Results 71 to 80 of about 421,443 (284)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

M. tuberculosis genotypic diversity and drug susceptibility pattern in HIV-infected and non-HIV-infected patients in northern Tanzania. [PDF]

, 2007
Contains fulltext : 53004.pdf (Publisher’s version ) (Open Access)BACKGROUND: Tuberculosis (TB) is a major health problem and HIV is the major cause of the increase in TB.
Boeree, M.J., Sola Christophe, Martin Boeree, Kibiki, Gibson S, Mulder, Bert, van Soolingen Dick, Jessica L de Beer, de Beer Jessica L, Bert Mulder, Dolmans, Wil M V, Mulder, B., Boeree Martin, Christophe Sola, van der Zanden, Adri G M, Dolmans Wil MV, Beer, J.L. de, Dolmans, W.M.V., Kibiki, G.S., Dick van Soolingen, Mulder Bert, Boeree, Martin, de Beer, Jessica L, Soolingen, D. van, Sam, N., Kibiki Gibson S, van der Zanden Adri GM, Noel Sam, van Soolingen, Dick, Sam Noel, Sola, Christophe, Adri GM van der Zanden, Gibson S Kibiki, Zanden, A.G. van der, Sola, C., Wil MV Dolmans, Sam, Noel   +35 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Influenza virus sequence feature variant type analysis: evidence of a role for NS1 in influenza virus host range restriction [PDF]

, 2012
Genetic drift of influenza virus genomic sequences occurs through the combined effects of sequence alterations introduced by a low fidelity polymerase and the varying selective pressures experienced as the virus migrates through different host ...
García-Sastre, Adolfo, García-Sastre, A., Hunt, V., Squires, R Burke, Scheuermann, Richard H, Liu, Mengya, Galloway, S.E., Klem, Edward, Squires, R.B., Pickett, Brett E, Hale, B.G., Noronha, J.M., Takimoto, T., Hale, Benjamin G, Takimoto, Toru, Air, G.M., Schmolke, M., Klem, E., Liu, M., Hunt, Victoria, McGee, M., Pickett, B.E., Scheuerman, R.H., Noronha, Jyothi M, McGee, Monnie, Schmolke, Mirco, Air, Gillian M, Galloway, Summer E   +27 more
core   +1 more source

Seroprevalence of hepatitis B markers among incarcerated intravenous drug users

Journal of Research in Medical Sciences, 2014
Background: Drug injection is one of the most prominent risk factors for transmission of viral hepatitis. Prevalence of hepatitis B virus (HBV) is generally higher in prisoners compared with the general population.
Zary Nokhodian, Majid Yaran, Peyman Adibi, Nazila Kassaian, Marjan Meshkati, Behrooz Ataei   +5 more
doaj  

Erythromycin Estolate Inhibits Zika Virus Infection by Blocking Viral Entry as a Viral Inactivator

Viruses, 2019
Recently, Zika virus (ZIKV) has attracted much attention in consideration of its association with severe neurological complications including fetal microcephaly.
Xiaohuan Wang, Shuai Xia, Peng Zou, Lu Lu   +3 more
doaj   +1 more source

Prevalence of human immunodeficiency virus drug resistance and factors associated with high viral load among adolescents on antiretroviral therapy in Dar Es Salaam, Tanzania

HIV Research & Clinical Practice
Resistance to antiretrovirals against human immunodeficiency virus (HIV) poses a threat to zero transmission of HIV by 2030. Few studies have been conducted on HIV drug resistance (HIVDR) mutations targeting adolescents. We determined the prevalence, pattern of HIVDR mutations, and factors associated with unsuppressed HIV viral load among adolescents ...
Irene Maseke, Agricola Joachim, Doreen Kamori, Ahmed Abade, Nyambura Moremi, Mtebe Majigo   +5 more
openaire   +3 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Factors associated with different responses to combination antiretroviral therapy in an observational cohort study of HIV-1 infected patients [PDF]

, 2008
The introduction of combination antiretroviral therapy (cART) into clinical practice for the treatment of HIV in 1995-1996 has led to dramatic reductions in mortality and morbidity. Factors linked to a positive response to therapy include a potent and
Bannister, W.P., Bannister, W P
core  

Virus demyelination [PDF]

, 2003
A number of viruses can initiate central nervous system (CNS) diseases that include demyelination as a major feature of neuropathology. In humans, the most prominent demyelinating diseases are progressive multifocal leukoencephalopathy, caused by JC ...
Fazakerley, John K, Walker, Robert
core   +1 more source