Ebola virus VP35 induces high-level production of recombinant TPL-2–ABIN-2–NF-κB1 p105 complex in co-transfected HEK-293 cells [PDF]
, 2013 Activation of PKR (double-stranded-RNA-dependent protein kinase) by DNA plasmids decreases translation, and limits the amount of recombinant protein produced by transiently transfected HEK (human embryonic kidney)-293 cells.
Apostolaki +47 more
core +1 more source
Autophagic machinery activated by dengue virus enhances virus replication
Virology, 2008 Autophagy is a cellular response against stresses which include the infection of viruses and bacteria. We unravel that Dengue virus-2 (DV2) can trigger autophagic process in various infected cell lines demonstrated by GFP-LC3 dot formation and increased LC3-II formation.
Lee, Ying-Ray +9 more
openaire +2 more sources
Chronic Active Epstein–Barr Virus Disease [PDF]
Frontiers in Immunology, 2017 Chronic active Epstein-Barr virus (CAEBV) disease is a rare disorder in which persons are unable to control infection with the virus. The disease is progressive with markedly elevated levels of EBV DNA in the blood and infiltration of organs by EBV-positive lymphocytes. Patients often present with fever, lymphadenopathy, splenomegaly, EBV hepatitis, or
Hiroshi Kimura, Jeffrey I. Cohen
openaire +3 more sources
Cell Reports, 2016 Host response to RNA virus infection is sensed by RNA sensors such as RIG-I, which induces MAVS-mediated NF-κB and IRF3 activation to promote inflammatory and antiviral responses, respectively.
Changying Jiang +10 more
doaj +1 more source
Resting regulatory CD4 T cells: a site of HIV persistence in patients on long-term effective antiretroviral therapy. [PDF]
PLoS ONE, 2008 BACKGROUND: In HIV-infected patients on long-term HAART, virus persistence in resting long-lived CD4 T cells is a major barrier to curing the infection.
Tu-Anh Tran +11 more
doaj +1 more source
Inter-domain communication in SARS-CoV-2 spike proteins controls protease-triggered cell entry
Cell Reports, 2022 Summary: SARS-CoV-2 continues to evolve into variants of concern (VOC), with greatest variability in the multidomain, entry-facilitating spike proteins. To recognize the significance of adaptive spike protein changes, we compare variant SARS-CoV-2 virus ...
Enya Qing +7 more
doaj +1 more source
Protease inhibitors targeting coronavirus and filovirus entry. [PDF]
, 2015 In order to gain entry into cells, diverse viruses, including Ebola virus, SARS-coronavirus and the emerging MERS-coronavirus, depend on activation of their envelope glycoproteins by host cell proteases.
Agudelo, Juliet +10 more
core +1 more source
Generation of virus-specific cytotoxic T cells in vitro II. Induction requirements with functionally inactivated virus preparations [PDF]
, 1980 Using noninfectious Sendai virus preparations after selective enzymatic digestion of either of the two viral envelope glycoproteins, it was possible to study the effect of different virion-cell membrane interactions on virus-specific cytotoxic T ...
Bosslet +27 more
core +1 more source
Anti-RNA virus activity of polyoxometalates
Biomedicine & Pharmacotherapy, 2006 The anti-RNA virus activity of polyoxometalates (POM) is reviewed, with a special emphasis on the anti-respiratory virus activities. There are many causative agents of acute viral respiratory infections; and it is rather difficult to identify the relevant agent in a given case by rapid clinical means.
Shiroh Shigeta +4 more
openaire +2 more sources
Interferon-beta pretreatment of conventional and plasmacytoid human dendritic cells enhances their activation by influenza virus. [PDF]
PLoS Pathogens, 2008 Influenza virus produces a protein, NS1, that inhibits infected cells from releasing type I interferon (IFN) and blocks maturation of conventional dendritic cells (DCs).
Hannah Phipps-Yonas +4 more
doaj +1 more source