Results 41 to 50 of about 615,631 (266)
Human Pegivirus Type 1: A Common Human Virus That Is Beneficial in Immune-Mediated Disease?
Frontiers in Immunology, 2022 Two groups identified a novel human flavivirus in the mid-1990s. One group named the virus hepatitis G virus (HGV) and the other named it GB Virus type C (GBV-C).
Jack T. Stapleton, Jack T. Stapleton
doaj +1 more source
Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review
Pediatric Blood &Cancer, EarlyView.ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean +7 more
wiley +1 more source
Amino acid substitutions at the HIV-1 transframe region significantly impair virus infectivity.
PLoS ONE, 2022 A transframe region within HIV-1 Gag-Pol (referred to as p6* or p6pol), directly linked to the protease (PR) N-terminus, plays a pivotal role in modulating PR activation. To identify specific p6* residues involved in PR activation, we created a series of
Fu-Hsien Yu +2 more
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Specificity of a Neuraminidase Activity of Sendai Virus
Experimental Biology and Medicine, 1967 SummaryThe pH optima for the neuraminidase activity of several myxoviruses were determined. The same pH optimum was found for Sendai virus grown in either egg or L cell and for NDV which is closely related to the former virus. However, the antibody prepared against the neuraminidase fraction of egg-grown Sendai virus showed an inhibitory effect only on
H, Tozawa, M, Homma, N, Ishida
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Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
The Chikungunya Virus nsP3 Macro Domain Inhibits Activation of the NF-κB Pathway
VirusesThe role of the chikungunya virus (CHIKV) non-structural protein 3 (nsP3) in the virus lifecycle is poorly understood. The protein comprises three domains.
Grace C. Roberts +2 more
doaj +1 more source
Anti-RNA virus activity of polyoxometalates
Biomedicine & Pharmacotherapy, 2006 The anti-RNA virus activity of polyoxometalates (POM) is reviewed, with a special emphasis on the anti-respiratory virus activities. There are many causative agents of acute viral respiratory infections; and it is rather difficult to identify the relevant agent in a given case by rapid clinical means.
Shiroh Shigeta +4 more
openaire +2 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
PLoS ONE, 2013 Influenza continues to pose a threat to humans by causing significant morbidity and mortality. Thus, it is imperative to investigate mechanisms by which influenza virus manipulates the function of host factors and cellular signal pathways. In this study,
Young-Jin Seo +6 more
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mBio, 2016 Virus binding to the cell surface triggers an array of host responses, including activation of specific signaling pathways that facilitate steps in virus entry.
Samantha D. O’Hara, Robert L. Garcea
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