Results 41 to 50 of about 5,037,505 (267)

Targeting Toxoplasma gondii CPSF3 as a new approach to control toxoplasmosis

EMBO Molecular Medicine, 2017
Toxoplasma gondii is an important food and waterborne pathogen causing toxoplasmosis, a potentially severe disease in immunocompromised or congenitally infected humans.
Andrés Palencia, Alexandre Bougdour, Marie‐Pierre Brenier‐Pinchart, Bastien Touquet, Rose‐Laurence Bertini, Cristina Sensi, Gabrielle Gay, Julien Vollaire, Véronique Josserand, Eric Easom, Yvonne R Freund, Hervé Pelloux, Philip J Rosenthal, Stephen Cusack, Mohamed‐Ali Hakimi   +14 more
doaj   +1 more source

Structure of the Pds5-Scc1 Complex and Implications for Cohesin Function

Cell Reports, 2016
Sister chromatid cohesion is a fundamental prerequisite to faithful genome segregation. Cohesion is precisely regulated by accessory factors that modulate the stability with which the cohesin complex embraces chromosomes.
Kyle W. Muir, Marc Kschonsak, Yan Li, Jutta Metz, Christian H. Haering, Daniel Panne   +5 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

The influence of viral RNA secondary structure on interactions with innate host cell defences [PDF]

, 2013
RNA viruses infecting vertebrates differ fundamentally in their ability to establish persistent infections with markedly different patterns of transmission, disease mechanisms and evolutionary relationships with their hosts.
Blundell, Richard, Richard Blundell, Nora McFadden, Joris J. Maarleveld, Maarleveld, Joris J, Evans, David J, Simmonds, Peter, Jeroen Witteveldt, Maarleveld, Joris J., David J. Evans, McFadden, Nora, Peter Simmonds, Evans, David J., Witteveldt, Jeroen   +13 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

A virulent strain of deformed wing virus (DWV) of honeybees (Apis mellifera) prevails after varroa destructor-mediated, or in vitro, transmission [PDF]

, 2014
The globally distributed ectoparasite Varroa destructor is a vector for viral pathogens of the Western honeybee (Apis mellifera), in particular the Iflavirus Deformed Wing Virus (DWV).
James C Bull, Jonathan D. Moore (262014), Fannon, Jessica, Jonathan D. Moore, Dave Ch, Graham R Wood, James C. Bull¤a, Fannon, Jessica M., Jessica M Fannon, Mead, Andrew, Jessica M. Fannon (589359), James C. Bull (107677), Nigel Burroughs (589360), David J. Evans (208308), Graham R. Wood, Nigel Burroughs, David J. Evans, Ryabov, Eugene V., Wood, Graham R., Chandler, Dave, Eugene V. Ryabov (107680), Mead, A. (Andrew), Eugene V Ryabov, Andrew Mead, David J Evans, Jonathan D Moore, Moore, Jonathan D., Wood, Graham, Bull, James C., Burroughs, Nigel, Graham R. Wood (589358), Dave Chandler (107700), Dave Chandler, Jessica M. Fannon, Andrew Mead (107686), Bull, James C. (James Christopher), Burroughs, Nigel John, Evans, David J., Eugene V. Ryabov   +38 more
core   +2 more sources

Identification of a culturable fungal species and endosymbiotic bacteria in saliva of Aedes aegypti and Culex pipiens and their impact on arbovirus infection in vitro

Parasites & Vectors
Background Mosquito saliva plays a key role in arbovirus transmission and pathogenesis. It was shown that saliva contains several molecules that are essential for blood feeding.
Lanjiao Wang, Laure Remue, Nikki Adriaens, Alina Soto, Sam Verwimp, Joyce van Bree, Katrien Trappeniers, Leen Delang   +7 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Heterogeneous host susceptibility enhances prevalence of mixed-genotype micro-parasite infections [PDF]

, 2011
Dose response in micro-parasite infections is usually shallower than predicted by the independent action model, which assumes that each infectious unit has a probability of infection that is independent of the presence of other infectious units. Moreover,
Zwart, Mark P., Lia Hemerik, Hemerik, L., Just M. Vlak, Mark P. Zwart, Mark P Zwart, Vlak, J.M., van der Werf, Wopke, van der Werf Wopke, Hemerik, Lia, Just M Vlak, Hemerik Lia, Vlak Just M., Zwart Mark P., Zwart, M.P., Wopke van der Werf, Vlak, Just M., Werf, W., van der, van der Werf, W.   +18 more
core   +2 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source