Results 101 to 110 of about 10,857,229 (262)

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Hepatitis C virus infection epidemiology among people who inject drugs in Europe: a systematic review of data for scaling up treatment and prevention. [PDF]

, 2014
BACKGROUND: People who inject drugs (PWID) are a key population affected by hepatitis C virus (HCV). Treatment options are improving and may enhance prevention; however access for PWID may be poor.
Mcdonald, B, Hope, V, Basso, M, Eramova, I, Abel-Ollo, Katri, Sperle, Ida, Michot, I, Sperle, Ide, Hatzakis Angelos, Van Houdt, Sabine, Ferri, Marica, Griffiths, Paul, Lazarus Jeffrey V., Vickerman Peter, Částková, Jitka, Rosińska, Magdalena, Tarjan, A, Maria Prins, Aleixandre, Noelia Llorens, Vivian D. Hope (605401), Klavs, I, Fouchard, Jan, Brummer-Korvenkontio, Henrikki, Grady, Bart, Matheï, Catharina, Brummer-Korvenkontio, H, Berglund, T, Kantzanou Maria, Ncube, F, Lopes, Sofia, Eramova, Irina, Struzik, M, Catharina Matheï (605402), Kostrikis, L, Abagiu, Adrian Octavian, Vickerman, P, Fouchard, J, Goldberg, David, Jauffret-Roustide, Marie, Rehak, V, Fotsiou, Nasia, Mravcik, V, Caplinskiene, Irma, Folch, Cinta, Fotiou, A, Melillo, Jackie, Kustec, T, Hobstová, Jiřina, Lazarus, JV, Lazarus, Jeffrey V., Bravo, Maria Jose, Tarján, Anna, Mathei, C, Brisacier, A-C, Prins, Maria, Demanuele, Carlo Olivari, Isabelle Giraudon, EK, Wiessing, Lucas, Fotiou, Anastasios, Martins, Helena Cortes, Nechanska, B, Hope, Vivian D., Hobstova, J, Marica Ferri (605396), Grady, B, Wiessing, L, Bollaerts, Kaat, Giraudon, Isabelle, Rosinska, M, Fotsiou, N, Bogdanova, V, Struzik, Marta, Hutchinson, Sharon, Cullen, Katelyn J., Wiessing Lucas, Ruta, S, Kustec, Tanja, Catharina Matheï, Vilar, G, Hutchinson, S, Bogdanova, Violeta, Croes, Esther, Op De Coul, Eline, Ida Sperle (605399), Origer, A, Michot, Isabelle, Klavs, Irena, Palladino, C, Angelos Hatzakis (146074), Hatzakis, Angelos, Peter Vickerman, Nesheva, E, Katelyn J Cullen, Lazarus, Jeffrey V, Camilleri, M, Tallo, Tatjana, Brisacier, Anne Claire, Hope Vivian D., Martins, HC, Bollaerts, K, Hope, Vivian D, Goldberg, D, Cullen, KJ, Prins, M, Maria Prins (339491), Gómez, Rosario Sendino, Platt, Lucy, Kantzanou, Maria, EMCDDA DRID group, Hotho, Daphne, Van Houdt, S, Martins, M, Cullen, Katelyn J, Low, Andrea, Thornton, Lelia, Hutchinson, Sharon; id_orcid, Prins Maria, Palladino, Claudia, Tefanova, Valentina, Resende, Maria Emília, Resende, E, Marica Ferri, Kalamara, Eleni, Galvin, B, Karnite, A, Gomez, RS, Zimmermann, R, Ferri, M, Strandberg, J, Bart Grady (605397), Tallo, T, Busch, M, Folch, C, Gazdag, Gábor, Strandberg, Joakim, Jeffrey V Lazarus, Maria Kantzanou (605398), Jeffrey V. Lazarus (250583), Grady Bart, Abel-Ollo, K, Mcdonald, Bethan, Nechanská, Blanka, Lopes, S, Castkova, J, Maria Kantzanou, Ferri Marica, Kopilovic, B, Ruta, Simona, Vivian D. Hope, Gazdag, G, Duran, Domingos, Galvin, Brian, Groshkova, Teodora, Arama, V, Caplinskiene, I, Jeffrey V. Lazarus, Ida Sperle, Kantzanou, M, Croes, E, Garavan, C, Busch, Martin, Cruciani, Mario, Berglund, Torsten, Origer, Alain, Vilar, Graça, Melillo, J, Kopilovic, Boris, Řehák, Vratislav, Hope, VD, Cullen Katelyn J., Low, A, Matheï Catharina, Martins, Mário, Vicente, J, Angelos Hatzakis, Sperle, I, Nesheva, Elmira, Mravčík, Viktor, Platt, L, Demanuele, CO, Ncube, Fortune, Cruciani, M, Zimmermann, Ruth, Tefanova, V, Lucas Wiessing (483360), Lucas Wiessing, Thornton, L, Aleixandre, NL, Groshkova, T, Arama, Victoria, Bravo, MJ, Katelyn J. Cullen (605400), Jauffret-Roustide, M, Abagiu, AO, Sperle Ida, Op de Coul, E, Vivian D Hope, Duran, D, Kostrikis, Leontios, Karnite, Anda, Hotho, D, Yury E. Khudyakov, Bart Grady, Vickerman, Peter, BASSO, MONICA, Griffiths, P, Vicente, Julian, Peter Vickerman (210007), Katelyn J. Cullen, Hatzakis, A, Camilleri, Moses   +210 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Prevalence of Hepatitis B Virus (HBV) infection among Iranian prisoners during 2001-2005

Payesh, 2008
Objective(s): To determine the prevalence of Hepatitis B Virus (HBV) infection, as a blood borne viral infection, among prisoners and its associated factors in Iran.Methods: In this cross sectional study, 5317 inmates, who had stayed in prison for at ...
Mohammad K., Asgari F., Goya M.M., Fotouhi A., Yousefi A.   +4 more
doaj  

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source