Results 191 to 200 of about 203,768 (257)

Bivalent virus-like particles expressing SPECT1 and CSP trigger pre-erythrocytic malaria immunity and protect against transgenic <i>Plasmodium falciparum</i> sporozoite challenge in mice. [PDF]

Front Immunol
Turan G, Mukhopadhyay E, Truby A, Fedorova K, Peralta Alvarez MP, Alharbi NK, Hill AVS, Salman AM.   +7 more
europepmc   +1 more source

ZDHHC17‐Mediated CDK4 Palmitoylation Drives Cell Cycle Progression and Orchestrates Cancer Immune Surveillance

Advanced Science, EarlyView.
ZDHHC17 palmitoylates CDK4, which together with TRAF6‐mediated ubiquitination, drives cell cycle progression and immune surveillance, revealing a rational combination of CDK4 inhibitors with immune checkpoint blockers for ZDHHC17‐driven cancers. ABSTRACT Uncontrolled cell cycle progression is a hallmark of cancer, tightly regulated by both intrinsic ...
Zekang Wang, Peipei Song, Xueji Wu, Lei Wang, Wei Xie, Pinning Feng, Chao Cheng, Jianping Guo   +7 more
wiley   +1 more source

In vitro characterization of cellular responses elicited by endosomal TLR agonists encapsulated in Qβ virus-like particles. [PDF]

BMC Immunol
Hasibuzzaman MM, Ibarra B, Khan IN, Meagher TC, Lemke-Miltner CD, Weiner GJ, Simons AL.   +6 more
europepmc   +1 more source

SIRT6‐Mediated Deacetylation of ATF3 Promotes Silica‐Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α

Advanced Science, EarlyView.
SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng, Wenxia Bu, Fengxu Wang, Yueyuan Jin, Rongzhu Liu, Rui Zhao, Xuehai Wang, Mengna Jiang, Jinping Shen, Xinhang Cheng, Zuming Chen, Li Zhu, Jinlong Li, Zhenzhong Ge, Shichen Miao, Haotian Xu, Xiaoyu Zhou, Dongming Wang, Xinyuan Zhao   +18 more
wiley   +1 more source

Customised virus-like particles: Opening a new chapter for clinical precision gene therapy. [PDF]

Clin Transl Med
Zhu X, Zhang Q, Zhou X, Cai Y, Hong J.
europepmc   +1 more source

NAT10‐Mediated ac4C Modification of circANKRD12 Reprograms the Tumor Microenvironment

Advanced Science, EarlyView.
NAT10‐dependent acetylation of circANKRD12 drives translation of the circANKRD12_354aa protein, which binds HDAC2 to stabilize c‐Myc via deubiquitination, promoting multiple myeloma (MM) cell proliferation. Concurrently, the circANKRD12‐HDAC2 axis suppresses H3ac‐mediated transcription of IFN‐γ, TNF‐α, and GZMB in NK cells, leading to NK cell ...
Jiale Zhang, Hui Shi, Chen Wang, Zihao Liu, Lianxin Zhou, Xinyu Lv, Mengjie Guo, Ye Yang, Chunyan Gu   +8 more
wiley   +1 more source

Modular Virus-like Particles for Antigen Presentation: Comparing Genetic Fusion and Click-Chemistry for Purification. [PDF]

Int J Mol Sci
Balbierer K, Jenzelewski V, Herrmann FC, Piontek M, Jose J.   +4 more
europepmc   +1 more source

Muscle-specific gene editing therapy via mammalian fusogen-directed virus-like particles. [PDF]

Nat Commun
Zhou SK, Luo JT, Chen YF, Lu ZD, Jian QH, Jiang SQ, Li J, Zhang XQ, Tan XY, Yang XZ, Xu CF, Wang J.   +11 more
europepmc   +1 more source

Stabilization of norovirus GII.3 virus-like particles by rational disulfide engineering. [PDF]

NPJ Vaccines
Warren C, Galli JD, Bystol K, O'Donnell G, Swartz AR, Dewar EA, Fulton CM, Shen P, Gonzalez-Fernandez E, DeWitt LA, Jeong U, Pan OC, Miller S, Fridman A, David C, Chen Z, Wei J.   +16 more
europepmc   +1 more source