Biotechnology Progress, EarlyView.Abstract Traditional off‐line analysis methods to quantify residual metabolite concentrations in a drug substance fermentation process consume valuable time, require costly resources, and demand potentially hazardous manual operations when working with pathogenic biological organisms.
Griffin P. Thomas +7 more
wiley +1 more source
Transcriptome Analysis Reveals Cross-Kingdom Virulence Factors in Erwinia persicina Cp2. [PDF]
Environ Microbiol RepHuang R, Liu XN, Hsiang T, Zhang ZF.
europepmc +1 more source
Chemistry – A European Journal, EarlyView.The SARS‐CoV‐2 papain‐like protease (PLpro) is a medicinal chemistry target. Here we report mass spectrometry assays employing oligopeptide substrates based on the sequences of the viral polyproteins 1a/1ab and on an ISG15‐modified human protein, which enabled the identification of substrate‐selective PLpro inhibitors.
Sakshi Sharma +13 more
wiley +1 more source
Prevalence of noncanonical virulence factors in the adherence and invasion by enterotoxigenic <i>Escherichia coli</i> in the small and large intestines. [PDF]
Front Cell Infect MicrobiolEspinosa-Mazariego K +7 more
europepmc +1 more source
Chemistry – A European Journal, EarlyView.A set of new phosphonomethyl (thio)phosphonamidite reagents is introduced to generate unprecedented pyrophosphate mimetics. The versatile P(III)‐P(V) reagents allow for the construction of various pyrophosphate isosteres, and the applicability of the chemistry is illustrated in the assembly of a diverse set of stabilized CDP‐glycerol and CDP‐ribitol ...
Pascal Balić +4 more
wiley +1 more source
DeepVIC: modular prediction and classification of bacterial virulence factors using protein language model embeddings. [PDF]
Bioinform AdvTsui WK, Chan YX, Chow KH, Ho PL, Cao H.
europepmc +1 more source
Repurposing Drugs for Malaria through a Human Dose Prediction: A Case Study with Berzosertib
Clinical Pharmacology &Therapeutics, EarlyView.Repurposing drugs whose clinical safety has been established offers a valuable approach to reduce the cost and time associated with the development of new drugs for malaria. Here, we investigate the potential to repurpose the anticancer kinase inhibitor berzosertib for the treatment of malaria, by assessing whether a predicted efficacious human dose ...
Devasha Redhi +5 more
wiley +1 more source
Genomic analysis of antibiotic resistance and virulence factors in the uropathogen <i>Citrobacter koseri</i>. [PDF]
Microb GenomStephens C +5 more
europepmc +1 more source
Morphological signatures of bacteria‐laden drying droplets: A multimodal analysis across host fluids
Droplet, EarlyView.Drying patterns of bacteria‐laden droplets encode concentration‐dependent signatures across three host fluids: serum, urine, and nutrient medium. By integrating time‐evolving texture descriptors, image features, and interpretable multimodal machine learning, this study demonstrates a label‐free approach for extracting information on bacterial ...
Anusuya Pal +6 more
wiley +1 more source
Vaginal host–microbe signatures linked to placental outcomes in mares
Equine Veterinary Journal, EarlyView.Abstract Background Ascending placentitis is a leading cause of late‐term pregnancy loss in mares. Although pathogens are presumed to ascend from the caudal reproductive tract, the association between the vaginal microbiome and placentitis has not been systematically examined.
Machteld van Heule +7 more
wiley +1 more source