Results 271 to 280 of about 5,329,833 (353)

Crystallographic fragment screening against SARS‐CoV‐2 nonstructural protein 1 using the F2X‐Entry Screen and a newly developed fragment library

Acta Crystallographica Section D, EarlyView.
Two crystallographic fragment screening campaigns against SARS‐CoV‐2 nonstructural protein 1 resulted in the identification of 21 new hits.Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) continues to threaten global health. This underpins the need for novel therapeutics against this virus.
Frank Lennartz, Jan Wollenhaupt, Melanie Oelker, Paula Fröling, Uwe Mueller, Anke Deckers, Christoph Grathwol, Stefan Bräse, Nicole Jung, Manfred S. Weiss   +9 more
wiley   +1 more source

In Vitro Exposure to Vaped Tetrahydrocannabinol Increases <i>Candida albicans</i> (SC5314) Growth, Metabolic Activity, Biofilm Formation, and the Expression of Virulence Genes. [PDF]

Microorganisms
Laaboudi FZ, Amri O, Rouabhia M.
europepmc   +1 more source

Role of Antimicrobial Peptides in the Pathogenesis of Atopic Dermatitis

The Journal of Dermatology, EarlyView.
ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by barrier dysfunction, immune dysregulation, and microbial dysbiosis. Recent studies have highlighted the multifaceted roles of antimicrobial peptides (AMPs) both as innate defenders against microbial invasion and as regulators of immune responses and skin barrier ...
Ge Peng, Alafate Abudouwanli, Quan Sun, Yi Tan, Wanchen Zhao, Mengyao Yang, Shan Wang, Hideoki Ogawa, Ko Okumura, François Niyonsaba   +9 more
wiley   +1 more source

Phage-mediated horizontal transfer of <i>Salmonella enterica</i> virulence genes with regulatory feedback from the host. [PDF]

Imeta
She T, Tan D, Balcazar JL, Friman VP, Wang D, Zhu D, Ye M, Sun M, Yuan S, Hu F.   +9 more
europepmc   +1 more source

Russian wheat aphid: a model for genomic plasticity and a challenge to breeders

Insect Science, EarlyView.
Invasive foundress finds suitable habitat and reproduces through pathogenesis. Wingless females produce life offspring quickly, which leads to high population densities. High population densities result in competition, which may induce epigenetic changes and wing development for dispersal.
Astrid Jankielsohn, Vicky L. Tolmay, Marlon‐Schylor Luke le Roux, Lintle Mohase, Mpho S. Mafa, Vittorio F. Nicolis, Eduard Venter, Nicolaas Francois Visser Burger, Anna‐Maria Botha   +8 more
wiley   +1 more source

The role of virulence genes in <i>Campylobacter</i> pathogenicity: a perspective from the Gulf Cooperation Council countries. [PDF]

Front Cell Infect Microbiol
Mohamed MI, Khalifa HO, Habib I.
europepmc   +1 more source

Genomic features of the Helicobacter pylori strain PMSS1 and its virulence attributes as deduced from its in vivo colonisation patterns

, 2018
Alikhan, Arnold, Aspholm, Aziz, Backert, Backert, Bankevich, Barrozo, Bartfeld, Bauer, Belogolova, Bonsor, Cao, Censini, Deguchi, Dixon, Draper, Farnbacher, Fischer, Gall, Gaudet, Gomez-Duarte, Gressmann, Higashi, Ishijima, Israel, Jang, Javaheri, Koch, Kusters, Königer, Lai, Lee, Lind, Linz, Lowenthal, Odenbreit, Olbermann, Philpott, Salama, Schmitt, Stein, Talarico, Tammer, Tan, Treangen, Viala, Zimmermann   +47 more
core   +1 more source

Iflaviruses in arthropods: when small is mighty

Insect Science, EarlyView.
Many arthropod species harbor iflaviruses, which often cause covert (asymptomatic) infections, but may still affect host fitness. We review the impact of iflaviruses on arthropod fitness, immunity, behaviour as well as the iflavirus’ host range, transmission, tissue tropism and the interactions with other microorganisms within arthropods.
Annamaria Mattia, Hannah‐Isadora Huditz, Monique M. van Oers, Vera I.D. Ros   +3 more
wiley   +1 more source

Pivotal role of Helicobacter pylori virulence genes in pathogenicity and vaccine development. [PDF]

Front Med (Lausanne)
Elbehiry A, Marzouk E, Abalkhail A, Sindi W, Alzahrani Y, Alhifani S, Alshehri T, Anajirih NA, ALMutairi T, Alsaedi A, Alzaben F, Alqrni A, Draz A, Almuzaini AM, Aljarallah SN, Almujaidel A, Abu-Okail A.   +16 more
europepmc   +1 more source

Comparison of Three Sympatric Desert Lizards: Digestive Tract Structure, Digestive Enzyme Activities, Gut Microbiota, and Metabolites

Integrative Zoology, EarlyView.
We performed 16S rDNA sequencing and metabolite profiling for three sympatric lizard species—Teratoscincus roborowskii, Phrynocephalus axillaris, and Eremias roborowskii—and compared their goblet cell and enzyme activities in the digestive tract. Our study suggests that the dietary niche may promote divergence or convergence of microbiota across host ...
Yi Yang, Ziyi Wang, Ruichen Wu
wiley   +1 more source