Results 181 to 190 of about 244,966 (265)

A standardized surgical technique for DAIR improves treatment success rates in acute periprosthetic knee infection

open access: yesKnee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose Results after debridement, antibiotics and implant retention (DAIR) for acute periprosthetic knee joint infections (PJIs) vary widely. Although data are limited, surgeon expertise and surgical technique likely influence outcomes. Standardized DAIR performed by surgeons within a multidisciplinary team (MDT) dedicated to the treatment of
Guillermo Sánchez‐Rosenberg   +4 more
wiley   +1 more source

Glyco‐Nanogels for Modulating Pseudomonas aeruginosa Biofilm

open access: yesMacromolecular Rapid Communications, EarlyView.
Nanogels presenting α‐galactose and β‐fucose can significantly alter Pseudomonas aeruginosa biofilm dynamics through their interaction with lectins. Application timing is crucial: pre‐treatment reduces biofilm, while treatment after biofilm initiation increases biomass.
Sophia Rosencrantz   +4 more
wiley   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood   +7 more
wiley   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

A DUF3455 domain‐containing protein promotes Ustilaginoidea virens infection and functions as a plant immune elicitor

open access: yesNew Plant Protection, EarlyView.
The fungal effector UvDUF1 from Ustilaginoidea virens not only promotes infection but also acts as a plant immunity elicitor, inducing broad‐spectrum disease resistance in rice and Nicotiana benthamiana. These results reveal its potential as a novel target for sustainable crop protection strategies.
Shuchen Wang   +13 more
wiley   +1 more source

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