Results 111 to 120 of about 6,133,142 (332)

Interaction of hepatitis C virus polymerase with host cell proteins [PDF]

, 2009
Hepatitis C virus (HCV) interacts with host cell proteins to modify cellular pathways creating a favourable environment that facilitates its replication and persistence.
Mohamed, Ahmed Attia Alli, Mohamed, Ahmed Attia Ali   +1 more
core  

Schmallenberg virus pathogenesis, tropism and interaction with the innate immune system of the host [PDF]

, 2013
Schmallenberg virus (SBV) is an emerging orthobunyavirus of ruminants associated with outbreaks of congenital malformations in aborted and stillborn animals.
Gerald Barry, Beer Martin, Kohl, Alain, Kerstin Hahn, Schnettler Esther, Alain Kohl, Glass, M., Barry Gerald, Lamm Catherine, Martin Beer, Vanessa Herder, Mcgregor, Eva, Piras, Ilaria M., Murgia, Claudio, Herder, V., Schnettler, E., Anna Janowicz, Lamm, C., Caporale Marco, Baumgärtner, Wolfgang., Shaw, Andrew, Murgia Claudio, McGregor Eva, Palmarini, Massimo, Melanie McFarlane, Janowicz, Anna, Piras, I.M., McFarlane, Melanie, Kohl Alain, Barry, Gerald, Janowicz, A., Schnettler, Esther, Claudio Murgia, McGregor, E., Piras Ilaria M., Lamm, Catherine, Beer, Martin, Eva McGregor, Hahn, K., Caporale, M., Baumgärtner, W., Catherine Lamm, Esther Schnettler, Kohl, A., Palmarini, M., Varela, M., Mandy Glass, Murgia, C., Baumgärtner Wolfgang, Mariana Varela, Janowicz Anna, Piras, Ilaria, Varela Mariana, Ilaria M Piras, Hahn, Kerstin, Shaw, A., Varela, Mariana, McFarlane Melanie, Herder Vanessa, McFarlane, M., Palmarini Massimo, Shaw Andrew, Herder, Vanessa, Wolfgang Baumgärtner, Glass, Mandy, Andrew Shaw, Baumgärtner, Wolfgang, Marco Caporale, Massimo Palmarini, Barry, G., Hahn Kerstin, Caporale, Marco, Glass Mandy   +72 more
core   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Emerging Role of LY6E in Virus–Host Interactions [PDF]

Viruses, 2019
As a canonical lymphocyte antigen-6/urokinase-type plasminogen activator receptor Ly6/uPAR family protein, lymphocyte antigen 6 complex, locus E (LY6E), plays important roles in immunological regulation, T cell physiology, and oncogenesis. Emerging evidence indicates that LY6E is also involved in the modulation of viral infection.
Jingyou Yu, Shan-Lu Liu
openaire   +3 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Noroviral P Particle: Structure, Function and Applications in Virus-Host Interaction

Virology, 2008
Noroviruses are an important cause of epidemic acute gastroenteritis and the viruses recognize human histo-blood group antigens (HBGAs) as receptors. The protruding (P) domain of noroviral capsid, the receptor binding domain, forms subviral particles in ...
M. Tan, P. Fang, Teepanis Chachiyo, M. Xia, Pengwei Huang, Z. Fang, Wen Jiang, Xi Jiang   +7 more
semanticscholar   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Human Coronaviruses: A Review of Virus–Host Interactions [PDF]

Diseases, 2016
Human coronaviruses (HCoVs) are known respiratory pathogens associated with a range of respiratory outcomes. In the past 14 years, the onset of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) have thrust HCoVs into spotlight of the research community due to their high pathogenicity in
Lim, Yvonne Xinyi, Ng, Yan Ling, Tam, James Pingkwan, Liu, Ding Xiang   +3 more
openaire   +5 more sources

A hepatitis C virus cis-acting replication element forms a long-range RNA-RNA interaction with upstream RNA sequences in NS5B [PDF]

, 2008
The genome of hepatitis C virus (HCV) contains cis-acting replication elements (CREs) comprised of RNA stem-loop structures located in both the 5' and 3' non-coding regions (NCR), and in the NS5B coding sequence.
Diviney, Sinéad, Elliot, R., Evans, David John, Evans, D., Armstrong, V, Tuplin, Andrew, Evans, D.J., Struthers, Madeleine, Struthers, M., Elliott, Richard M., Diviney, S., Tuplin, A., Armstrong, V., Struthers, M, Simmonds, Peter, Elliott, Richard Michael, Armstrong, Victoria, Tuplin, A, Evans, David J., Simmonds, P., Diviney, S, Elliott, R.M., Simmonds, P   +22 more
core   +1 more source