Results 121 to 130 of about 6,133,142 (332)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

The TRIMendous Role of TRIMs in Virus–Host Interactions [PDF]

Vaccines, 2017
The innate antiviral response is integral in protecting the host against virus infection. Many proteins regulate these signaling pathways including ubiquitin enzymes. The ubiquitin-activating (E1), -conjugating (E2), and -ligating (E3) enzymes work together to link ubiquitin, a small protein, onto other ubiquitin molecules or target proteins to mediate
Sarah Van Tol, Adam Hage, Maria Giraldo, Preeti Bharaj, Ricardo Rajsbaum   +4 more
openaire   +3 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Generation of replication-proficient Influenza Virus NS1 point mutants with interferon-hyperinducer phenotype [PDF]

, 2014
The NS1 protein of influenza A viruses is the dedicated viral interferon (IFN)-antagonist. Viruses lacking NS1 protein expression cannot multiply in normal cells but are viable in cells deficient in their ability to produce or respond to IFN.
Fernández, Yolanda, Juan Ortín, Randall, Richard E, Richard E. Randall (190211), Killip, Marian J, Víctor J Asensio, Bengoechea, José A, Pérez-Cidoncha, M, Marian J. Killip (571160), Marian J Killip, Maite Pérez-Cidoncha (195699), Ortín, Juan, Killip, MJ, Ortín, J, Richard E Randall, Juan Ortín (5649007), Yolanda Fernández, Fernández, Y, Asensio, Víctor J, Randall, RE, José A Bengoechea, José A. Bengoechea (124595), Pérez-Cidoncha, Maite, Bengoechea, JA, Víctor J. Asensio (571161), Bengoechea, José A; id_orcid, Maite Pérez-Cidoncha, Asensio, VJ, Yolanda Fernández (268684), Bengoechea, Jose Antonio, Asensio, Víctor José, Randall, Richard E.   +31 more
core   +2 more sources

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Virus-host protein interactions in RNA viruses [PDF]

Microbes and Infection, 2010
RNA viruses exhibit small-sized genomes that only encode a limited number of viral proteins, but still establish complex networks of interactions with host cell components. Here we summarize recent reports that aim at understanding general features of RNA virus infection networks at the protein level.
Vidalain, Pierre-Olivier, Tangy, Frédéric   +1 more
openaire   +2 more sources

Virus-host interaction in the simian immunodeficiency virus-infected brain

Journal of Neurovirology, 2008
With the increased survival of human immunodeficiency virus (HIV)-infected individuals resulting from therapy, disorders in other target organs of the virus, such as the brain, are becoming more prevalent. Here the author reviews his laboratory’s work on
H. Fox
semanticscholar   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Alphavirus nsP3 as a multifunctional orchestrator of virus-host interplay

Journal of Virology
Alphaviruses can cause polyarthralgia and encephalitis and pose an escalating global health threat to humans and animals. They are transmitted to vertebrates mainly by infected mosquitoes, leading to host alternation that drives an evolutionary arms race
Ana Alice Pimenta-Pereira, Bailey Lubinski, Rafael Kroon Campos   +2 more
doaj   +1 more source

Host-virus interaction: a new role for microRNAs

Retrovirology, 2006
MicroRNAs (miRNAs) are a new class of 18–23 nucleotide long non-coding RNAs that play critical roles in a wide spectrum of biological processes. Recent reports also throw light into the role of microRNAs as critical effectors in the intricate host ...
Pillai Beena, Maiti Souvik, Hariharan Manoj, Scaria Vinod, Brahmachari Samir K   +4 more
doaj   +1 more source