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Enzyme Stabilization by Virus-Like Particles

Biochemistry, 2020
The properties of enzymes packaged within the coat protein shell of virus-like particles (VLPs) were studied to provide a comprehensive assessment of such factors. Such entrainment did not seem to perturb enzyme function, but it did significantly enhance enzyme stability against several denaturing stimuli such as heat, organic solvents, and chaotropic ...
Soumen Das   +3 more
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Structures of virus and virus-like particles

Current Opinion in Structural Biology, 2000
Virus structures continue to be the basis for mechanistic virology and serve as a paradigm for solutions to problems concerning macromolecular assembly and function in general. The use of X-ray crystallography, electron cryomicroscopy and computational and biochemical methods has provided not only details of the structural folds of individual viral ...
J E, Johnson, W, Chiu
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Virus-Like Particles of Yeast

Annual Review of Microbiology, 1980
INTRODUCTION ......... .. ..... ..... ..... .. ... ....... 49 The Killer Character 50 The killing reaction ....... ..... 51 Other killer systems .. ......... ......... ..... ...... ...... 51 ScVas a model system 52 PHYSICAL PROPERTIES OF ScV PARTICLES 52 CAPSID POLYPEPTIDES ........ 55 ScV RNAs 56 Structure .. .
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Virus-like particles in human milk

Cancer, 1971
Human milk from 59 women was studied by electron microscopy for the presence of viruslike particles. 2 types of viruslike particles were seen: 1) a small particle 20-40 mM and 2) a larger particle closely resembling the murine oncogenic ribonucleic acid virus.
W F, Feller, H C, Chopra
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Hybrid Ty Virus-Like Particles

International Reviews of Immunology, 1994
Vaccines need to activate antigen presenting cells, overcome genetic restriction in T-cell responses and elicit both T and B memory cells. In order to produce recombinant vaccines which can do this, considerable effort has been put into developing particulate antigen presentation systems to generate polyvalent, high molecular weight antigens which ...
S E, Adams   +3 more
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Meningoencephalitis with toroidal virus-like particles

Acta Neuropathologica, 1975
A previously healthy middle aged man died following a 6 month illness which presented with middle ear symptoms, apparently resolved, and then 2 months later manifested as encephalitis. The illness was characterized initially by depression and intellectual deterioration. No family member or working associate was affected. The clinical diagnosis of viral
H C, Powell, A I, Braude, P W, Lampert
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Virus-like particles in Basidiobolus species

Mycopathologia, 1986
Transmission electron microscopy of ultrathin sections of hyphal cells of Basidiobolus haptosporus and B. ranarum revealed the presence of particulate inclusions consistent in morphology with that described in certain other fungi as virus-like particles.
R G, Garrison, A M, Fiskin
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A VIRUS‐LIKE PARTICLE ASSOCIATED WITH PSORIASIS

Acta Pathologica Microbiologica Scandinavica Series B: Microbiology, 1983
Virus‐like particles were demonstrated by electron microscopy of specimens from psoriatic plaques. Cell cultures established from plaques released particles, showing the morphological features of a retrovirus, for a prolonged period. The particles had a buoyant density of 1.17 g/cc and contained a surface protein of Mr 70,000 which bound to ...
A B, Dalen   +3 more
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Virus-Like Particles as Particulate Vaccines

Current HIV Research, 2010
Particulate structures hold great promise for the development of effective and affordable recombinant prophylactic as well as therapeutic vaccines. Different types of particulate structures, including virus-like particles (VLPs) and virosomes, have been developed depending on the nature of the viral pathogen to be targeted and the type of immune ...
Luigi, Buonaguro   +2 more
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Virus-like particles in a human ameloblastoma

Archives of Oral Biology, 1970
Abstract An electron microscopic study of an ameloblastoma revealed in the nuclei, cytoplasm and microvilli of some neoplastic cells the presence of helices of 150 A to 180 A periodicity, with a diameter of 200 A to 220 A. These helices appeared to consist of filaments measuring about 90A in diameter.
A, Csiba   +3 more
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