Results 31 to 40 of about 253,847 (119)

RBM39 shapes innate immunity by controlling the expression of key factors of the interferon response

Frontiers in Immunology
Background and aimsThe contribution of innate immunity to clearance of viral infections of the liver, in particular sensing via Toll-like receptor 3 (TLR3), is incompletely understood. We aimed to identify the factors contributing to the TLR3 response in
Teng-Feng Li, Paul Rothhaar, Arthur Lang, Oliver Grünvogel, Ombretta Colasanti, Santa Mariela Olivera Ugarte, Jannik Traut, Antonio Piras, Nelson Acosta-Rivero, Vladimir Gonçalves Magalhães, Emely Springer, Andreas Betz, Hao-En Huang, Jeongbin Park, Jeongbin Park, Jeongbin Park, Ruiyue Qiu, Gnimah Eva Gnouamozi, Ann-Kathrin Mehnert, Viet Loan Dao Thi, Viet Loan Dao Thi, Stephan Urban, Stephan Urban, Martina Muckenthaler, Matthias Schlesner, Matthias Schlesner, Dirk Wohlleber, Marco Binder, Ralf Bartenschlager, Ralf Bartenschlager, Ralf Bartenschlager, Andreas Pichlmair, Andreas Pichlmair, Volker Lohmann, Volker Lohmann   +34 more
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Structural characterization of antibiotic self-immunity tRNA synthetase in plant tumour biocontrol agent

Nature Communications, 2016
The bacterium Agrobacterium radiobacter K84 secretes an antibiotic that is transported into the plant pathogen A. tumefaciensand processed into the toxin TM84.
Shaileja Chopra, Andrés Palencia, Cornelia Virus, Sarah Schulwitz, Brenda R. Temple, Stephen Cusack, John Reader   +6 more
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Tobacco mosaic virus Induced Alterations in the Gene Expression Profile of Arabidopsis thaliana

Molecular Plant-Microbe Interactions, 2003
In this study, mRNA profiles generated from cDNA microarrays were used to identify gene expression changes in Arabidopsis thaliana ecotype Shahdara infected with Tobacco mosaic virus (TMV).
Sheetal Golem, James N. Culver
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Redefining the immune landscape of hepatitis A virus infection

Experimental and Molecular Medicine
Despite the development of effective vaccines against hepatitis A virus (HAV) infection, outbreaks of acute hepatitis A still occur globally, such that HAV remains a major cause of acute viral hepatitis.
Ombretta Colasanti, Hosun Yu, Volker Lohmann, Eui-Cheol Shin   +3 more
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Transcriptional profiling of zebrafish intestines identifies macrophages as host cells for human norovirus infection

Gut Microbes
Human noroviruses (HuNoVs) are a major cause of diarrheal disease, yet critical aspects of their biology, including cellular tropism, remain unclear.
Emma Roux, Reegan J. Willms, Jana Van Dycke, Álvaro Cortes Calabuig, Lore Van Espen, Geert Schoofs, Jelle Matthijnssens, Johan Neyts, Peter de Witte, Edan Foley, Joana Rocha-Pereira   +10 more
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SARS-CoV-2 entry and fusion are independent of ACE2 localization to lipid rafts

Journal of Virology
Membrane fusion occurs at the early stages of SARS-CoV-2 replication, during entry of the virus, and later during the formation of multinucleated cells called syncytia.
William Bolland, Inès Marechal, Chloé Petiot, Françoise Porrot, Florence Guivel-Benhassine, Anne Brelot, Nicoletta Casartelli, Olivier Schwartz, Julian Buchrieser   +8 more
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Highly replicating hepatitis C virus variants emerge in immunosuppressed patients causing severe disease

Nature Communications
Hepatitis C virus (HCV) exists as a heterogenous quasispecies, but the phenotypic consequences of viral variability are widely unexplored. Here we identify a replication enhancing domain (ReED) in non-structural protein 5A conferring high replication ...
Paul Rothhaar, Tomke Arand, Ha Gyu-Thomas Seong, Christian Heuss, Margaret Tulessin, Zhiqing Wang, Colin Förster, Alina C. Schneider, Jocelyn Quistrebert, Haiting Chai, Marvin Reineke, Louise Benning, Jonathan Honegger, Maike Hofmann, Robert Thimme, Jörg Timm, STOPHCV investigators, Paul Schnitzler, Uta Merle, Naglaa H. Shoukry, Julie Bruneau, Chaturaka Rodrigo, Andrew Lloyd, Rowena A. Bull, M. Azim Ansari, Carolin Mogler, John McLauchlan, Xavier Forns, Sofía Pérez-del-Pulgar, Volker Lohmann   +29 more
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Uncovering Virus-Virus Interactions by Unifying Approaches and Harnessing High-Throughput Tools

mSystems, 2019
Virus-host interactions have received much attention in virology. Virus-virus interactions can occur when >1 virus infects a host and can be deemed social when one virus affects the fitness of another virus, as in the well-known case of superinfection ...
Samuel L. Díaz-Muñoz
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A single mutation in the PrM gene of Zika virus determines AXL dependency for infection of human neural cells

Journal of Virology
Zika virus (ZIKV) is spread by mosquito bites and is unique among known flaviviruses for being able to cause microcephaly. Entry factors for ZIKV are incompletely understood, but phosphatidylserine (PS) receptors, including the TAM (Tyro3, AXL, and Mer ...
Renu Khasa, Sarah C. Ogden, Yuqing Wang, Zongiun Mou, Anna D. Metzler, Xuping Xie, Xinghong Dai, Hengli Tang   +7 more
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Alignment of virus-host protein-protein interaction networks by integer linear programming: SARS-CoV-2.

PLoS ONE, 2020
MotivationBeside socio-economic issues, coronavirus pandemic COVID-19, the infectious disease caused by the newly discovered coronavirus SARS-CoV-2, has caused a deep impact in the scientific community, that has considerably increased its effort to ...
Mercè Llabrés, Gabriel Valiente
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