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Bordetella Dermonecrotic Toxin Is a Neurotropic Virulence Factor That Uses CaV3.1 as the Cell Surface Receptor

open access: yesBordetella Dermonecrotic Toxin Is a Neurotropic Virulence Factor That Uses CaV3.1 as the Cell Surface Receptor
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Virulence factors of Bordetella pertussis

Antonie Van Leeuwenhoek, 1988
Clearly, B. pertussis has evolved very elaborate mechanisms to maintain itself in the human host. Three different proteins (FHA, pertussis toxin and fimbriae) have been implicated in adherence. Furthermore, a number of toxins are produced (pertussis toxin, adenylate cyclase, dermonecrotic toxin, and tracheal cytotoxin) which destroy the clearance ...
Frits R Mooi, Mooi Frits R
exaly   +5 more sources

Bordetella Pertussis virulence factors in the continuing evolution of whooping cough vaccines for improved performance

open access: yesMedical Microbiology and Immunology, 2017
Despite high vaccine coverage, whooping cough caused by Bordetella pertussis remains one of the most common vaccine-preventable diseases worldwide. Introduction of whole-cell pertussis (wP) vaccines in the 1940s and acellular pertussis (aP) vaccines in 1990s reduced the mortality due to pertussis.
Dorji   +5 more
openaire   +6 more sources

DERMONECROTIC TOXIN: THE OLD BUT NEW VIRULENCE FACTOR PRODUCED BY BORDETELLA SPP.

Toxin Reviews, 2006
Bordetella dermonecrotic toxin (DNT) is a virulence factor produced by bacteria belonging to the genus Bordetella including B. pertussis, B. parapertussis, and B. bronchiseptica. Intensive studies have clarified the structure and function of DNT in the last decade long after its discovery by Bordet and Gengou ().
Yasuhiko Horiguchi
exaly   +2 more sources

Virulence Factors of Bordetella Pertussis

Annual Review of Microbiology, 1986
Alison A Weiss, Erik L Hewlett
exaly   +4 more sources

Bordetella PlrSR regulatory system controls BvgAS activity and virulence in the lower respiratory tract

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2017
Bordetella spp. includes Bordetella pertussis, the causal agent of whooping cough. The Bordetella virulence gene (BvgAS) two-component regulatory system (TCS) is considered the “master virulence regulator” in Bordetella, as it controls expression of all ...
Andrew I Perault   +2 more
exaly   +3 more sources

Role of the Putative Histidine Kinase BP1092 in Bordetella pertussis Virulence Regulation and Intracellular Survival

open access: yesJournal of Proteome Research
Bordetella pertussis persists inside host cells, and virulence factors are crucial for intracellular adaptation. The regulation of B. pertussis virulence factor transcription primarily occurs through the modulation of the two-component system (TCS) known
Martina Debandi   +2 more
exaly   +6 more sources

Differential Regulation of Bordetella pertussis Virulence Factors

Zentralblatt für Bakteriologie, 1993
Bordetella pertussis, the causative agent of whooping cough, regulates its virulence factors coordinately according to environmental parameters such as temperature and certain chemicals. A regulatory locus has been characterized which is essential for this regulation.
R, Gross, N H, Carbonetti
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Environmental regulation of virulence factors in Bordetella species

BioEssays, 1993
AbstractMany bacteria respond in a coordinate manner to environmental changes. External stimuli, sensed by receptors, are transduced to regulatory proteins which participate in well defined pathways of gene expression by varying their structure and mode of action. The network of environmental signal transduction is responsible for a fine and continuous
Scarlato V.   +3 more
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