Results 241 to 250 of about 539,354 (299)

Optimal Dose and Safety of Intravenous Favipiravir in Hospitalized Patients With COVID‐19: A Dose‐Escalating, Randomized Controlled Phase Ib Study

Clinical Pharmacology &Therapeutics, EarlyView.
AGILE (NCT04746183) is a Phase Ib/IIa platform, evaluating candidates to treat COVID‐19. Candidate Specific Trial 6 evaluated the safety and optimal dose of a novel intravenous formulation of favipiravir in a dose‐escalating, open‐label, randomized, controlled, Bayesian adaptive Phase Ib trial.
Tim Rowland, Richard FitzGerald, Elizabeth Challenger, Laura Dickinson, Laura J. Else, Lauren Walker, Colin Hale, Victoria Shaw, Callum Kelly, Rebecca Lyon, Jennifer Gibney, Karim Dhamani, Margaret Irwin, Yvanne Enever, Michelle Tetlow, William Wood, Helen Reynolds, Justin Chiong, Orod Osanlou, Henry Pertinez, Katie Bullock, William Greenhalf, Andrew Owen, David G. Lalloo, Michael Jacobs, Julian A. Hiscox, Thomas Jaki, Pavel Mozgunov, Geoffrey Saunders, Gareth Griffiths, Saye H. Khoo, Thomas E. Fletcher, on behalf of the AGILE CST‐6 Study Group, Shazaad Ahmad, Christopher J. Edwards, Lesley Dry, Georgie McKenzie, Aleksandra Ros, Michael Stackpoole, Laura Bradley, Karen Jennings‐Wilding, Nicholas Paton, Fred Hayden, Janet Darbyshire, Amy Lucas, Ulrika Lorch, Andrew Freedman, Richard Knight, Steven Julious   +48 more
wiley   +1 more source

Coverage and quality of patient participation groups: a mixed-methods analysis of Care Quality Commission reports. [PDF]

Br J Gen Pract
Boam EJ, Munford L, Planner C, Rushforth B, Drinkwater J.   +4 more
europepmc   +1 more source

D.2.1.1 Consolidated Requirements Report, Roadmap and SIMDAT Infrastructure Design

, 2005
Boniface, M. J., Ferris, J., Kruger, M., Surridge, M., Tsasakou, S. K.   +4 more
core  

Is a Clinical Trial With a Non‐Bioequivalent Batch Necessary? The Critical Role of Intrasubject Variability in Olaparib Formulation Bridging by PBPK

Clinical Pharmacology &Therapeutics, EarlyView.
Although physiologically based pharmacokinetic (PBPK) modeling is increasingly being used to support oral drug formulation bridging, the acceptance by regulatory agencies is low. One of the primary concerns is the absence of clinical pharmacokinetic (PK) data from a non‐bioequivalent (non‐BE) batch during model validation.
Jin Dong, Andrea Moir, Xavier Pepin, Elizabeth Lowe, Sandy Hopkins, Weifeng Tang, Diansong Zhou   +6 more
wiley   +1 more source

Copernicus Data Space Ecosystem establishes public cloud processing for earth observation data. [PDF]

Sci Data
D Kovács D, Musial J, Bojanowski J, Clarijs D, de la Mar J, Zlinszky A.   +5 more
europepmc   +1 more source

Sudan at War With Itself: Civilian Devastation in the Civil War

Conflict Resolution Quarterly, EarlyView.
ABSTRACT A civil war is raging in Sudan between the Sudan Armed Forces (SAF) and the Rapid Support Forces (RSF) along with militia groups. Beginning on April 15, 2023, and continuing at least to this writing (October 15, 2025), civilian noncombatants have been subjected to bombings, beatings, torture, shootings, rape, and murder on a large scale. Since
Daniel Rothbart, Bayan Abubakr, Beltina Gjeloshi, Dieter Pfoser   +3 more
wiley   +1 more source

Mapping the US Bridgebuilding Field: Situating Organizations in the Ecosystem of Social Change

Conflict Resolution Quarterly, EarlyView.
ABSTRACT This article explores the ecosystem of bridge‐building initiatives in the United States. Drawing on an original database of 223 organizations, interviews with 7 staff across 6 organizations, and a literature review related to bridge‐building, polarization, and collective action, we first describe the range of existing initiatives and their ...
Gabrielle Mathews, Karen Ross
wiley   +1 more source

Adolescent mental health utilization, virtual care, and community support: evidence from 2019 to 2022. [PDF]

Front Public Health
Zhou WY, Franzini L, Bustamante AV.
europepmc   +1 more source

Guidelines for Implementing and Maintaining Virtual Reference Services

Reference & User Services Quarterly, 2010
openaire   +2 more sources

An Integrated Cyber-Physical Digital Twin Architecture with Quantitative Feedback Theory Robust Control for NIS2-Aligned Industrial Robotics. [PDF]

Sensors (Basel)
Karlova-Sergieva V, Grasiani B, Nikolova N.   +2 more
europepmc   +1 more source