Results 171 to 180 of about 2,134,385 (307)

MurNAc‐Based Electrophilic Inhibitors of O‐Acetylpeptidoglycan Esterase (Ape): Design, Synthesis, and Kinetic Evaluation

Chemistry – A European Journal, EarlyView.
A series of N‐acetylmuramic acid (MurNAc)‐based electrophilic inhibitors targeting Ape esterase was synthesized. Their inhibitory potency ranged from micromolar to submillimolar. The study probed binding contributions of stem peptide extension, replacing the anomeric methyl group with a benzyl, and α‐fluorination of the carbonyl to enhance ...
Dmytro Voskoboinyk, Martin E. Tanner
wiley   +1 more source

Molecular Characterization of Virulence Genes and Quinolone Resistance Determinants in <i>Salmonella</i> Strains from Retail Chicken Meat. [PDF]

Antibiotics (Basel)
Güran HŞ, Karacan Sever N, Bozdoğan B, Çiftçi R, Alali W, Doğan Y, Uçar U.   +6 more
europepmc   +1 more source

Vaginal host–microbe signatures linked to placental outcomes in mares

Equine Veterinary Journal, EarlyView.
Abstract Background Ascending placentitis is a leading cause of late‐term pregnancy loss in mares. Although pathogens are presumed to ascend from the caudal reproductive tract, the association between the vaginal microbiome and placentitis has not been systematically examined.
Machteld van Heule, Babiche Heil, Jamie K. Norris, Kristene Gedye, Xiaoxiao Lin, Ward De Spiegelaere, Peter Daels, Pouya Dini   +7 more
wiley   +1 more source

Genetic engineering of <i>Staphylococcus haemolyticus</i>: overcoming restriction-modification barriers and targeting virulence genes. [PDF]

Microb Genom
Venter HJ, Cavanagh JP, Wolden R, Jones D, Roberts RJ, Christensen MO, Zepeda-Rivera M, Johnston CD.   +7 more
europepmc   +1 more source

Cross‐protective effect of a multicomponent fusion protein vaccine during a natural episode of Streptococcus zooepidemicus respiratory disease in ponies

Equine Veterinary Journal, EarlyView.
Abstract Background Streptococcus equi subspecies zooepidemicus is a highly diverse opportunistic pathogen of horses, associated with respiratory disease and endometritis. Objectives To characterise S. zooepidemicus isolates recovered from young ponies during a natural episode of respiratory disease, and to determine if vaccination with Strangvac®, a ...
Romain Paillot, J. Richard Newton, Sonia Gonzalez Medina, Sara Frosth, Lars Frykberg, Margareta Flock, Bengt Guss, Jan‐Ingmar Flock, Andrew S. Waller   +8 more
wiley   +1 more source

Characterizing the antibiotic resistance and virulence genes of diarrheagenic Escherichia coli from Brazilian beef cattle. [PDF]

BMC Microbiol
de Melo Tavares R, Yamatogi RS, Call DR, Nero LA.   +3 more
europepmc   +1 more source

Challenges for interpreting results of antimicrobial susceptibility testing for treating infections of foals with Rhodococcus equi

Equine Veterinary Journal, EarlyView.
Abstract Rhodococcus equi is a facultative intracellular pathogen and a major cause of pneumonia in foals worldwide. The standard treatment for affected foals is a combination of a macrolide with rifampicin. The widespread use of this combination has led to the emergence of multidrug‐resistant (MDR) strains of R. equi.
Marlane Geribone Seeger, Letícia Trevisan Gressler, Laura Huber, Sonsiray Alvarez‐Narvaez, Juliana Felipetto Cargnelutti, Angela Ilha Bordin, Sara D. Lawhon, Noah D. Cohen   +7 more
wiley   +1 more source

A critical role of the histone lysine demethylase JmjC1 in regulating severe malaria-associated virulence genes in Plasmodium falciparum. [PDF]

Nat Commun
Tang R, Pang J, Deng Y, Jiao Z, Li A, Li Q, Wang C, Wang Z, Wang J, Li Y, Wang L, Zhang Y, Wang L, Zhi Y, Wu J, Jia J, Chen X, Jiang N, Chen Q, Liu Y, Shang X, Zhang Q.   +21 more
europepmc   +1 more source

Plant‐Derived Extracts Disrupt Biofilm Formation and Quorum Sensing in Yersinia enterocolitica: Insights From GC‐MS and Molecular Docking

Food Chemistry International, EarlyView.
The graphical abstract represents how natural plant products that preferentially target the specific receptors of quorum sensing could be developed to combat biofilms linked to Yersinia enterocolitica using the potent abilities of protein–ligand complexes with high docking scores.
Rajendran Thomas, Songeeta Singha, Devarshi Bharadwaj, Abinash Kumar, Dolly Sharma, Sadhana Ojha, Hirakjyoti Das, Vivek Kumar Gupta   +7 more
wiley   +1 more source

Associations of Biofilm Capacity with Antimicrobial Resistance and Virulence Genes in <i>Klebsiella pneumoniae</i> from Chickens in Henan, China, 2023-2025. [PDF]

Antibiotics (Basel)
Zhang H, Li J, Deng S, Lei J, Gao L, Li X, Gao L, Yuan Y, Wu H, Zhai Y, Liu J.   +10 more
europepmc   +1 more source