Results 81 to 90 of about 722,631 (394)

Toll-like receptor agonist augments virus-like particle-mediated protection from Ebola virus with transient immune activation.

PLoS ONE, 2014
Identifying safe and effective adjuvants is critical for the advanced development of protein-based vaccines. Pattern recognition receptor (PRR) agonists are increasingly being explored as potential adjuvants, but there is concern that the efficacy of ...
Karen A O Martins, Jesse T Steffens, Sean A van Tongeren, Jay B Wells, Alison A Bergeron, Samuel P Dickson, John M Dye, Andres M Salazar, Sina Bavari   +8 more
doaj   +1 more source

Neuraminidase in Virus-like Particles Contributes to the Protection against High Dose of Avian Influenza Virus Challenge Infection

Pathogens, 2021
Neuraminidase is an important target for influenza vaccination. In this study, we generated avian influenza VLPs, expressing hemagglutinin (HA), neuraminidase (NA), HA and NA co-expressed (HANA), to evaluate the protective role of NA against a high ...
Hae-Ji Kang, Ki-Back Chu, Keon-Woong Yoon, Gi-Deok Eom, Jie Mao, Min-Ju Kim, Su-Hwa Lee, Eun-Kyung Moon, Fu-Shi Quan   +8 more
doaj   +1 more source

Motility-sorting of self-propelled particles in micro-channels [PDF]

EPL, 107 (2014) 36003, 2014
Spontaneous segregation of run-and-tumble particles with different velocities in microchannels is investigated by numerical simulations. Self-propelled particles are known to accumulate in the proximity of walls. Here we show how fast particles expel slower ones from the wall leading to a segregated state.
arxiv   +1 more source

Serodiagnosis of Primary Infections with Human Parvovirus 4, Finland [PDF]

, 2011
To determine the prevalence of parvovirus 4 infection and its clinical and sociodemographic correlations in Finland, we used virus-like particle–based serodiagnostic procedures (immunoglobulin [Ig] G, IgM, and IgG avidity) and PCR.
Anne Lahtinen, Anu Kantele, Arun Kumar, Colin Sharp, Enders, Eric Delwart, Fryer, Hedman, Jones, Kantola, Kirsi Liitsola, Kivelä, Kivelä, Klaus Hedman, Lea Hedman, Longhi, Lurcharchaiwong, Maija Lappalainen, Manning, Maria Söderlund-Venermo, Matti Ristola, Panning, Peter Simmonds, Pia Kivelä, Sharp, Simmonds, Söderlund-Venermo, Tuke   +27 more
core   +2 more sources

Virus-Like Particles in Cephalosporium acremonium [PDF]

Applied Microbiology, 1971
Cephalosporium acremonium cultures were studied for the presence of virus-like particles. Relatively few particles were found in the preparations, indicating that the number of particles present in these cells may be much lower than in Penicillium species.
L. F. Ellis, L. E. Day
openaire   +3 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

A novel polyethyleneimine-coated adeno-associated virus-like particle formulation for efficient siRNA delivery in breast cancer therapy: preparation and in vitro analysis

International Journal of Nanomedicine, 2012
Wei Shao1, Arghya Paul1, Sana Abbasi1, Parminder S Chahal2, Jimmy A Mena2, Johnny Montes2, Amine Kamen2, Satya Prakash11Biomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering and Artificial Cells and Organs ...
Shao W, Paul A, Abbasi S, Chahal PS, Mena JA, Montes J, Kamen A, Prakash S   +7 more
doaj  

Next generation designer virus-like particle vaccines for dengue

Expert Review of Vaccines, 2019
Introduction: A safe and efficacious vaccine for dengue continues to be an unmet public health need. The recent licensing of a dengue vaccine (Dengvaxia) developed by Sanofi has brought to the fore the safety issue of vaccine-induced infection ...
Rahul Shukla, Viswanathan Ramasamy, Ravi Kant Rajpoot, Upasana Arora, Ankur Poddar, Richa Ahuja, Hemalatha Beesetti, Sathyamangalam Swaminathan, Navin Khanna   +8 more
doaj   +1 more source

Design Concepts of Virus-Like Particle-Based HIV-1 Vaccines

Frontiers in Immunology, 2020
Prophylactic vaccines remain the best approach for controlling the human immunodeficiency virus-1 (HIV-1) transmission. Despite the limited efficacy of the RV144 trial in Thailand, there is still no vaccine candidate that has been proven successful ...
Chun-Wei Chen, Narcís Saubi, Narcís Saubi, Joan Joseph-Munné, Joan Joseph-Munné, Joan Joseph-Munné   +5 more
doaj   +1 more source

Simulation of deterministic energy-balance particle agglomeration in turbulent liquid-solid flows [PDF]

, 2017
An efficient technique to simulate turbulent particle-laden flow at high mass loadings within the four-way coupled simulation regime is presented. The technique implements large eddy simulation, discrete phase simulation, a deterministic treatment of inter-particle collisions and an energy-balanced particle agglomeration model.
arxiv   +1 more source