Results 71 to 80 of about 10,857,229 (262)

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Seroprevalence of hepatitis B markers among incarcerated intravenous drug users

Journal of Research in Medical Sciences, 2014
Background: Drug injection is one of the most prominent risk factors for transmission of viral hepatitis. Prevalence of hepatitis B virus (HBV) is generally higher in prisoners compared with the general population.
Zary Nokhodian, Majid Yaran, Peyman Adibi, Nazila Kassaian, Marjan Meshkati, Behrooz Ataei   +5 more
doaj  

Erythromycin Estolate Inhibits Zika Virus Infection by Blocking Viral Entry as a Viral Inactivator

Viruses, 2019
Recently, Zika virus (ZIKV) has attracted much attention in consideration of its association with severe neurological complications including fetal microcephaly.
Xiaohuan Wang, Shuai Xia, Peng Zou, Lu Lu   +3 more
doaj   +1 more source

Prevalence of human immunodeficiency virus drug resistance and factors associated with high viral load among adolescents on antiretroviral therapy in Dar Es Salaam, Tanzania

HIV Research & Clinical Practice
Resistance to antiretrovirals against human immunodeficiency virus (HIV) poses a threat to zero transmission of HIV by 2030. Few studies have been conducted on HIV drug resistance (HIVDR) mutations targeting adolescents. We determined the prevalence, pattern of HIVDR mutations, and factors associated with unsuppressed HIV viral load among adolescents ...
Irene Maseke, Agricola Joachim, Doreen Kamori, Ahmed Abade, Nyambura Moremi, Mtebe Majigo   +5 more
openaire   +3 more sources

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Association between non-injection drug use and hepatitis C infection among HIV-negative men who have sex with men

BMC Infectious Diseases
Background Prior research predominantly examined the association between HIV-positive men who have sex with men (MSM) or those using injection drugs and hepatitis C virus (HCV) infection.
Jing Zhao, Charles Green, Christine Markham, Kayo Fujimoto, Alan G. Nyitray, Lu-Yu Hwang   +5 more
doaj   +1 more source

Drug resistance mutations in drug-naive HIV type 1 subtype C-infected individuals from rural Malawi. [PDF]

, 2010
In this preliminary study we show that in 2008, 3 years after antiretroviral therapy was introduced into the Karonga District, Malawi, a greater than expected number of drug-naive individuals have been infected with HIV-1 subtype C virus harboring major ...
Grace P. McCormack, Emmanuel Banda, Judith R. Glynn, Bansode, Vijay, McCormack, Grace P., Glynn, Judith R., Neil French, French, Neil, Glynn, Judith R, Zuzanna J. Drebert, Banda, Emmanuel, Drebert, Zuzanna J., Molesworth, Anna, Vijay Bansode, Travers, Simon AA, Amelia Crampin, Drebert, Zuzanna, McCormack, Grace P, Crampin, Amelia, Anna Molesworth, Drebert, Zuzanna J, Simon A.A. Travers, Travers, Simon A A, Travers, Simon A.A., Ngwira, Bagrey, Bagrey Ngwira   +25 more
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Incidence of Hepatitis B and HIV Virus at Cadaver of IV Drug Abusers in Tehran [PDF]

Injection drug use has been the most growing rout of drug abuse in Iran in the past decade and it has been responsible for the transmission of HIV virus in more than two third of cases.
اخلاقی, میترا, توفیقی زواره, حسن, قربانی, مظاهر, مصطفی زاده, بابک, محقق, علیرضا, یغمائی, اسدلله, فرزانه, اسماعیل   +6 more
core