Results 61 to 70 of about 421,443 (284)

RHIVDB: A Freely Accessible Database of HIV Amino Acid Sequences and Clinical Data of Infected Patients

Frontiers in Genetics, 2021
Human immunodeficiency virus (HIV) infection remains one of the most severe problems for humanity, particularly due to the development of HIV resistance.
Olga Tarasova, Anastasia Rudik, Dmitry Kireev, Vladimir Poroikov   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Taiwan consensus statement on the management of chronic hepatitis B

Journal of the Formosan Medical Association, 2019
The experts of Taiwan Association for the Study of Liver (TASL) have actively participated and led the guidelines on hepatitis B virus (HBV) management by Asian Pacific Association for the Study of Liver (APASL) which is the first international ...
Rong-Nan Chien, Jia-Horng Kao, Cheng-Yuan Peng, Chien-Hung Chen, Chun-Jen Liu, Yi-Hsiang Huang, Tsung-Hui Hu, Hwa-I Yang, Sheng-Nan Lu, Yen-Hsuan Ni, Won-Long Chuang, Chuan-Mo Lee, Jaw-Chin Wu, Pei-Jer Chen, Yun-Fan Liaw   +14 more
doaj   +1 more source

Standards of induced pluripotent stem cells derived clinical-grade neural stem cells preparation and quality control (2021 China version)

Journal of Neurorestoratology, 2021
Induced pluripotent stem cells (iPSCs) have become the leading research object in the clinical application of restorative medicine. They are easily generated from diverse cell sources and functionally indistinguishable from embryonic stem cells without ...
Meng Cai, Fabin Han, Nanxiang Xiong, Yihao Wang, Shiqing Feng, Jiajing Wang, Xiang Li, Jun Wei, Changkai Sun   +8 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

A significant sex--but not elective cesarean section--effect on mother-to-child transmission of hepatitis C virus infection

, 2005
BACKGROUND: Risk factors for mother-to-child transmission of hepatitis C virus (HCV) are poorly quantified. METHODS: We conducted a European multicenter prospective study of HCV-infected pregnant women and their infants.
LANARI, MARCELLO, European, Paediatric Hepatitis C. Virus Network   +1 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Plasma drug activity assay for treatment optimization in tuberculosis patients

, 2011
Item does not contain fulltextLow antituberculosis (TB) drug levels are common, but their clinical significance remains unclear, and methods of measurement are resource intensive.
Scott K. Heysell, Mpagama, S., Kibiki, Gibson S, Houpt, Eric R, Mwaigwisya, S., Heysell, Scott K, Ndusilo, Norah, Pholwat, Suporn, Mwaigwisya, Solomon, Kibiki, G.S., Solomon Mwaigwisya, Suporn Pholwat, Jean Gratz, Mtabho, C., Aarnoutse, R.E., Stellah Mpagama, Heysell, S.K., Rob E. Aarnoutse, Charles Mtabho, Gratz, J., Mpagama, Stellah, Norah Ndusilo, Gratz, Jean, Houpt, E.R., Gibson S. Kibiki, Eric R. Houpt, Mtabho, Charles, Aarnoutse, Rob E, Ndusilo, N., Pholwat, S.   +29 more
core   +1 more source

Identifying genetic determinants of complex phenotypes from whole genome sequence data

BMC Genomics, 2019
Background A critical goal in biology is to relate the phenotype to the genotype, that is, to find the genetic determinants of various traits. However, while simple monofactorial determinants are relatively easy to identify, the underpinnings of complex ...
George S. Long, Mohammed Hussen, Jonathan Dench, Stéphane Aris-Brosou   +3 more
doaj   +1 more source

Immunopathogenesis and Cellular Interactions in Human T-Cell Leukemia Virus Type 1 Associated Myelopathy/Tropical Spastic Paraparesis

Frontiers in Microbiology, 2020
HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) is a neuropathological disorder in 1–3% of individuals infected with Human T-lymphotropic virus 1 (HTLV-1). This condition is characterized by progressive spastic lower limb weakness and
Sepehr Aghajanian, Majid Teymoori-Rad, Ghazale Molaverdi, Sayed-Hamidreza Mozhgani, Sayed-Hamidreza Mozhgani   +4 more
doaj   +1 more source