Results 171 to 180 of about 8,047 (199)

Bordetella adenylate cyclase is a virulence associated factor and an immunoprotective antigen

Microbial Pathogenesis, 1989
Bordetella pertussis and Bordetella parapertussis are both causative agents of whooping cough outbreaks. Although not expressing the pertussis toxin, B. parapertussis induces, in a murine model, an acute hemorrhagic edematous alveolitis, similar to that observed with B. pertussis.
N, Guiso, M, Rocancourt, M, Szatanik, J M, Alonso   +3 more
openaire   +2 more sources

Structure of Bordetella pertussis virulence factor P.69 pertactin

Nature, 1996
A new generation of whooping-cough vaccines contain P.69 pertactin, a surface-exposed domain of an outer membrane protein expressed by the virulent bacterium Bordetella pertussis. This protein is a virulence factor that mediates adhesion to target mammalian cells, a reaction that is in part mediated by an RGD sequence.
P, Emsley, I G, Charles, N F, Fairweather, N W, Isaacs   +3 more
openaire   +2 more sources

Pertussis Toxin and Extracytoplasmic Adenylate Cyclase as Virulence Factors of Bordetella pertussis

Journal of Infectious Diseases, 1984
A wild-type strain of Bordetella pertussis and a series of transposon Tn5-induced mutants deficient in the production of various factors believed to play a role in pertussis (whooping cough) were tested for virulence in infant mice. The 50% lethal dose of the wild-type strain in these animals was 2 X 10(3) bacteria. A mutant deficient in the production
A A, Weiss, E L, Hewlett, G A, Myers, S, Falkow   +3 more
openaire   +2 more sources

The Virulence Factors of Bordetella pertussis: Talented Modulators of Host Immune Response

Archivum Immunologiae et Therapiae Experimentalis, 2013
Approximately 40 million whooping cough cases and between 200,000 and 400,000 pertussis-linked deaths are recorded each year. Although several types of vaccines are licensed and widely used, Bordetella pertussis continues to circulate in populations with high vaccine coverage of infants and children due to the waning of protection induced by the ...
Giorgio, Fedele, Manuela, Bianco, Clara Maria, Ausiello   +2 more
openaire   +2 more sources

Tracheal colonization factor: a Bordetella pertussis secreted virulence determinant

Molecular Microbiology, 1995
SummaryWe report here the identification of a virulence‐associated factor, Tcf, (tracheal colonization factor), produced by strains of Bordetella pertussis but not Bordetella parapertussis or Bordetella bronchiseptica. This protein is encoded by the tcfA gene. When a strain of B.
T M, Finn, L A, Stevens
openaire   +2 more sources

Antibody responses to defined regions of theBordetella pertussisvirulence factor pertactin

Scandinavian Journal of Infectious Diseases, 2008
Although vaccines against Bordetella pertussis, the causative agent of whooping cough, have been in use for over 50 y, the disease has remained endemic and is still a public health problem in many countries. It has been shown that antibody titres against pertactin, which is 1 of the exposed virulence factors of pertussis, correlate with protection and ...
Marcel, Hijnen, Qiushui, He, Rutger, Schepp, Pieter, Van Gageldonk, Jussi, Mertsola, Frits R, Mooi, Guy A M, Berbers   +6 more
openaire   +2 more sources

Mutations in the linker region of Bvgs abolish response to environmental signals for the regulation of the virulence factors in bordetella pertussis

Gene, 1994
Expression of virulence factors of Bordetella pertussis is coordinately regulated by the products of the bvg locus, which codes for a sensory protein (BvgS) and a positive regulator of transcription (BvgA), a pair in the family of bacterial 'two-component' regulators. Transcription of the bvg-regulated promoters is repressed by modulating environmental
Manetti R., Arico B., Rappuoli R., Scarlato V.   +3 more
openaire   +3 more sources

Regulatory factors of Bordetella pertussis affecting virulence gene expression.

Journal of molecular microbiology and biotechnology, 2002
Most pathogenic bacteria encounter changing growth conditions during their infectious cycle and, accordingly, have to modulate gene expression to enable the efficient colonization of different environments outside or within their host organisms. In Bordetella pertussis the transcription of most virulence factors including several toxins and adhesins is
Jochen, König, Andreas, Bock, Anne-Laure, Perraud, Thilo M, Fuchs, Dagmar, Beier, Roy, Gross   +5 more
openaire   +1 more source

Bacterial growth and virulence factors production by different Bordetella pertussis strains.

Acta microbiologica Polonica, 1997
The aim of this study was to compare bacteria growth and pertussis antigens (pertussis toxin-PT, filamentous haemagglutinin-FHA and endotoxin-LPS) production by 11 Bordetella pertussis strains. A synthetic Stainer-Scholte culture medium supplemented with (2,6-0-dimethyl) beta-cyclodextrin (heptakis) or methylcellulose (for greater PT and FHA production)
I, Letowska, M, Chodorowska, E, Kaczurba, D, Kuklińska, S, Tyski   +4 more
openaire   +1 more source

Bordetella adenylate cyclase: a genus specific protective antigen and virulence factor.

Developments in biological standardization, 1986
Most of the adenylate cyclase (AC) present in Bordetella species is localized in the outer membrane, partly exposed to the cell surface. An isolation procedure to obtain the cell-bound enzyme was applied to Bordetella bronchiseptica, Bordetella pertussis and Bordetella parapertussis. Passive transfer of B. bronchiseptica anti-AC antibody, either in the
P, Novotny, A P, Chubb, K, Cownley, J A, Montaraz, J E, Beesley   +4 more
openaire   +1 more source