Results 51 to 60 of about 960,253 (307)

The regions of the herpes simplex virus type 1 immediate early protein Vmwl75 required for site specific DNA binding closely correspond to those involved in transcriptional regulation [PDF]

, 1988
The immediate-early (IE) protein Vmw175 (ICP4) of HSV-1 is required for the transcription of later classes of viral genes and the repression of IE gene expression.
Everett, R.D., Paterson, T.
core   +1 more source

Activation of TLR4 by viral glycoproteins: A double-edged sword?

Frontiers in Microbiology, 2022
Recognition of viral infection by pattern recognition receptors is paramount for a successful immune response to viral infection. However, an unbalanced proinflammatory response can be detrimental to the host.
Emily A. Halajian, Emmanuelle V. LeBlanc, Katrina Gee, Che C. Colpitts   +3 more
doaj   +1 more source

Modulation of Host Immunity by Human Respiratory Syncytial Virus Virulence Factors: A Synergic Inhibition of Both Innate and Adaptive Immunity [PDF]

, 2017
Indexación: Web of Science; Scopus.The Human Respiratory Syncytial Virus (hRSV) is a major cause of acute lower respiratory tract infections (ARTIs) and high rates of hospitalizations in children and in the elderly worldwide.
Alexis M. Kalergis, Alexis M. Kalergis, Claudia A. Riedel, Emma Rey-Jurado, Gisela Canedo-Marroquín, Juan M. Saavedra, Margarita K. Lay, Margarita K. Lay, Orlando Acevedo-Acevedo, Susan M. Bueno   +9 more
core   +2 more sources

Map3k14 as a Regulator of Innate and Adaptive Immune Response during Acute Viral Infection

Pathogens, 2020
The replication of virus in secondary lymphoid organs is crucial for the activation of antigen-presenting cells. Balanced viral replication ensures the sufficient availability of antigens and production of cytokines, and both of which are needed for ...
Thamer A. Hamdan, Hilal Bhat, Lamin B. Cham, Tom Adomati, Judith Lang, Fanghui Li, Ali Murtaza, Cornelia Hardt, Philipp A. Lang, Vikas Duhan, Karl S. Lang   +10 more
doaj   +1 more source

Endosymbiotic RNA virus inhibits Leishmania-induced caspase-11 activation

iScience, 2021
Summary: New World species of the intracellular protozoan parasites of the Leishmania genus can cause mucocutaneous leishmaniases. The presence of an endosymbiotic Leishmania RNA virus (LRV) in Leishmania guyanensis (L.g.) promotes disease exacerbation ...
Renan V.H. de Carvalho, Djalma S. Lima-Júnior, Caroline V. de Oliveira, Dario S. Zamboni   +3 more
doaj   +1 more source

Viral factors in influenza pandemic risk assessment [PDF]

, 2016
The threat of an influenza A virus pandemic stems from continual virus spillovers from reservoir species, a tiny fraction of which spark sustained transmission in humans.
Barclay, Wendy, Beauchemin, Catherine A.A., Bedford, Trevor, Belser, Jessica A., Cobey, Sarah, Friedrich, Thomas C., Handel, Andreas, Herfst, Sander, Kasson, Peter M., Lipsitch, Marc, Lloyd-Smith, James O., Maurer-Stroh, Sebastian, Murcia, Pablo R., Raman, Rahul, Riley, Steven, Roche, Benjamin, Russell, Charles J., Russell, Colin A., Wilke, Claus O.   +18 more
core   +4 more sources

The formin FHOD1 and the small GTPase Rac1 promote vaccinia virus actin-based motility [PDF]

, 2013
Vaccinia virus dissemination relies on the N-WASP– ARP2/3 pathway, which mediates actin tail formation underneath cell-associated extracellular viruses (CEVs).
Alberts, Alvarez, Arakawa, Bagrodia, Bernardini, Block, Boujemaa-Paterski, Chong, Chong, Diego E. Alvarez, Earl, Engelstad, Feig, Frischknecht, Fukuoka, Gasteier, Goldberg, Haglund, Hannemann, Harris, Harris, Heindl, Hervé Agaisse, Hiller, Hollinshead, Hoppe, Humphries, Isaacs, Katz, Kleba, Koka, Kovar, Krall, Lammers, Lasa, Li, Madrid, Moseley, Moseley, Newsome, Newsome, Nezami, Otomo, Parkinson, Pollard, Pring, Pruyne, Qiu, Ridley, Rietdorf, Roberts, Rolls, Romero, Röttger, Sanderson, Scaplehorn, Schmelz, Schulte, Schönichen, Schönichen, Serio, Shibata, Siripala, Skoble, Smith, Suzuki, Takeya, Tooze, van Eijl, van Eijl, Wallar, Ward, Ward, Watanabe, Weisswange, Welch, Westendorf, Westendorf, Wolffe, Wolffe   +79 more
core   +2 more sources

Apoptotic epitope-specific CD8+ T cells and interferon signaling intersect in chronic hepatitis C virus infection [PDF]

, 2015
CD8(+) T cells specific to caspase-cleaved antigens derived from apoptotic T cells represent a principal player in chronic immune activation (CIA). Here, we found that both apoptotic epitope (AE)-specific and hepatitis C virus (HCV)-specific CD8(+) T ...
Accapezzato, Daniele, Barnaba, Vincenzo, Calvo, Ludovica, Cavallari, EUGENIO NELSON, Citro, Alessandra, Coccia, Eliana M, D'Ettorre, Gabriella, DE MARZIO, Paolo, DI FILIPPO, Simona, Grazi, Gian Luca, Labbadia, Giancarlo, Martini, Helene, Martire, Carmela, Piconese, Silvia, Rizzo, Fabiana, Sette, Alessandro, Severa, Martina, Sidney, John, Vullo, Vincenzo   +18 more
core   +1 more source

Virus-based vaccine vectors with distinct replication mechanisms differentially infect and activate dendritic cells

npj Vaccines, 2021
The precise mechanism by which many virus-based vectors activate immune responses remains unknown. Dendritic cells (DCs) play key roles in priming T cell responses and controlling virus replication, but their functions in generating protective immunity ...
Carolina Chiale, Anthony M. Marchese, Yoichi Furuya, Michael D. Robek   +3 more
doaj   +1 more source

Two-year follow-up of macaques developing intermittent control of the human immunodeficiency virus homolog simian immunodeficiency virus SIVmac251 in the chronic phase of infection [PDF]

, 2015
Off-therapy control of viremia by HIV-infected individuals has been associated with two likely players: a restricted viral reservoir and an efficient cell-mediated immune response.
Arts, Eric, Biffoni, Mauro, Chung, Hye Kyung, Farrell, Nicholas, Labranche, Celia, Lewis, Mark G., Montefiori, David, Nickel, Gabrielle, Pal, Ranajit, PALAMARA, ANNA TERESA, Robert Guroff, Marjorie, Sacha, Jonah B., Savarino, Andrea, Shytaj, Iart Luca, Vargas Inchaustegui, Diego   +14 more
core   +2 more sources