Plasmid-mediated virulence in Chlamydia [PDF]
Frontiers in Cellular and Infection Microbiology, 2023 Chlamydia trachomatis infection of ocular conjunctiva can lead to blindness, while infection of the female genital tract can lead to chronic pelvic pain, ectopic pregnancy, and/or infertility.
Catherine O'Connell, Toni Darville
exaly +8 more sources
Co-conjugation of Virulence Plasmid and KPC Plasmid in a Clinical Klebsiella pneumoniae Strain [PDF]
Frontiers in Microbiology, 2021 Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-HvKP) strains have been increasingly reported, and it is important to understand the evolutionary mechanisms of these highly pathogenic and resistant bacterial pathogens.
Ning Dong, Rong Zhang, Lianwei Ye
exaly +4 more sources
RES-Xre toxin-antitoxin locus knaAT maintains the stability of the virulence plasmid in Klebsiella pneumoniae [PDF]
Emerging Microbes and InfectionsHypervirulent Klebsiella pneumoniae isolates have been increasingly reported worldwide, especially hypervirulent drug-resistant variants owing to the acquisition of a mobilizable virulence plasmid by a carbapenem-resistant strain.
Yongkui Chen +7 more
doaj +3 more sources
Genetic characterization and passage instability of a novel hybrid virulence plasmid in a ST23 hypervirulent Klebsiella pneumoniae [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 Hypervirulent variants of Klebsiella pnuemoniae (hvKP), which causes life-threatening infections, is a global priority pathogen and frequently harbours virulence plasmids. The virulence plasmids have emerged as the predominant vehicles carrying the major
Lin-Ping Fan +13 more
doaj +2 more sources
Genetic and Functional Characterization of a Conjugative KpVP-2-Type Virulence Plasmid From a Clinical Klebsiella pneumoniae Strain [PDF]
Frontiers in Microbiology, 2022 The main mechanism of virulence in Klebsiella pneumoniae is the acquisition of K. pneumoniae virulence plasmids (KpVPs), which include two dominant types, namely, KpVP-1 (carrying iuc1, iro1, rmpA, and rmpA2) and KpVP-2 (carrying iuc2, iro2, and rmpA ...
Xuemei Yang +6 more
doaj +2 more sources
A ParDE toxin–antitoxin system is responsible for the maintenance of the Yersinia virulence plasmid but not for type III secretion-associated growth inhibition [PDF]
Frontiers in Cellular and Infection Microbiology, 2023 Many Gram-negative pathogens utilize the type III secretion system (T3SS) to translocate virulence-promoting effector proteins into eukaryotic host cells.
Saskia Schott +5 more
doaj +2 more sources
Mobilization of the nonconjugative virulence plasmid from hypervirulent Klebsiella pneumoniae [PDF]
Genome Medicine, 2021 Background Klebsiella pneumoniae, as a global priority pathogen, is well known for its capability of acquiring mobile genetic elements that carry resistance and/or virulence genes.
Yanping Xu +10 more
doaj +2 more sources
Genomic evolution and dissemination of non-conjugative virulence plasmid of ST65 carbapenem-resistant and hypervirulent Klebsiella pneumoniae strains in a Chinese hospital [PDF]
Frontiers in Cellular and Infection MicrobiologyBackgroundThe global rise in infections caused by hypervirulent and carbapenem-resistant K. pneumoniae (CR-hvKp) represents a growing public health threat.
Dongxing Tian +6 more
doaj +2 more sources
Prevalence of Carbapenem-Resistant Klebsiella pneumoniae Co-Harboring blaKPC-Carrying Plasmid and pLVPK-Like Virulence Plasmid in Bloodstream Infections [PDF]
Frontiers in Cellular and Infection Microbiology, 2021 This study aimed to characterize carbapenem-resistant Klebsiella pneumoniae (CR-KP) co-harboring blaKPC-2-carrying plasmid and pLVPK-like virulence plasmid.
Fang-ling Du +8 more
doaj +2 more sources
The polyadenylase PAPI is required for virulence plasmid maintenance in pathogenic bacteria. [PDF]
PLoS PathogensMany species of pathogenic bacteria harbor critical plasmid-encoded virulence factors, and yet the regulation of plasmid replication is often poorly understood despite playing a key role in plasmid-encoded gene expression.
Katherine Schubert +17 more
doaj +2 more sources