Influenza Virus-Induced Oxidized DNA Activates Inflammasomes
iScience, 2020 Summary: Influenza virus M2 and PB1-F2 proteins have been proposed to activate the Nod-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome in macrophages by altering intracellular ionic balance or mitochondrial reactive oxygen species ...
Miyu Moriyama +5 more
doaj +1 more source
The actin nucleator Spir-1 is a virus restriction factor that promotes innate immune signalling.
PLoS Pathogens, 2022 Cellular proteins often have multiple and diverse functions. This is illustrated with protein Spir-1 that is an actin nucleator, but, as shown here, also functions to enhance innate immune signalling downstream of RNA sensing by RIG-I/MDA-5. In human and
Alice A Torres +6 more
doaj +1 more source
Activation of the interferon induction cascade by influenza A viruses requires viral RNA synthesis and nuclear export [PDF]
, 2014 This work is supported by grants from the Wellcome Trust (grants 087751/A/08/Z) and MRC (G1001726/1).We have examined the requirements for virus transcription and replication and thus the roles of input and progeny genomes in the generation of interferon
Randall, Richard E +3 more
core +1 more source
Deep sequencing analysis of defective genomes of parainfluenza virus 5 and their role in interferon induction [PDF]
, 2013 This work was supported by The Wellcome Trust (087751/A/08/Z).Preparations of parainfluenza virus 5 (PIV5) that are potent activators of the interferon (IFN) induction cascade were generated by high-multiplicity passage in order to accumulate defective ...
Killip, M. J. +13 more
core +1 more source
Resting regulatory CD4 T cells: a site of HIV persistence in patients on long-term effective antiretroviral therapy. [PDF]
PLoS ONE, 2008 BACKGROUND: In HIV-infected patients on long-term HAART, virus persistence in resting long-lived CD4 T cells is a major barrier to curing the infection.
Tu-Anh Tran +11 more
doaj +1 more source
Activation of One Plant Virus by Another
Nature, 1960 TOBACCO necrosis is a disease that can be caused by several serologically unrelated viruses1, all of which are soil-borne and cause necrotic local lesions in leaves of tobacco (Nicotiana tabacum L.) and French bean (Phaseolus vulgaris L.) plants. The virus Bawden and Pirie2,3 called the ‘Rothamsted culture’ differed in several respects from other ...
Kassanis, B., Nixon, H. L.
openaire +2 more sources
Epstein-Barr Virus LF2: an Antagonist to Type 1 Interferon [PDF]
, 2009 Upon viral infection, the major defense mounted by the host immune system is activation of the interferon (IFN)-mediated antiviral pathway, which is mediated by IFN regulatory factors (IRFs).
Shin, Young Chul +8 more
core +1 more source
Inter-domain communication in SARS-CoV-2 spike proteins controls protease-triggered cell entry
Cell Reports, 2022 Summary: SARS-CoV-2 continues to evolve into variants of concern (VOC), with greatest variability in the multidomain, entry-facilitating spike proteins. To recognize the significance of adaptive spike protein changes, we compare variant SARS-CoV-2 virus ...
Enya Qing +7 more
doaj +1 more source
Flavonoids as Molecules With Anti-Zika virus Activity [PDF]
Frontiers in Microbiology, 2021 Zika virus (ZIKV) is an arthropod-born virus that is mainly transmitted to humans by mosquitoes of the genus Aedes spp. Since its first isolation in 1947, only a few human cases had been described until large outbreaks occurred on Yap Island (2007), French Polynesia (2013), and Brazil (2015).
Depieri Cataneo, Allan Henrique +10 more
openaire +4 more sources
Interferon, virus vaccines and antiviral drugs [PDF]
, 2008 The emergence of viruses with zoonotic potential, i.e. with the potential ability to cross species barriers to infect unnatural hosts, poses a huge threat to humans.
Rodrigues, Ana Mara Lopes
core +2 more sources