Results 181 to 190 of about 13,827 (215)

Differential Regulation of Bordetella pertussis Virulence Factors

Zentralblatt für Bakteriologie, 1993
Bordetella pertussis, the causative agent of whooping cough, regulates its virulence factors coordinately according to environmental parameters such as temperature and certain chemicals. A regulatory locus has been characterized which is essential for this regulation.
R, Gross, N H, Carbonetti
openaire   +2 more sources

Environmental regulation of virulence factors in Bordetella species

BioEssays, 1993
AbstractMany bacteria respond in a coordinate manner to environmental changes. External stimuli, sensed by receptors, are transduced to regulatory proteins which participate in well defined pathways of gene expression by varying their structure and mode of action. The network of environmental signal transduction is responsible for a fine and continuous
Scarlato V., Arico B., Domenighini M., Rappuoli R.   +3 more
openaire   +3 more sources

Bordetella adenylate cyclase is a virulence associated factor and an immunoprotective antigen

Microbial Pathogenesis, 1989
Bordetella pertussis and Bordetella parapertussis are both causative agents of whooping cough outbreaks. Although not expressing the pertussis toxin, B. parapertussis induces, in a murine model, an acute hemorrhagic edematous alveolitis, similar to that observed with B. pertussis.
N, Guiso, M, Rocancourt, M, Szatanik, J M, Alonso   +3 more
openaire   +2 more sources

Structure of Bordetella pertussis virulence factor P.69 pertactin

Nature, 1996
A new generation of whooping-cough vaccines contain P.69 pertactin, a surface-exposed domain of an outer membrane protein expressed by the virulent bacterium Bordetella pertussis. This protein is a virulence factor that mediates adhesion to target mammalian cells, a reaction that is in part mediated by an RGD sequence.
P, Emsley, I G, Charles, N F, Fairweather, N W, Isaacs   +3 more
openaire   +2 more sources

Pertussis Toxin and Extracytoplasmic Adenylate Cyclase as Virulence Factors of Bordetella pertussis

Journal of Infectious Diseases, 1984
A wild-type strain of Bordetella pertussis and a series of transposon Tn5-induced mutants deficient in the production of various factors believed to play a role in pertussis (whooping cough) were tested for virulence in infant mice. The 50% lethal dose of the wild-type strain in these animals was 2 X 10(3) bacteria. A mutant deficient in the production
A A, Weiss, E L, Hewlett, G A, Myers, S, Falkow   +3 more
openaire   +2 more sources

The Virulence Factors of Bordetella pertussis: Talented Modulators of Host Immune Response

Archivum Immunologiae et Therapiae Experimentalis, 2013
Approximately 40 million whooping cough cases and between 200,000 and 400,000 pertussis-linked deaths are recorded each year. Although several types of vaccines are licensed and widely used, Bordetella pertussis continues to circulate in populations with high vaccine coverage of infants and children due to the waning of protection induced by the ...
Giorgio, Fedele, Manuela, Bianco, Clara Maria, Ausiello   +2 more
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Tracheal colonization factor: a Bordetella pertussis secreted virulence determinant

Molecular Microbiology, 1995
SummaryWe report here the identification of a virulence‐associated factor, Tcf, (tracheal colonization factor), produced by strains of Bordetella pertussis but not Bordetella parapertussis or Bordetella bronchiseptica. This protein is encoded by the tcfA gene. When a strain of B.
T M, Finn, L A, Stevens
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DERMONECROTIC TOXIN: THE OLD BUT NEW VIRULENCE FACTOR PRODUCED BY BORDETELLA SPP.

Toxin Reviews, 2006
Bordetella dermonecrotic toxin (DNT) is a virulence factor produced by bacteria belonging to the genus Bordetella including B. pertussis, B. parapertussis, and B. bronchiseptica. Intensive studies have clarified the structure and function of DNT in the last decade long after its discovery by Bordet and Gengou ().
Yasuhiko Horiguchi
exaly   +2 more sources

Antibody responses to defined regions of theBordetella pertussisvirulence factor pertactin

Scandinavian Journal of Infectious Diseases, 2008
Although vaccines against Bordetella pertussis, the causative agent of whooping cough, have been in use for over 50 y, the disease has remained endemic and is still a public health problem in many countries. It has been shown that antibody titres against pertactin, which is 1 of the exposed virulence factors of pertussis, correlate with protection and ...
Marcel, Hijnen, Qiushui, He, Rutger, Schepp, Pieter, Van Gageldonk, Jussi, Mertsola, Frits R, Mooi, Guy A M, Berbers   +6 more
openaire   +2 more sources

Bordetella Pertussis virulence factors in the continuing evolution of whooping cough vaccines for improved performance

Medical Microbiology and Immunology, 2017
Despite high vaccine coverage, whooping cough caused by Bordetella pertussis remains one of the most common vaccine-preventable diseases worldwide. Introduction of whole-cell pertussis (wP) vaccines in the 1940s and acellular pertussis (aP) vaccines in 1990s reduced the mortality due to pertussis.
Dorji, Mooi, F., Yantorno, O., Deora, R., Graham, Ross, Mukkur, Trilochan   +5 more
openaire   +5 more sources