Results 111 to 120 of about 421,443 (284)

Entry pathways of herpes simplex virus type 1 into human keratinocytes are dynamin- and cholesterol-dependent [PDF]

, 2011
Herpes simplex virus type 1 (HSV-1) can enter cells via endocytic pathways or direct fusion at the plasma membrane depending on the cell line and receptor(s).
Mei-Ju Hsu, Frazer J. Rixon, Petermann, P., Rixon Frazer J., Rahn, E., Hsu Mei-Ju, Knebel-Mörsdorf, D., Geraghty, R.J., Dagmar Knebel-Mörsdorf, Rahn Elena, Philipp Petermann, Knebel-Mörsdorf Dagmar, Elena Rahn, Frazer J Rixon, Hsu, M.-J., Rixon, F.J., Petermann Philipp   +16 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Association between harm reduction intervention uptake and recent hepatitis C infection among people who inject drugs attending sites that provide sterile injecting equipment in Scotland

, 2012
Prevalence of the hepatitis C virus (HCV) among people who inject drugs (PWID) in Scotland is high. The Scottish Government has invested significantly in harm reduction interventions with the goal of reducing HCV transmission among PWID.
Hutchinson, Sharon, Palmateer, Norah Elizabeth, Hutchinson, Sharon; id_orcid, Goldberg, David J., Taylor, Avril, Cameron, Sheila O., Palmateer, Norah; id_orcid, Allen, Elizabeth A.   +7 more
core   +1 more source

Genetic variation in the interleukin-28B gene is associated with spontaneous clearance and progression of hepatitis C virus in Moroccan patients [PDF]

, 2013
Genetic variation in the IL28B gene has been strongly associated with treatment outcomes, spontaneous clearance and progression of the hepatitis C virus infection (HCV).
Alaoui, Rihmou, Diepolder H., Salwa Nadir, Helmut Diepolder, Thursz, Mark, Sayeh Ezzikouri (143566), Khakoo Salim I., Mark Thursz, Soumaya Benjelloun (143569), Alaoui R., Alaoui Rhimou, Khakoo, Salim I., Mark Thursz (276871), Helmut Diepolder (276870), Nadir S., Ezzikouri Sayeh, Rebbani K., Nadir Salwa, Fakhir Fatima-Zohra, Fakhir F.-Z., Benjelloun, Soumaya, Benjelloun S., Fatima-Zohra Fakhir, Salim I Khakoo, Diepolder, Helmut, Thursz Mark, Nadir, Salwa, Benjelloun Soumaya, Brahim Ikram, Rhimou Alaoui, Rhimou Alaoui (276865), Brahim I., Diepolder, Helmut M., Sayeh Ezzikouri, Rebbani Khadija, Ikram Brahim, Alaoui, Rhimou, Rebbani, Khadija, Fatima-Zohra Fakhir (276868), Soumaya Benjelloun, Khadija Rebbani, Ikram Brahim (276867), Ezzikouri S., Salwa Nadir (276869), Khakoo S.I., Thursz M., Diepolder Helmut, Khadija Rebbani (276866), Salim I. Khakoo (201172), Fakhir, Fatima-Zohra, Ezzikouri, Sayeh, Brahim, Ikram   +51 more
core   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

The extreme C terminus of herpes simplex virus DNA polymerase is crucial for functional interaction with processivity factor UL42 and for viral replication

, 1993
The herpes simplex virus DNA polymerase is composed of two subunits, a large catalytic subunit (Pol) and a smaller subunit (UL42) that increases the processivity of the holoenzyme.
Bebrin, William R, Paul Digard, M. Coen, Digard, Paul, Weisshart, Klaus, Klaus Weisshart, Coen, Donald M, William R. Bebrin, Donald   +8 more
core  

The potato mop-top virus TGB2 protein and viral RNA associate with chloroplasts and viral infection induces inclusions in the plastids [PDF]

, 2012
The potato mop-top virus (PMTV) triple gene block 2 (TGB2) movement proteins fused to monomeric red fluorescent protein (mRFP-TGB2) was expressed under the control of the PMTV subgenomic promoter from a PMTV vector.
Roberts, Alison G., Cowan, Graham H., Angelika eZiegler, Ziegler, Angelika, Eugene I Savenkov, Lesley eTorrance, Angelika Ziegler, Lesley Torrance, Alison G Roberts, Torrance, Lesley, Sean N. Chapman, Graham H Cowan, Chapman, Sean N., Savenkov, Eugene I., Sean N Chapman, Alison G. Roberts, Chapman, Sean, Graham H. Cowan, Eugene I. Savenkov, Savenkov, Eugene   +19 more
core   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Human immunodeficiency virus-specific gamma interferon enzyme-linked immunospot assay responses targeting specific regions of the proteome during primary subtype C infection are poor predictors of the course of viremia and set point. [PDF]

, 2008
It is unknown whether patterns of human immunodeficiency virus (HIV)-specific T-cell responses during acute infection may influence the viral set point and the course of disease. We wished to establish whether the magnitude and breadth of HIV type 1 (HIV-
Gray, Clive M, van Loggerenberg, Francois, Mlotshwa, Mandla., Mathebula, Tiyani, Seoighe, Cathal., Morris, Lynn, Ngandu, Nobubelo K., Morris, Lynn., Mlisana, Koleka Patience., CAPRISA 002 Acute Infection Study Team, Gray, Clive M., Mlisana, Koleka, Riou, Catherine, Abdool Karim, Salim Safurdeen., Williamson, Carolyn., Mathebula, Tiyani., de Assis Rosa, Debra, Seoighe, Cathal, Mashishi, Tumelo., Mashishi, Tumelo, Williamson, Carolyn, Karim, Salim Abdool, de Assis Rosa, Debra., Ngandu, Nobubelo, Riou, Catherine., van Loggerenberg, Francois., Mlotshwa, Mandla   +26 more
core   +1 more source

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source