Results 141 to 150 of about 7,870 (170)

Pertussis Toxin and Extracytoplasmic Adenylate Cyclase as Virulence Factors of Bordetella pertussis

Journal of Infectious Diseases, 1984
A wild-type strain of Bordetella pertussis and a series of transposon Tn5-induced mutants deficient in the production of various factors believed to play a role in pertussis (whooping cough) were tested for virulence in infant mice. The 50% lethal dose of the wild-type strain in these animals was 2 X 10(3) bacteria. A mutant deficient in the production
A A, Weiss, E L, Hewlett, G A, Myers, S, Falkow   +3 more
openaire   +2 more sources

The Virulence Factors of Bordetella pertussis: Talented Modulators of Host Immune Response

Archivum Immunologiae et Therapiae Experimentalis, 2013
Approximately 40 million whooping cough cases and between 200,000 and 400,000 pertussis-linked deaths are recorded each year. Although several types of vaccines are licensed and widely used, Bordetella pertussis continues to circulate in populations with high vaccine coverage of infants and children due to the waning of protection induced by the ...
Giorgio, Fedele, Manuela, Bianco, Clara Maria, Ausiello   +2 more
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Tracheal colonization factor: a Bordetella pertussis secreted virulence determinant

Molecular Microbiology, 1995
SummaryWe report here the identification of a virulence‐associated factor, Tcf, (tracheal colonization factor), produced by strains of Bordetella pertussis but not Bordetella parapertussis or Bordetella bronchiseptica. This protein is encoded by the tcfA gene. When a strain of B.
T M, Finn, L A, Stevens
openaire   +2 more sources

Antibody responses to defined regions of theBordetella pertussisvirulence factor pertactin

Scandinavian Journal of Infectious Diseases, 2008
Although vaccines against Bordetella pertussis, the causative agent of whooping cough, have been in use for over 50 y, the disease has remained endemic and is still a public health problem in many countries. It has been shown that antibody titres against pertactin, which is 1 of the exposed virulence factors of pertussis, correlate with protection and ...
Marcel, Hijnen, Qiushui, He, Rutger, Schepp, Pieter, Van Gageldonk, Jussi, Mertsola, Frits R, Mooi, Guy A M, Berbers   +6 more
openaire   +2 more sources

DERMONECROTIC TOXIN: THE OLD BUT NEW VIRULENCE FACTOR PRODUCED BY BORDETELLA SPP.

Toxin Reviews, 2006
Bordetella dermonecrotic toxin (DNT) is a virulence factor produced by bacteria belonging to the genus Bordetella including B. pertussis, B. parapertussis, and B. bronchiseptica. Intensive studies have clarified the structure and function of DNT in the last decade long after its discovery by Bordet and Gengou ().
Aya Fukui, Yasuhiko Horiguchi
openaire   +1 more source

Bordetella Pertussis virulence factors in the continuing evolution of whooping cough vaccines for improved performance

Medical Microbiology and Immunology, 2017
Despite high vaccine coverage, whooping cough caused by Bordetella pertussis remains one of the most common vaccine-preventable diseases worldwide. Introduction of whole-cell pertussis (wP) vaccines in the 1940s and acellular pertussis (aP) vaccines in 1990s reduced the mortality due to pertussis.
Dorji, Mooi, F., Yantorno, O., Deora, R., Graham, Ross, Mukkur, Trilochan   +5 more
openaire   +5 more sources

Mutations in the linker region of Bvgs abolish response to environmental signals for the regulation of the virulence factors in bordetella pertussis

Gene, 1994
Expression of virulence factors of Bordetella pertussis is coordinately regulated by the products of the bvg locus, which codes for a sensory protein (BvgS) and a positive regulator of transcription (BvgA), a pair in the family of bacterial 'two-component' regulators. Transcription of the bvg-regulated promoters is repressed by modulating environmental
Manetti R., Arico B., Rappuoli R., Scarlato V.   +3 more
openaire   +3 more sources

Regulatory factors of Bordetella pertussis affecting virulence gene expression.

Journal of molecular microbiology and biotechnology, 2002
Most pathogenic bacteria encounter changing growth conditions during their infectious cycle and, accordingly, have to modulate gene expression to enable the efficient colonization of different environments outside or within their host organisms. In Bordetella pertussis the transcription of most virulence factors including several toxins and adhesins is
Jochen, König, Andreas, Bock, Anne-Laure, Perraud, Thilo M, Fuchs, Dagmar, Beier, Roy, Gross   +5 more
openaire   +1 more source

Leveraging Bordetella heterogeneity to identify novel virulence factors

Pertussis (aka whooping cough) is a serious, re-emerging public health concern despite available vaccines. The acellular vaccine against Bordetella pertussis, used in the U.S. since the 1990s, prevents serious disease, but not colonization or transmission, resulting in a larger reservoir from which infants, who are most vulnerable, can be infected. New
openaire   +1 more source

Bacterial growth and virulence factors production by different Bordetella pertussis strains.

Acta microbiologica Polonica, 1997
The aim of this study was to compare bacteria growth and pertussis antigens (pertussis toxin-PT, filamentous haemagglutinin-FHA and endotoxin-LPS) production by 11 Bordetella pertussis strains. A synthetic Stainer-Scholte culture medium supplemented with (2,6-0-dimethyl) beta-cyclodextrin (heptakis) or methylcellulose (for greater PT and FHA production)
I, Letowska, M, Chodorowska, E, Kaczurba, D, Kuklińska, S, Tyski   +4 more
openaire   +1 more source