Results 41 to 50 of about 104,714 (231)

Hybrid Plasmids Encoding Antimicrobial Resistance and Virulence Traits Among Hypervirulent Klebsiella pneumoniae ST2096 in India

Frontiers in Cellular and Infection Microbiology, 2022
BackgroundHypervirulent variants of Klebsiella pneumoniae (HvKp) were typically associated with a broadly antimicrobial susceptible clone of sequence type (ST) 23 at the time of its emergence.
Chaitra Shankar, Karthick Vasudevan, Jobin John Jacob, Stephen Baker, Barney J. Isaac, Ayyan Raj Neeravi, Dhiviya Prabaa Muthuirulandi Sethuvel, Biju George, Balaji Veeraraghavan   +8 more
doaj   +1 more source

Acquisition of a novel conjugative multidrug‐resistant hypervirulent plasmid leads to hypervirulence in clinical carbapenem‐resistant Klebsiella pneumoniae strains

mLife, 2023
The co‐occurrence of plasmid‐mediated multidrug resistance and hypervirulence in epidemic carbapenem‐resistant Klebsiella pneumoniae has emerged as a global public health issue. In this study, an ST23 carbapenem‐resistant hypervirulent K.
Gong Li, Ling Jia, Lei Wan, Lijuan Xia, Ang Gao, Runshi Yang, Ruanyang Sun, Minge Wang, Juan Du, Xinlei Lian, Rongmin Zhang, Liangxing Fang, Xiaoping Liao, Yahong Liu, Bao‐Tao Liu, Jian Sun   +15 more
doaj   +1 more source

The dynamic evolution and IS26-mediated interspecies transfer of a blaNDM-1-bearing fusion plasmid leading to a hypervirulent carbapenem-resistant Klebsiella pneumoniae strain harbouring blaKPC-2 in a single patient

Journal of Global Antimicrobial Resistance, 2023
: Objectives: To characterize the evolution and interspecies transfer of plasmids between Klebsiella pneumoniae and Escherichia coli within a single patient.
Yapei Zhang, Xuebin Tian, Fanghua Fan, Xuan Wang, Shilei Dong   +4 more
doaj   +1 more source

A hybrid plasmid formed by recombination of a virulence plasmid and a resistance plasmid in Klebsiella pneumoniae

Journal of Global Antimicrobial Resistance, 2020
The emergence of multidrug-resistant (MDR) and hypervirulent Klebsiella pneumoniae (hvKP) facilitates simultaneous dissemination of virulence and resistance in a single event, which poses serious threat to public health.This study characterized the multidrug-resistant and moderately virulent ST11 K64 K.
Xie, MM, Dong, N, Chen, KC, Yang, XM, Ye, LW, Chan, EWC, Zhang, R, Chen, S   +7 more
openaire   +4 more sources

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Virulence Plasmids of Spore-Forming Bacteria

Microbiology Spectrum, 2014
ABSTRACT Plasmid-encoded virulence factors are important in the pathogenesis of diseases caused by spore-forming bacteria. Unlike many other bacteria, the most common virulence factors encoded by plasmids in Clostridium and Bacillus species are protein toxins ...
Adams, Vicki, Li, Jihong, Wisniewski, Jessica A, Uzal, Francisco A, Moore, Robert J, McClane, Bruce A, Rood, Julian I   +6 more
openaire   +4 more sources

A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase

Advanced Science, EarlyView.
Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol, Lihi Gur‐Arie, Netanel Tzarum, Tamara Wellins, Naama Katsowich, Miriam Ravins, Michal Bejerano‐Sagie, Klil Cohen, Oded Livnah, Joshua N. Adkins, Ernesto Nakayasu, Alexei Savchenko, Yeu Khai Choong, Nikhil Kumar Tulsian, Saturo Machida, Sigal Ben‐Yehuda, Yael Litvak, J. Sivaraman, Ilan Rosenshine   +18 more
wiley   +1 more source

Pathogenomics of the Virulence Plasmids of Escherichia coli [PDF]

Microbiology and Molecular Biology Reviews, 2009
SUMMARYBacterial plasmids are self-replicating, extrachromosomal elements that are key agents of change in microbial populations. They promote the dissemination of a variety of traits, including virulence, enhanced fitness, resistance to antimicrobial agents, and metabolism of rare substances.Escherichia coli, perhaps the most studied of microorganisms,
Johnson, Timothy, Nolan, Lisa
openaire   +4 more sources

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

Cytokine profile in in vitro mouse macrophage culture infected with Bacillus anthracis spores with varying plasmid composition

Инфекция и иммунитет, 2022
Bacillus anthracis, the causative agent of anthrax, is able to exist both in environmental conditions (soil) and in the macroorganism. The manifestation of pathogenic properties of B.
Elena A. Koteneva, O. I. Tsygankova, V. Yu. Shcherbakova, A. V. Kalinin, I. S. Rodionov, V. V. Serdyukov, A. V. Abramovich, A. N. Kulichenko   +7 more
doaj   +1 more source