Results 181 to 190 of about 1,788,404 (210)

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Boronic Acid Inhibitors of β‐Lactamases: A Promising Strategy Against Antimicrobial Resistance

Medicinal Research Reviews, EarlyView.
ABSTRACT The rise of antimicrobial resistance (AMR) poses a critical threat to global health, mostly due to the proliferation of β‐lactamases, a class of enzymes responsible for the inactivation of β‐lactam antibiotics. Among the most promising strategies to restore β‐lactam efficacy is the use of β‐lactamase inhibitors (BLIs), with boronic acid ...
Nicolò Santi, Federico Corsini, Robert A. Bonomo, Emilia Caselli, Fabio Prati   +4 more
wiley   +1 more source

ISAba1‐mediated crp‐osmC amplification enhances host‐associated fitness in Acinetobacter baumannii

mLife, EarlyView.
Abstract Acinetobacter baumannii is a pathogen, highly adaptable to both hospital‐ and host‐associated environments. Understanding the genetic mechanisms underlying its adaptability is critical for controlling its persistence. Our study identified the crp‐osmC gene cluster, flanked by ISAba1 elements, as a significant genetic structure undergoing ...
Da‐Wei Wei, Jiangqing Huang, Hailing Fang, Xinyu Wang, Gang Zhang, Chao Wang, Yuqin Song, Jie Feng   +7 more
wiley   +1 more source

Redefining Acne as a Distinct Inflammatory Disease: Acne Is Not an Aesthetic Issue

JEADV Clinical Practice, EarlyView.
Jean Paul Claudel, Fabienne Ballanger, Nicole Auffret, Marie‐Thérèse Leccia, Brigitte Dréno   +4 more
wiley   +1 more source

Harnessing plant susceptibility genes into strategies for enhanced disease resistance

New Plant Protection, EarlyView.
Integrated model of S gene modules in plant pathogen interactions. This model summarises representative host susceptibility modules that can be exploited by bacterial, fungal and viral pathogens. In the bacterial infection module, Xanthomonas transcription activator‐like effectors activate OsSWEET14 through effector‐binding elements in its promoter ...
Can Chen, Yuzhe Shi, Hanwen Miao, Ning Wang, Xiaojie Wang   +4 more
wiley   +1 more source

Host suitability of Mediterranean olive (Olea europaea L.) varieties to two root‐knot nematode species (Meloidogyne javanica and M. incognita) under greenhouse conditions

New Plant Protection, EarlyView.
Root‐knot nematodes significantly threaten olive production in Morocco. Screening of seven olive varieties revealed strong resistance in Koroneiki and Picholine Marocaine, characterized by suppressed nematode reproduction, sustained plant growth, and enhanced defense responses.
Salah‐Eddine Laasli, Abdelfattah A. Dababat, Fouad Mokrini, Elhassan Mayad, Amal Hari, Hajar El Hamss, Honglian Li, Rachid Lahlali   +7 more
wiley   +1 more source

Impact of the GouM transporter on secondary metabolism activation and production yield in Streptomyces noursei strain CK‐15

New Plant Protection, EarlyView.
Overexpression of the gouM transporter gene in Streptomyces noursei CK‐15 enhances gougerotin production by 114% and activates silent biosynthetic gene clusters. This finding links transporter activity to metabolite efflux and secondary metabolism, offering a strategy for natural product discovery and strain optimization.
Qianying Zhou, Hua Yu, Rouhallah Sharifi, Muhammad Usman, Shun Lai Ei, Abdel‐Hamied M. Rasmey, Beibei Ge   +6 more
wiley   +1 more source

Targeting homologous recombination repair to potentiate fluoroquinolone efficacy in Mycobacterium abscessus

mLife, EarlyView.
Shuai Wang, Md Shah Alam, Buhari Yusuf, Jingran Zhang, Ziwen Lu, Xiaofan Zhang, H. M. Adnan Hameed, Mst. Sumaia Khatun, Chunyu Li, Lijie Li, Aleksey A. Vatlin, Aweke M. Belachew, Xirong Tian, Yamin Gao, Cuiting Fang, Rogers P. Zhang, Jun Li, Xinyue Wang, Liqiang Feng, Li Wan, Tianyu Zhang   +20 more
wiley   +1 more source

Novel recombinant human adenoviruses: A call for enhanced molecular surveillance, diagnosis, and management in pediatric acute respiratory infections

Pediatric Investigation, EarlyView.
Zhen Zhu, Naiying Mao
wiley   +1 more source