneous T-Cell Lymphoma Pathogenesis: From Candidate Etiological Factors to Potential Therapeutics

Pathogens
Cutaneous T-cell lymphoma (CTCL) is a devastating, potentially fatal T-lymphocyte malignancy affecting the skin. Despite all efforts, the etiology of this disease remains unknown.
Assia Angelova, Jean Rommelaere, Guy Ungerechts   +2 more
doaj   +1 more source

A Highly Expressing, Soluble, and Stable Plant-Made IgG Fusion Vaccine Strategy Enhances Antigen Immunogenicity in Mice Without Adjuvant

Frontiers in Immunology, 2020
Therapeutics based on fusing a protein of interest to the IgG Fc domain have been enormously successful, though fewer studies have investigated the vaccine potential of IgG fusions.
Andrew G. Diamos, Andrew G. Diamos, Mary D. Pardhe, Mary D. Pardhe, Haiyan Sun, Haiyan Sun, Joseph G. L. Hunter, Joseph G. L. Hunter, Jacquelyn Kilbourne, Jacquelyn Kilbourne, Qiang Chen, Qiang Chen, Hugh S. Mason, Hugh S. Mason   +13 more
doaj   +1 more source

Multiscale model for the effects of adaptive immunity suppression on the viral therapy of cancer

, 2013
Oncolytic virotherapy - the use of viruses that specifically kill tumor cells - is an innovative and highly promising route for treating cancer. However, its therapeutic outcomes are mainly impaired by the host immune response to the viral infection.
Ferreira, Silvio C, Martins, Marcelo L, Paiva, Leticia R, Silva, Hallan S   +3 more
core   +2 more sources

Targeting gene-virotherapy of cancer [PDF]

Cell Research, 2006
Our purpose is to completely elimination of xenograft tumor in animal tumor model in order to work out a protocal for the cure of patient. Gene therapy and viral therapy for cancer have got some therapeutic effects, but both have no great breakthrough.
Xinyuan Liu, Jin Fa Gu
openaire   +3 more sources

Overcoming therapeutic resistance in oncolytic herpes virotherapy by targeting IGF2BP3-induced NETosis in malignant glioma

Nature Communications
Oncolytic virotherapy holds promise for cancer treatment, but the factors determining its oncolytic activity remain unclear. Neutrophil extracellular traps (NETs) are associated with cancer progression, yet their formation mechanism and role in oncolytic
Weiwei Dai, Ruotong Tian, Liubing Yu, Shasha Bian, Yuling Chen, Bowen Yin, Yuxuan Luan, Siqi Chen, Zhuoyang Fan, Rucheng Yan, Xin Pan, Yingyong Hou, Rong Li, Juxiang Chen, Minfeng Shu   +14 more
semanticscholar   +1 more source

Deep learning of magnetic resonance fingerprints for the quantitative imaging of apoptosis following oncolytic virotherapy

Nature Biomedical Engineering, 2021
Non-invasive imaging methods for detecting intratumoural viral spread and host responses to oncolytic virotherapy are either slow, lack specificity or require the use of radioactive or metal-based contrast agents.
O. Perlman, Hirotaka Ito, K. Herz, Naoyuki Shono, H. Nakashima, M. Zaiss, E. Chiocca, Ouri Cohen, M. Rosen, C. Farrar   +9 more
semanticscholar   +1 more source

Autologous Transplantation Using Donor Leukocytes Loaded Ex Vivo with Oncolytic Myxoma Virus Can Eliminate Residual Multiple Myeloma

Molecular Therapy: Oncolytics, 2020
Multiple myeloma (MM) is a hematological malignancy of monoclonal plasma cells that remains incurable. Standard treatments for MM include myeloablative regimens and autologous cell transplantation for eligible patients.
Nancy.Y. Villa, Masmudur M. Rahman, Joseph. Mamola, Julia D’Isabella, Elizabeth Goras, Jacquelyn Kilbourne, Kenneth Lowe, Juliane Daggett-Vondras, Lino Torres, John Christie, Nicole Appel, Anna L. Cox, Jae B. Kim, Grant McFadden   +13 more
doaj