Results 71 to 80 of about 18,764 (290)

Magnetic‐Powered Janus Cell Robots Loaded with Oncolytic Adenovirus for Active and Targeted Virotherapy of Bladder Cancer

Advances in Materials, 2022
A unique robotic medical platform is designed by utilizing cell robots as the active “Trojan horse” of oncolytic adenovirus (OA), capable of tumor‐selective binding and killing.
Z. Cong, Songsong Tang, Leiming Xie, Ming Yang, Yangyang Li, Dongdong Lu, Jiahong Li, Qin-Zheng Yang, Qiwei Chen, Zhiqiang Zhang, Xueji Zhang, Song Wu   +11 more
semanticscholar   +1 more source

Oncolytic virotherapy for ovarian cancer [PDF]

Oncolytic Virotherapy, 2012
In the past two decades, more than 20 viruses with selective tropism for tumor cells have been developed as oncolytic viruses (OVs) for treatments of a variety of malignancies. Of these viruses, eleven have been tested in human ovarian cancer models in preclinical studies.
Li, Shoudong, Tong, Jessica, Rahman, Masmudur M., Shepherd, Trevor G., McFadden, Grant   +4 more
openaire   +4 more sources

Multimodal Therapy Approaches for NUT Carcinoma by Dual Combination of Oncolytic Virus Talimogene Laherparepvec with Small Molecule Inhibitors

Viruses
NUT (nuclear-protein-in-testis) carcinoma (NC) is a highly aggressive tumor disease. Given that current treatment regimens offer a median survival of six months only, it is likely that this type of tumor requires an extended multimodal treatment approach
Stavros Sotiriadis, Julia Beil, Susanne Berchtold, Irina Smirnow, Andrea Schenk, Ulrich M. Lauer   +5 more
doaj   +1 more source

Modeling dynamics of cancer virotherapy with immune response

Advances in Difference Equations, 2020
Virotherapy is a therapeutic treatment for cancer. It uses genetically engineered viruses to selectively infect, replicate in, and destroy cancer cells without damaging normal cells.
Salma M. Al-Tuwairqi, Najwa O. Al-Johani, Eman A. Simbawa   +2 more
doaj   +1 more source

Oncolytic Herpes Simplex Virus Inhibits Pediatric Brain Tumor Migration and Invasion [PDF]

, 2017
Paediatric high grade glioma (pHGG) and diffuse intrinsic pontine glioma (DIPG) are invasive tumours with poor survival. Oncolytic virotherapy, initially devised as a direct cytotoxic treatment, is now also known to act via immune-mediated mechanisms ...
Bartolini, Caretti, Cockle, Cockle, Demuth, Dumontet, Etienne-Manneville, Etienne-Manneville, Etienne-Manneville, Fangusaro, Ganguly, Grimes, Hargrave, Harrow, Jones, Kaufman, Khatua, Kirschner, Liao, Louis, Louis, Luo, Lyman, Naghavi, Papanastassiou, Peris, Prestwich, Radtke, Rampling, Reed, Russell, Schroeder, Schulze, Sun, Taylor, Tran, Turnbull, Waterman-Storer, Wollmann   +38 more
core   +3 more sources

Multiscale model for the effects of adaptive immunity suppression on the viral therapy of cancer

, 2013
Oncolytic virotherapy - the use of viruses that specifically kill tumor cells - is an innovative and highly promising route for treating cancer. However, its therapeutic outcomes are mainly impaired by the host immune response to the viral infection.
Ferreira, Silvio C, Martins, Marcelo L, Paiva, Leticia R, Silva, Hallan S   +3 more
core   +2 more sources

Overcoming therapeutic resistance in oncolytic herpes virotherapy by targeting IGF2BP3-induced NETosis in malignant glioma

Nature Communications
Oncolytic virotherapy holds promise for cancer treatment, but the factors determining its oncolytic activity remain unclear. Neutrophil extracellular traps (NETs) are associated with cancer progression, yet their formation mechanism and role in oncolytic
Weiwei Dai, Ruotong Tian, Liubing Yu, Shasha Bian, Yuling Chen, Bowen Yin, Yuxuan Luan, Siqi Chen, Zhuoyang Fan, Rucheng Yan, Xin Pan, Yingyong Hou, Rong Li, Juxiang Chen, Minfeng Shu   +14 more
semanticscholar   +1 more source

Oncolytic Virotherapy for High-Grade Glioma and Current Evidence and Factors to Consider for Incorporation into Clinical Practice

Pathogens, 2023
Brain tumor incidence is on the rise, and glioblastoma comprises the majority of primary tumors. Despite maximal safe resection and adjuvant chemoradiation, median survival for high-grade glioma remains poor.
Sauson Soldozy, D. Eichberg, Alexis A. Morell, E. Luther, Victor M Lu, Dominic M. O. Higgins, Nitesh V Patel, Ashish H. Shah, S. Hanft, R. Komotar, Michael E. Ivan   +10 more
semanticscholar   +1 more source

Oncolytic Virotherapy: A New Paradigm in Cancer Immunotherapy

International Journal of Molecular Sciences
Oncolytic viruses (OVs) are emerging as potential treatment options for cancer. Natural and genetically engineered viruses exhibit various antitumor mechanisms.
S. Volovat, D. Scripcariu, I. Vasilache, C. Stolniceanu, C. Volovăț, I. Augustin, C. Volovăț, Mădălina-Raluca Ostafe, Slevoacă-Grigore Andreea-Voichița, Toni Bejusca-Vieriu, C. Lungulescu, D. Sur, Diana Boboc   +12 more
semanticscholar   +1 more source

Tumor Tropism of DNA Viruses for Oncolytic Virotherapy

Viruses, 2023
Oncolytic viruses (OVs) have emerged as one of the most promising cancer immunotherapy agents that selectively target and kill cancer cells while sparing normal cells. OVs are from diverse families of viruses and can possess either a DNA or an RNA genome.
J. Enow, Hummad I. Sheikh, Masmudur M. Rahman   +2 more
semanticscholar   +1 more source