Results 51 to 60 of about 615,631 (266)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Anti-zika virus activity of polyoxometalates [PDF]

Antiviral Research, 2019
Zika virus (ZIKV) is an emerging infectious viral pathogen associated with severe fetal cerebral anomalies and the paralytic Guillain-Barrè syndrome in adults. It was the cause of a recent global health crisis following its entrance into a naïve population in the Americas. Nowadays, no vaccine or specific antiviral against ZIKV is available.
Rachele Francese, Andrea Civra, Massimo Rittà, Manuela Donalisio, Monica Argenziano, Roberta Cavalli, Ali S. Mougharbel, Ulrich Kortz, David Lembo   +8 more
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Alphavirus-induced hyperactivation of PI3K/AKT directs pro-viral metabolic changes.

PLoS Pathogens, 2018
Virus reprogramming of cellular metabolism is recognised as a critical determinant for viral growth. While most viruses appear to activate central energy metabolism, different viruses have been shown to rely on alternative mechanisms of metabolic ...
Michela Mazzon, Cecilia Castro, Bastian Thaa, Lifeng Liu, Margit Mutso, Xiang Liu, Suresh Mahalingam, Julian L Griffin, Mark Marsh, Gerald M McInerney   +9 more
doaj   +1 more source

Phosphodiesterase 4 inhibitors attenuate virus‐induced activation of eosinophils from asthmatics without affecting virus binding

Pharmacology Research & Perspectives, 2020
Acute respiratory virus infections, such as influenza and RSV, are predominant causes of asthma exacerbations. Eosinophils act as a double‐edged sword in exacerbations in that they are activated by viral infections but also can capture and inactivate ...
Yanaika Shari Sabogal Piñeros, Tamara Dekker, Barbara Smids, Christof J. Majoor, Lara Ravanetti, Gino Villetti, Maurizio Civelli, Fabrizio Facchinetti, René Lutter   +8 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Cytolytic Virus Activation Therapy for Epstein-Barr Virus–Driven Tumors [PDF]

Clinical Cancer Research, 2012
Abstract Purpose: Nasopharyngeal carcinoma (NPC) is causally linked to Epstein–Barr virus (EBV) infection. Because all tumor cells carry EBV, the virus itself is a potential target for therapy. In these tumor cells, EBV hides in a latent state and expresses only a few non-immunogenic proteins for EBV maintenance and contributes to ...
Wildeman, M.A., Novalic, Z., Verkuijlen, S.A.W.M., Juwana, H., Huitema, A.D.R., Tan, I.B., Middeldorp, J.M., de Boer, J.P., Greijer, A.E.   +8 more
openaire   +2 more sources

Anti-Herpes Virus Activity Of Lactobacillus’ Postbiotics

BioMedicine, 2022
Background: Recently, various lactic acid bacteria (LAB) and their post-metabolites, have shown many positive effects on human and animal welfare. They appear to be beneficial in different disorders and pathological conditions, including in a broad-spectrum of infectious diseases.
Vilhelmova-Ilieva, Neli, Atanasov, Georgi, Simeonova, Lora, Dobreva, Lili, Mancheva, Kapka, Trepechova, Madlena, Danova, Svetla   +6 more
openaire   +3 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Rotavirus activates lymphocytes from non-obese diabetic mice by triggering toll-like receptor 7 signaling and interferon production in plasmacytoid dendritic cells.

PLoS Pathogens, 2014
It has been proposed that rotavirus infection promotes the progression of genetically-predisposed children to type 1 diabetes, a chronic autoimmune disease marked by infiltration of activated lymphocytes into pancreatic islets.
Jessica A Pane, Nicole L Webster, Barbara S Coulson   +2 more
doaj   +1 more source