Results 21 to 30 of about 646,497 (314)

Porcine Trypsin in the Manufacture of Biological Medicinal Products. Risks and Safety Requirements

Биопрепараты: Профилактика, диагностика, лечение, 2018
Trypsin is a reagent widely used in the manufacture of biological medicinal products (BMPs). Until recently, pancreata of cattle, pigs and poultry were the main sources of trypsin preparations. The discovery of the disease called «transmissive spongiform
S. M. Sukhanov, E. M. Petruchuk
doaj   +1 more source

A fatal case of hepatitis B virus (HBV) reactivation during long-term, very-low-dose steroid treatment in an inactive HBV carrier [PDF]

Clinical and Molecular Hepatology, 2012
Hepatitis B virus (HBV) may be reactivated after chemotherapy or immunosuppressive therapy, and therefore administration of antiviral agents before such treatment is recommended.
Joong Ho Bae, Joo Hyun Sohn, Hye Soon Lee, Hye Sun Park, Yil Sik Hyun, Tae Yeob Kim, Chang Soo Eun, Yong Cheol Jeon, Dong Soo Han   +8 more
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The Haemagglutinating Activity of Berne Virus

Journal of General Virology, 1986
Berne virus possesses haemagglutinating activity which is inhibited by antisera that neutralize the infectivity of the virus. In decreasing order, human, rabbit and guinea-pig erythrocytes were agglutinated whereas agglutination was not observed with rat, goose, chicken or horse red blood cells. This pattern is different from that seen with the closely
R, Zanoni, M, Weiss, E, Peterhans
openaire   +2 more sources

Trypsin. Properties and Use in the Production of Biological Medicinal Products

Биопрепараты: Профилактика, диагностика, лечение, 2018
The production of biological medicinal products used for prophylactic, diagnostic and therapeutic purposes includes the use of inherently  variable biological processes and materials.
S. M. Sukhanova, E. M. Petruchuk, A. A. Generalov   +2 more
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Activation thermodynamics of virus adsorption to solids [PDF]

Applied and Environmental Microbiology, 1988
The kinetics of bacteriophage MS2, T2, and f2 adsorption to powdered nitrocellulose and disrupted Seitz S1 filters at pH 7 were determined as a function of temperature. Data from these studies were combined with data produced in a previous study on MS2 adsorption to clay by Stagg et al. (Appl. Environ. Microbiol. 33:385-391, 1977).
D R, Preston, S R, Farrah
openaire   +2 more sources

Blocking TLR7- and TLR9-mediated IFN-α Production by Plasmacytoid Dendritic Cells Does Not Diminish Immune Activation in Early SIV Infection [PDF]

, 2013
Persistent production of type I interferon (IFN) by activated plasmacytoid dendritic cells (pDC) is a leading model to explain chronic immune activation in human immunodeficiency virus (HIV) infection but direct evidence for this is lacking.
Simon C Watkins, Normolle, D, Kader, M, Elizabeth R Wonderlich, Guiducci, C, Smith, Amanda P., Watkins, SC, Amanda P. Smith (437248), Normolle, Daniel, Watkins Simon C., Franck J. Barrat (437251), Smith Amanda P., Simon M Barratt-Boyes, Daniel Normolle, Daniel Normolle (437250), Barrat Franck J., Simon M. Barratt-Boyes (264203), Normolle Daniel, Wonderlich Elizabeth R., Franck J Barrat, Barratt-Boyes Simon M., Guiducci, Cristiana, Barrat, Franck J., Kader, Muhamuda, Guiducci Cristiana, Wonderlich, ER, Cristiana Guiducci, Barrat, FJ, Watkins, Simon C., Amanda P Smith, Barratt-Boyes, SM, Muhamuda Kader, Smith, AP, Wonderlich, Elizabeth R., Cristiana Guiducci (437249), Simon C. Watkins (39900), Barratt-Boyes, Simon M., Muhamuda Kader (437247), Elizabeth R. Wonderlich (270792), Kader Muhamuda   +39 more
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An investigation of herpes simplex virus promoter activity compatible with latency establishment reveals VP16-independent activation of immediate-early promoters in sensory neurones [PDF]

, 2011
Herpes simplex virus (HSV) type-1 establishes lifelong latency in sensory neurones and it is widely assumed that latency is the consequence of a failure to initiate virus immediate-early (IE) gene expression. However, using a Ore reporter mouse system in
Heather M. Coleman, Connor, V., Proenca, J.T., Michael P. Nicoll, Nicoll, M.P., Jane Arthur, Arthur, J., Preston, C.M., João T. Proença, Christopher M. Preston, Coleman, H.M., Efstathiou, S., Stacey Efstathiou, Viv Connor   +13 more
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Influenza Virus-Induced Oxidized DNA Activates Inflammasomes

iScience, 2020
Summary: Influenza virus M2 and PB1-F2 proteins have been proposed to activate the Nod-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome in macrophages by altering intracellular ionic balance or mitochondrial reactive oxygen species ...
Miyu Moriyama, Minami Nagai, Yuhei Maruzuru, Takumi Koshiba, Yasushi Kawaguchi, Takeshi Ichinohe   +5 more
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The actin nucleator Spir-1 is a virus restriction factor that promotes innate immune signalling.

PLoS Pathogens, 2022
Cellular proteins often have multiple and diverse functions. This is illustrated with protein Spir-1 that is an actin nucleator, but, as shown here, also functions to enhance innate immune signalling downstream of RNA sensing by RIG-I/MDA-5. In human and
Alice A Torres, Stephanie L Macilwee, Amir Rashid, Sarah E Cox, Jonas D Albarnaz, Claudio A Bonjardim, Geoffrey L Smith   +6 more
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CARMA3 Is a Host Factor Regulating the Balance of Inflammatory and Antiviral Responses against Viral Infection

Cell Reports, 2016
Host response to RNA virus infection is sensed by RNA sensors such as RIG-I, which induces MAVS-mediated NF-κB and IRF3 activation to promote inflammatory and antiviral responses, respectively.
Changying Jiang, Zhicheng Zhou, Yanping Quan, Shilei Zhang, Tingting Wang, Xueqiang Zhao, Clayton Morrison, Mark T. Heise, Wenqian He, Matthew S. Miller, Xin Lin   +10 more
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