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A highly conserved sRNA downregulates multiple genes, including a σ<sup>54</sup> transcriptional activator, in the virulence mode of <i>Bordetella pertussis</i>. [PDF]
Sim M +14 more
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Global analysis of the Hfq-mediated RNA interactome discovers a MicA homolog that affects the cytotoxicity, biofilm formation, and resistance to complement of Bordetella pertussis. [PDF]
Kumar D +10 more
europepmc +1 more source
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Virulence factors of Bordetella pertussis
Antonie Van Leeuwenhoek, 1988Clearly, B. pertussis has evolved very elaborate mechanisms to maintain itself in the human host. Three different proteins (FHA, pertussis toxin and fimbriae) have been implicated in adherence. Furthermore, a number of toxins are produced (pertussis toxin, adenylate cyclase, dermonecrotic toxin, and tracheal cytotoxin) which destroy the clearance ...
Frits R Mooi, Mooi Frits R
exaly +5 more sources
Virulence Factors of Bordetella Pertussis
Annual Review of Microbiology, 1986E L Hewlett, A A Weiss
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Differential Regulation of Bordetella pertussis Virulence Factors
Zentralblatt für Bakteriologie, 1993Bordetella pertussis, the causative agent of whooping cough, regulates its virulence factors coordinately according to environmental parameters such as temperature and certain chemicals. A regulatory locus has been characterized which is essential for this regulation.
R, Gross, N H, Carbonetti
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Environmental regulation of virulence factors in Bordetella species
BioEssays, 1993AbstractMany bacteria respond in a coordinate manner to environmental changes. External stimuli, sensed by receptors, are transduced to regulatory proteins which participate in well defined pathways of gene expression by varying their structure and mode of action. The network of environmental signal transduction is responsible for a fine and continuous
Scarlato V. +3 more
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Bordetella adenylate cyclase is a virulence associated factor and an immunoprotective antigen
Microbial Pathogenesis, 1989Bordetella pertussis and Bordetella parapertussis are both causative agents of whooping cough outbreaks. Although not expressing the pertussis toxin, B. parapertussis induces, in a murine model, an acute hemorrhagic edematous alveolitis, similar to that observed with B. pertussis.
N, Guiso +3 more
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Structure of Bordetella pertussis virulence factor P.69 pertactin
Nature, 1996A new generation of whooping-cough vaccines contain P.69 pertactin, a surface-exposed domain of an outer membrane protein expressed by the virulent bacterium Bordetella pertussis. This protein is a virulence factor that mediates adhesion to target mammalian cells, a reaction that is in part mediated by an RGD sequence.
P, Emsley +3 more
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